DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Lgr6

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	185/831 - (22%)
Similarity:	332/831 - (39%)	Gaps:	173/831 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLHHLLLTS---LSGRHFVY-ATSAVGG-------ALSANNCHDI-HHGFDVYPNLTAVSLAQST 85
            |.|||....   |||.|..: ...|..|       .|.:|....| .......|:|.::.|
  Rat    85 LFHHLRFLEELRLSGNHLSHIPRQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRL---- 145

  Fly    86 DTPLTATMPRSAWKCC-----CWNASNQAEEVECRCEGDGLNRVP--QTLTLPIQR--------- 134
            |..|.:.:|..:::..     .|...|...|:..|    .||.:|  |.:||.:.|
  Rat   146 DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR----ALNNLPALQAMTLALNRIRHIPDYAF 206

  Fly   135 -----LTIASAGLPRLRHTGLK----VYGSTLLDVAFTDCLQ--------------------LEL 170
                 |.:......|::|.|..    ::....||:.:.:..:                    ::.
  Rat   207 QNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPVAIRTLGRLQELGFHNNNIKA 271

  Fly   171 IQDGAFANLTLLRTIYITNAPKLTFLSKDVF--------LGISDTVDI----------------- 210
            |.:.||....||:||:..:.| :.|:.:..|        |.::...||
  Rat   272 IPEKAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTL 335

  Fly   211 ----IRIINSGLTRVPDLGHLPPHNILQMIDLDNNQITRIDSKSIKVKTAQLILTNNEISYVDDS 271
                ||::.:|:.:     .||.   |::::|.:|||..:.|.....|..::.|.:|.|..:...
  Rat   336 TRAGIRLLPAGMCQ-----QLPR---LRILELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGAD 392

  Fly   272 AFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTL 335
            .|.. |.:..|.|..| .::.:||.||..:..:.:|||:...|..||.|||..:..|.::....|
  Rat   393 TFSQLSSLQALDLSWN-AIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLAL 456

  Fly   336 KTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLD 400
            ....|..:|..|:...:.:::.|||:..            .....|...|.:::....:|.....
  Rat   457 SQAFSKDSFPKLRILEVPYAYQCCAYGL------------CANFFKTSGQWQAEDFHAEEEEAPK 509

  Fly   401 NPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTF 465
            .|      .|...|..::..|:      ..|.:..:|               :||...
  Rat   510 RP------LGLLAGQAENHYDL------DLDELQMET---------------EDSKPH------- 540

  Fly   466 RKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCH 530
              |:::|.|:|....|||.:.....:|::||.:|.|:|:.|..||..:.:..|......:.::..
  Rat   541 --PSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPSPLSPVKLVVGA 603

  Fly   531 LAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERW 595
            :|.|:...|:...|:|.:||.:.|::..:...|:.||||:..|||.|..|..||..||:..::..
  Rat   604 IAGANALTGISCGLLASVDALTFGQFAEYGARWETGLGCQATGFLAVLGSEASVLLLTLAAVQCS 668

  Fly   596 LAITQAMYLNHRI---KLRPAAL--IMLGGWIYSMLMSSLPLFGISNYSSTSICLPM---ENRDV 652
            :::|.........   .:|..||  :.|.|     |.::|||..:..|.::.:|||.   |.|..
  Rat   669 VSVTCVRAYGKAPSPGSVRAGALGCLALAG-----LAAALPLASVGEYGASPLCLPYAPPEGRPA 728

  Fly   653 YDTIYLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSP 717
             ...:.:|::..|.:.|.::|..|.::|..|.|...:|    ..:.::.:.:|.|:|.:...:.|
  Rat   729 -ALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEA----VWDCAMVRHVAWLIFADGLLYCP 788

  Fly   718 IAFFGLTALAG-YPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDL 767
            :||....::.| :|:.......:|||.. ||.:|.:|.||.:....:|:||
  Rat   789 VAFLSFASMLGLFPVTPEAVKSVLLVVL-PLPACLNPLLYLLFNPHFREDL 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	7/32 (22%)
		leucine-rich repeat	208..231	CDD:275380	7/43 (16%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..277	CDD:275380	4/20 (20%)
		LRR_8	258..313	CDD:290566	15/55 (27%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	9/19 (47%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		7tm_1	505..756	CDD:278431	66/259 (25%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470
		LRR_RI	<70..248	CDD:238064	36/170 (21%)
		leucine-rich repeat	70..91	CDD:275380	4/5 (80%)
		LRR_8	92..150	CDD:290566	13/61 (21%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		leucine-rich repeat	116..139	CDD:275380	3/22 (14%)
		LRR_8	138..198	CDD:290566	16/67 (24%)
		leucine-rich repeat	140..163	CDD:275380	5/26 (19%)
		leucine-rich repeat	164..187	CDD:275380	6/26 (23%)
		LRR_8	186..246	CDD:290566	11/59 (19%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		leucine-rich repeat	236..258	CDD:275380	2/21 (10%)
		LRR_RI	253..>442	CDD:238064	44/198 (22%)
		LRR_8	258..314	CDD:290566	11/56 (20%)
		leucine-rich repeat	259..282	CDD:275380	3/22 (14%)
		leucine-rich repeat	283..304	CDD:275380	6/21 (29%)
		LRR_8	305..364	CDD:290566	11/66 (17%)
		leucine-rich repeat	330..344	CDD:275378	2/13 (15%)
		leucine-rich repeat	354..375	CDD:275380	6/20 (30%)
		LRR_8	375..434	CDD:290566	16/59 (27%)
		leucine-rich repeat	376..399	CDD:275380	4/22 (18%)
		leucine-rich repeat	400..421	CDD:275380	7/21 (33%)
		leucine-rich repeat	424..444	CDD:275380	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810