DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and LHCGR

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:NP_000224.2 Gene:LHCGR / 3973 HGNCID:6585 Length:699 Species:Homo sapiens


Alignment Length:748 Identity:274/748 - (36%)
Similarity:400/748 - (53%) Gaps:102/748 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAG---LPRLRHTGL 150
            |...:||:..:..|        ...|.|..||..|.|.. |..:.||::|...   :|.....||
Human    17 LQPPLPRALREALC--------PEPCNCVPDGALRCPGP-TAGLTRLSLAYLPVKVIPSQAFRGL 72

  Fly   151 KVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRIIN 215
                :.::.:..:....||.|:..||.||..|..|.|.|...|.::....|:.: ..:..:.|.|
Human    73 ----NEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINL-PRLKYLSICN 132

  Fly   216 SGLTRVPDLGHL---PPHNILQMID------LDNNQITRIDSKSIKVKTAQLILTNNEISYVDDS 271
            :|:.:.||:..:   ..:.||::.|      :..|....::::|:.:|     |..|....|...
Human   133 TGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK-----LYGNGFEEVQSH 192

  Fly   272 AFFGSKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLK 336
            ||.|:.:..|.||||..|:.||..||.|......||:|||.|..|||.||::|:.|...::::||
Human   193 AFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLK 257

  Fly   337 TIPSIYNFRNLQRAYLTHSFHCCAFQ-FPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLD 400
            .:||...|.||..|.||:..|||||: .|::.....|:..    |.:.|||  :|..||      
Human   258 KLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSIS----ENFSKQC--ESTVRK------ 310

  Fly   401 NPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCG---N 462
                                                 :|..|.:..::      :.:||.|   .
Human   311 -------------------------------------VNNKTLYSSML------AESELSGWDYE 332

  Fly   463 FTFRKPNI-ECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRF 526
            :.|..|.. .|.|.|:..|||||:|||.:||:.:|::..||::||:.||.|:|:.|.:.| ||||
Human   333 YGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLT-VPRF 396

  Fly   527 LMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVIT 591
            |||:|:|||.|:||||||:|.:|:.:.|:|:|.|.|||.|.||..|||.|||||.|||:||||||
Human   397 LMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVIT 461

  Fly   592 IERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTI 656
            :|||..||.|::|:.:::||.|.|||||||::|.|::.|||.|:|||...|||.||:.......:
Human   462 LERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQV 526

  Fly   657 YLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFF 721
            |::.||..|.|||.||..||.:||.::......|...   :..:|||||:|:||:|.|.:||:||
Human   527 YILTILILNVVAFFIICACYIKIYFAVRNPELMATNK---DTKIAKKMAILIFTDFTCMAPISFF 588

  Fly   722 GLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSALKYK- 785
            .::|....|||.||.||:|||.|||:||||:|:||||.|..:::|.|.||||.|.|::.|..|: 
Human   589 AISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRR 653

  Fly   786 ---DSLSGQATTRFTIHGSIQRHSSLTCKMQTV 815
               .:.:......||  || .:.|..|.|:.|:
Human   654 KDFSAYTSNCKNGFT--GS-NKPSQSTLKLSTL 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 63/200 (32%)
leucine-rich repeat 182..207 CDD:275380 6/24 (25%)
leucine-rich repeat 208..231 CDD:275380 5/25 (20%)
leucine-rich repeat 233..256 CDD:275380 5/28 (18%)
leucine-rich repeat 257..277 CDD:275380 6/19 (32%)
leucine-rich repeat 278..302 CDD:275380 11/23 (48%)
leucine-rich repeat 303..323 CDD:275380 11/19 (58%)
leucine-rich repeat 324..346 CDD:275380 7/21 (33%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 143/276 (52%)
TM helix 1 490..516 CDD:320264 11/25 (44%)
TM helix 2 524..549 CDD:320264 18/24 (75%)
TM helix 3 569..599 CDD:320264 21/29 (72%)
TM helix 4 611..633 CDD:320264 13/21 (62%)
TM helix 5 653..682 CDD:320264 13/28 (46%)
TM helix 6 692..725 CDD:320264 14/32 (44%)
TM helix 7 735..760 CDD:320264 18/24 (75%)
LHCGRNP_000224.2 leucine-rich repeat 51..74 CDD:275380 6/26 (23%)
LRR_5 62..198 CDD:463839 33/145 (23%)
leucine-rich repeat 75..99 CDD:275380 7/23 (30%)
LRR 1 96..115 7/18 (39%)
leucine-rich repeat 100..124 CDD:275380 6/24 (25%)
LRR 2 124..145 5/20 (25%)
leucine-rich repeat 125..150 CDD:275380 5/24 (21%)
LRR 3 149..171 4/21 (19%)
leucine-rich repeat 151..174 CDD:275380 4/22 (18%)
leucine-rich repeat 175..198 CDD:275380 8/27 (30%)
LRR 4 175..196 7/25 (28%)
LRR 5 198..220 10/21 (48%)
leucine-rich repeat 199..223 CDD:275380 11/23 (48%)
LRR 6 223..244 11/20 (55%)
leucine-rich repeat 224..244 CDD:275380 11/19 (58%)
7tmA_LHCGR 360..634 CDD:320481 143/277 (52%)
TM helix 1 361..387 CDD:320481 11/25 (44%)
TM helix 2 394..419 CDD:320481 18/24 (75%)
TM helix 3 439..469 CDD:320481 21/29 (72%)
TM helix 4 481..503 CDD:320481 13/21 (62%)
TM helix 5 523..552 CDD:320481 13/28 (46%)
TM helix 6 562..592 CDD:320481 14/32 (44%)
TM helix 7 602..627 CDD:320481 18/24 (75%)

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