DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr1 and rxfp2l

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_001919542.3	Gene:	rxfp2l / 558546	ZFINID:	ZDB-GENE-060531-8	Length:	692	Species:	Danio rerio

Alignment Length:	769	Identity:	167/769 - (21%)
Similarity:	290/769 - (37%)	Gaps:	224/769 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DVYPNLTAVSLAQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVP------QTLT 129
            ||||           ||            |.|       |..:..|.|..|..||      ..|.
Zfish    88 DVYP-----------DT------------CHC-------EGRKVNCNGKNLLHVPAVSSNVTALE 122

  Fly   130 LPIQRLTIASAGL-PRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKL 193
            |...|:...|..| .|.||          |:....:...:|.|...||:.|..||.::::. .|:
Zfish   123 LNSNRIESLSRDLFIRYRH----------LERLHLESNSIETISKRAFSGLVALRKLFLSQ-NKI 176

  Fly   194 TFLSKDVFLGISD-----------------------TVDIIRIINSGLTRVP--DLGHLPPHNIL 233
            :.|...:|..:|.                       ::..:.::|:.:.:.|  .:.|..|.  |
Zfish   177 SSLKAGIFSDLSSLEWLILDENRISSLRQKSFEGLKSLFFLSLLNNSVEQFPKTSICHEMPR--L 239

  Fly   234 QMIDLDNNQITRIDSKSIK--VKTAQLILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPN 295
            ..::::.|.|:.:.:.|.|  .....|.|..|.||.:::..|.. .::..|.:..| :::.:.|:
Zfish   240 NWLEMEGNIISSLWASSFKNCSSLTVLALRRNRISTIEEGTFADMQRLIDLDVSVN-QIKDLPPS 303

  Fly   296 AFDGIIDITELDLSSTSLVGLPS---AGLQNIEALYIQNTHTLKTIP--SIYNFRNLQRAYLTHS 355
            .|..:.::.:|::|:..||.:.|   ..|.|:::|.::...    ||  ||..||.|
Zfish   304 LFQNLQNLKQLNISNNPLVNIYSNQFDSLVNLQSLSMEEVE----IPNISIRMFRPL-------- 356

  Fly   356 FHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDSAT 420
                                                                            |
Zfish   357 ----------------------------------------------------------------T 357

  Fly   421 DITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNI-ECYPMPNDLNPCED 484
            ::|.|.|..|                           |.||    ..||: .|.|..:.::..|:
Zfish   358 NLTHIYFKRF---------------------------EFCG----YSPNVRSCKPNTDGISSFEN 391

  Fly   485 VMGYQWLRISVWIVVALAVVGNVAVL---TVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVA 546
            ::....||:.||:|..:...||:.|:   :.|.|.....|...:.|.|    ||..:|:|||.:.
Zfish   392 LLANIILRVFVWVVAFIICFGNIFVICLRSCIASENQHHTMAIKSLCC----ADCLMGVYLLFIG 452

  Fly   547 CIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLR 611
            ..|....|||...|..|...|.|::.|.|.:.::.:||..||.:|:|::|.|. ..:.::|...:
Zfish   453 AFDIKYCGEYNRHAQIWMESLSCQLIGSLAMLSTEVSVMMLTYMTLEKYLCIV-FPFQHYRAGRK 516

  Fly   612 PAALIMLGGWIYSMLMSSLPL-----FGISNYSSTSICLPMENRDV-------YDTIYLIAILGS 664
            .....:...|:...:::.:|.     || :.|....:|.|:.:...       |.|   ...||.
Zfish   517 QTLCSLTFIWLLGFIIAVIPFWDKQTFG-NFYGRNGVCFPLHSDQTEKPGARCYST---AIFLGL 577

  Fly   665 NGVAFSIIAVCYAQIYLSLGRETRQAHQN-SPGELSVAKKMALLVFTNFACWSPIAFFGLTALAG 728
            |.:||.:|...|:.::.|:.:..:.|.|. ...|:::||:...:|||:..||.||....:.:|.
Zfish   578 NLLAFVMIVFSYSSMFYSVQKTAKTARQTVYDREVTIAKRFFFIVFTDALCWIPIFLLKILSLL- 641

  Fly   729 YPLINVTKSKIL--LVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQS 780
              .:.:..:.||  ::|..|:||..:|.||.|.||.::|.|...|..  .|||:
Zfish   642 --RVQIAGTIILWVVIFILPINSALNPILYTITTSAFQQRLKQCLKY--RCQQT 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	6/47 (13%)
		leucine-rich repeat	208..231	CDD:275380	4/24 (17%)
		leucine-rich repeat	233..256	CDD:275380	5/24 (21%)
		leucine-rich repeat	257..277	CDD:275380	6/20 (30%)
		LRR_8	258..313	CDD:290566	12/55 (22%)
		leucine-rich repeat	278..302	CDD:275380	4/23 (17%)
		leucine-rich repeat	303..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..346	CDD:275380	6/23 (26%)
		7tm_1	505..756	CDD:278431	70/268 (26%)
rxfp2l	XP_001919542.3	LDLa	26..61	CDD:238060
		LRR_8	116..176	CDD:290566	16/70 (23%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		LRR_RI	138..>321	CDD:238064	36/196 (18%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		leucine-rich repeat	166..189	CDD:275380	5/23 (22%)
		LRR_8	188..273	CDD:290566	13/86 (15%)
		leucine-rich repeat	190..213	CDD:275380	0/22 (0%)
		leucine-rich repeat	214..238	CDD:275380	3/23 (13%)
		leucine-rich repeat	239..262	CDD:275380	5/22 (23%)
		LRR_8	261..321	CDD:290566	12/60 (20%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		LRR_4	285..324	CDD:289563	8/39 (21%)
		leucine-rich repeat	287..310	CDD:275380	4/23 (17%)
		LRR_8	310..363	CDD:290566	17/128 (13%)
		leucine-rich repeat	311..334	CDD:275380	6/22 (27%)
		leucine-rich repeat	335..356	CDD:275380	7/24 (29%)
		7tm_1	412..669	CDD:278431	70/268 (26%)
		7tm_4	<496..668	CDD:304433	42/179 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810