DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and lgr4

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001340791.1	Gene:	lgr4 / 558825	ZFINID:	ZDB-GENE-111013-1	Length:	971	Species:	Danio rerio

Alignment Length:	826	Identity:	200/826 - (24%)
Similarity:	337/826 - (40%)	Gaps:	207/826 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NLTAVSLAQSTDTPLTATMPRSAWKCCCWNAS---------NQAEEVECRCEGDGLNRVPQTLTL 130
            ||.|::||.:..|.:    |.:|:.    |.|         |:.:|:...| .:||:.: :||.|
Zfish   181 NLQALTLALNRITHI----PDNAFA----NLSSLVVLHLHNNRIQEIGKNC-FNGLDNL-ETLDL 235

  Fly   131 PIQRLTI---ASAGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPK 192
            ....|.|   |...||:|:..|   :.|.          .:..|.:|||...:|||||::.:.|
Zfish   236 NFNNLKIFPEAIQMLPKLKELG---FHSN----------NIASIPEGAFCRNSLLRTIHLFDNP- 286

  Fly   193 LTFLSKDVFLGISD--------------------TVDI--IRIINSGLTRVP-----DLGHLPPH 230
            |:|:....|..:||                    |:::  :.:..:.:..:|     ||
Zfish   287 LSFVGTTAFQNLSDLHSLMLRGASMMQDFPSLTGTINLESLTLTGTKIRSIPADLCEDL------ 345

  Fly   231 NILQMIDLDNNQITRIDSKSIKVKTAQLILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHP 294
            .:|:.:||..|.|..:.|....|:...:.|.:|:|..:|...|.| :.:..|.|..| :::.:|.
Zfish   346 TVLRTVDLSYNDIEDLPSFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRN-QIKFIHR 409

  Fly   295 NAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTL------KTIPSIYNFRNLQRAYLT 353
            :||..:..:|.||||..||..:|:|||..:..|.:.....|      ||:|      .|:...:.
Zfish   410 DAFLSLSALTNLDLSLNSLASVPTAGLSALNQLKLTGNMELRNGLMSKTLP------KLRSITVP 468

  Fly   354 HSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDS 418
            :::.||||                        ...||..        ||....|...:|||.:|.
Zfish   469 YAYQCCAF------------------------VAYDSAV--------NPAEDDERRNAFGGEEDM 501

  Fly   419 ATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNI-ECYPMPNDLNPC 482
                                      |:|                    |.: .|.|:|....||
Zfish   502 --------------------------ERI--------------------PMVMHCSPLPGAFKPC 520

  Fly   483 EDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVAC 547
            |.::|...:|::||.:..:|::.|..||....|.|..|....|||:..||.|:|..|:|:..:..
Zfish   521 EHLLGSWMIRLTVWFICLVALLFNCLVLAATFSPRTSSLSPSRFLVALLASANLLTGVYVAALTL 585

  Fly   548 IDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLR- 611
            :|..:.|.:..:...|:.|.||:|.|||.||:|..:|..|.:..:||.||:...|.....::.|
Zfish   586 LDTVTWGSFAEYGVWWETGAGCQVVGFLAVFSSEWAVLLLALAAVERCLAVRALMGKAGALRSRG 650

  Fly   612 ---------PAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGV 667
                     ..|.::||  :.|:..:.|.|:..|...| .:|||..........:.:|::..|.:
Zfish   651 ERRERRRRFAIAALLLG--LVSVAAACLSLYHGSAMGS-PLCLPFSEGSSPGLGFTVALVLMNTL 712

  Fly   668 AFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLI 732
            |:.:.||.|.::|..|||    |....|.:....:.:|.|:|||...:.|:|.|...     ||:
Zfish   713 AYLLSAVVYTRLYCRLGR----AQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFA-----PLL 768

  Fly   733 NVTK--------SKILLVFFYPLNSCADPYLYAILTSQYRQDLFTL--LSKLGLCQQSALKYKDS 787
            ..|.        :|.:.:.|:||::|.:|.||...:..:|.|...|  ..:.|.|.:
Zfish   769 AGTSNAVGGPEMAKSVTLIFFPLSACLNPVLYVCFSPSFRYDWLHLRGRGRTGGCGR-------- 825

  Fly   788 LSGQATTRFTIHGSIQ-----RHSSLTCKMQTVMGAETQKMLKNSE 828
            |..:..|:.|:.|...     ...|..|.|.|.:..:::.|.::.:
Zfish   826 LVAKTVTKGTVAGGSPVSDDGEGLSSDCGMYTKLHGDSRGMCEHCD 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	10/44 (23%)
		leucine-rich repeat	208..231	CDD:275380	3/29 (10%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..277	CDD:275380	6/20 (30%)
		LRR_8	258..313	CDD:290566	17/55 (31%)
		leucine-rich repeat	278..302	CDD:275380	6/23 (26%)
		leucine-rich repeat	303..323	CDD:275380	11/19 (58%)
		leucine-rich repeat	324..346	CDD:275380	5/27 (19%)
		7tm_1	505..756	CDD:278431	76/268 (28%)
lgr4	NP_001340791.1	LRR 1	58..82
		leucine-rich repeat	64..85	CDD:275380
		LRR_8	84..144	CDD:316378
		LRR 2	84..106
		leucine-rich repeat	86..109	CDD:275380
		LRR 3	107..130
		leucine-rich repeat	110..133	CDD:275380
		LRR 4	131..154
		leucine-rich repeat	134..157	CDD:275380
		LRR	137..>452	CDD:227223	77/301 (26%)
		LRR 5	156..178
		leucine-rich repeat	158..181	CDD:275380	200/826 (24%)
		LRR 6	179..202		8/28 (29%)
		leucine-rich repeat	182..205	CDD:275380	8/30 (27%)
		LRR 7	204..226		4/22 (18%)
		leucine-rich repeat	206..229	CDD:275380	5/23 (22%)
		LRR 8	227..250		7/23 (30%)
		leucine-rich repeat	230..252	CDD:275380	7/22 (32%)
		LRR_8	251..308	CDD:316378	19/70 (27%)
		LRR 9	251..273		8/34 (24%)
		leucine-rich repeat	253..276	CDD:275380	7/35 (20%)
		LRR 10	275..297		9/22 (41%)
		leucine-rich repeat	277..298	CDD:275380	8/21 (38%)
		LRR 11	299..321		2/21 (10%)
		LRR 12	322..344		1/21 (5%)
		LRR 13	345..366		7/26 (27%)
		leucine-rich repeat	348..369	CDD:275380	6/20 (30%)
		LRR 14	367..390		6/22 (27%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		LRR 15	391..414		6/23 (26%)
		leucine-rich repeat	394..415	CDD:275380	6/21 (29%)
		LRR 16	416..438		11/21 (52%)
		leucine-rich repeat	418..438	CDD:275380	11/19 (58%)
		7tmA_LGR4	527..811	CDD:320483	83/295 (28%)
		TM helix 1	528..554	CDD:320483	7/25 (28%)
		TM helix 2	562..587	CDD:320483	9/24 (38%)
		TM helix 3	607..637	CDD:320483	14/29 (48%)
		TM helix 4	649..679	CDD:320483	6/31 (19%)
		TM helix 5	698..727	CDD:320483	7/28 (25%)
		TM helix 6	736..766	CDD:320483	9/34 (26%)
		TM helix 7	779..804	CDD:320483	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910