DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr1 and LHCGR

DIOPT Version :9

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:NP_000224.2 Gene:LHCGR / 3973 HGNCID:6585 Length:699 Species:Homo sapiens


Alignment Length:748 Identity:274/748 - (36%)
Similarity:400/748 - (53%) Gaps:102/748 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAG---LPRLRHTGL 150
            |...:||:..:..|        ...|.|..||..|.|.. |..:.||::|...   :|.....||
Human    17 LQPPLPRALREALC--------PEPCNCVPDGALRCPGP-TAGLTRLSLAYLPVKVIPSQAFRGL 72

  Fly   151 KVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRIIN 215
                :.::.:..:....||.|:..||.||..|..|.|.|...|.::....|:.: ..:..:.|.|
Human    73 ----NEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINL-PRLKYLSICN 132

  Fly   216 SGLTRVPDLGHL---PPHNILQMID------LDNNQITRIDSKSIKVKTAQLILTNNEISYVDDS 271
            :|:.:.||:..:   ..:.||::.|      :..|....::::|:.:|     |..|....|...
Human   133 TGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK-----LYGNGFEEVQSH 192

  Fly   272 AFFGSKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLK 336
            ||.|:.:..|.||||..|:.||..||.|......||:|||.|..|||.||::|:.|...::::||
Human   193 AFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLK 257

  Fly   337 TIPSIYNFRNLQRAYLTHSFHCCAFQ-FPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLD 400
            .:||...|.||..|.||:..|||||: .|::.....|:..    |.:.|||  :|..||      
Human   258 KLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSIS----ENFSKQC--ESTVRK------ 310

  Fly   401 NPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCG---N 462
                                                 :|..|.:..::      :.:||.|   .
Human   311 -------------------------------------VNNKTLYSSML------AESELSGWDYE 332

  Fly   463 FTFRKPNI-ECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRF 526
            :.|..|.. .|.|.|:..|||||:|||.:||:.:|::..||::||:.||.|:|:.|.:.| ||||
Human   333 YGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLT-VPRF 396

  Fly   527 LMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVIT 591
            |||:|:|||.|:||||||:|.:|:.:.|:|:|.|.|||.|.||..|||.|||||.|||:||||||
Human   397 LMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVIT 461

  Fly   592 IERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTI 656
            :|||..||.|::|:.:::||.|.|||||||::|.|::.|||.|:|||...|||.||:.......:
Human   462 LERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQV 526

  Fly   657 YLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFF 721
            |::.||..|.|||.||..||.:||.::......|...   :..:|||||:|:||:|.|.:||:||
Human   527 YILTILILNVVAFFIICACYIKIYFAVRNPELMATNK---DTKIAKKMAILIFTDFTCMAPISFF 588

  Fly   722 GLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSALKYK- 785
            .::|....|||.||.||:|||.|||:||||:|:||||.|..:::|.|.||||.|.|::.|..|: 
Human   589 AISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRR 653

  Fly   786 ---DSLSGQATTRFTIHGSIQRHSSLTCKMQTV 815
               .:.:......||  || .:.|..|.|:.|:
Human   654 KDFSAYTSNCKNGFT--GS-NKPSQSTLKLSTL 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 leucine-rich repeat 182..207 CDD:275380 6/24 (25%)
leucine-rich repeat 208..231 CDD:275380 5/25 (20%)
leucine-rich repeat 233..256 CDD:275380 5/28 (18%)
leucine-rich repeat 257..277 CDD:275380 6/19 (32%)
LRR_8 258..313 CDD:290566 22/54 (41%)
leucine-rich repeat 278..302 CDD:275380 11/23 (48%)
leucine-rich repeat 303..323 CDD:275380 11/19 (58%)
leucine-rich repeat 324..346 CDD:275380 7/21 (33%)
7tm_1 505..756 CDD:278431 133/250 (53%)
LHCGRNP_000224.2 leucine-rich repeat 51..74 CDD:275380 6/26 (23%)
LRR_5 62..198 CDD:290045 33/145 (23%)
leucine-rich repeat 75..99 CDD:275380 7/23 (30%)
LRR 1 96..115 7/18 (39%)
leucine-rich repeat 100..124 CDD:275380 6/24 (25%)
LRR 2 124..145 5/20 (25%)
leucine-rich repeat 125..150 CDD:275380 5/24 (21%)
LRR 3 149..171 4/21 (19%)
leucine-rich repeat 151..174 CDD:275380 4/22 (18%)
leucine-rich repeat 175..198 CDD:275380 8/27 (30%)
LRR 4 175..196 7/25 (28%)
LRR 5 198..220 10/21 (48%)
leucine-rich repeat 199..223 CDD:275380 11/23 (48%)
LRR 6 223..244 11/20 (55%)
leucine-rich repeat 224..244 CDD:275380 11/19 (58%)
7tm_1 376..623 CDD:278431 133/250 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158088
Domainoid 1 1.000 279 1.000 Domainoid score I1700
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37276
Inparanoid 1 1.050 435 1.000 Inparanoid score I1705
Isobase 1 0.950 - 0 Normalized mean entropy S5552
OMA 1 1.010 - - QHG51461
OrthoDB 1 1.010 - - D136124at33208
OrthoFinder 1 1.000 - - FOG0001622
OrthoInspector 1 1.000 - - otm40601
orthoMCL 1 0.900 - - OOG6_104064
Panther 1 1.100 - - O PTHR24372
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3294
SonicParanoid 1 1.000 - - X1188
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

Return to query results.
Submit another query.