DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and Rxfp1

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:NP_997617.1 Gene:Rxfp1 / 381489 MGIID:2682211 Length:758 Species:Mus musculus


Alignment Length:794 Identity:177/794 - (22%)
Similarity:306/794 - (38%) Gaps:230/794 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 GGALSANNCHDIHHGFDV---------YPNLTAVSLAQSTDTPLTATMPRSAWKCCCWNASNQAE 110
            |.....::|.| ::|:.:         |...:..|....|...|..::|   ..|.|       .
Mouse    54 GNRADEDHCGD-NNGWSLQLDKYFANYYKLASTNSFEAETSECLVGSVP---MHCLC-------R 107

  Fly   111 EVECRCEGDGLNRVP----QTLTLPIQRLTIASAGLP----RLRHTGLKVYGSTLLDVAFTDCLQ 167
            ::|..|:...|..||    ....:.:||..|.:  ||    |..|...|:            |||
Mouse   108 DLELDCDEANLRAVPSVSSNVTVMSLQRNFIRT--LPPNGFRKYHELQKL------------CLQ 158

  Fly   168 ---LELIQDGAFANLTLLRTIYITNAPKLTFLSKDVF--------LGISD--------------- 206
               :..:...||..|..|..:|::: .::|||...||        |.|.|               
Mouse   159 NNRIHSVSVSAFRGLRSLTKLYLSH-NRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTFYGLN 222

  Fly   207 TVDIIRIINSGLTRVPD---LGHLPPHNILQMIDLDNNQI------TRIDSKSIKVKTAQLILTN 262
            ::.::.::|:.|||:||   ..|:|.   |..:|.:.|:|      |.|...::.|    |::..
Mouse   223 SLILLVLMNNALTRLPDKPLCQHMPR---LHWLDFEGNRIHNLRNLTFISCNNLTV----LVMRK 280

  Fly   263 NEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEA 326
            |:|:|:::.||.. .|:.:|.|..| |::.:.||.|..:.::::|::|...        :|.|| 
Mouse   281 NKINYLNEHAFTHLQKLDELDLGSN-KIENLPPNIFKDLKELSQLNISYNP--------IQKIE- 335

  Fly   327 LYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSG 391
                                      .:.|.|.|                        :.||.|.
Mouse   336 --------------------------VNQFDCLA------------------------KLKSLSL 350

  Fly   392 TRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSS 456
            ...|.|.:......|            ..:::.|.|..|.|                        
Mouse   351 EGIEISNIQQRMFRP------------LINLSHIYFKKFQY------------------------ 379

  Fly   457 AELCGNFTFRKPNI-ECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPES 520
               ||    ..|:: .|.|..:.::..|:::.....|:.||:|.|:...||:.|:.:...||.|:
Mouse   380 ---CG----YAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAITCFGNIFVICMRPYIRSEN 437

  Fly   521 TPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVF 585
             .:....:..|..||..:|:||.::...|....|||...|..|...:.|:..|.|.:.::.:||.
Mouse   438 -KLHAMSIISLCCADCLMGVYLFVIGAFDLKFRGEYNKHAQPWMESVHCQFMGSLAILSTEVSVL 501

  Fly   586 TLTVITIERWLAITQAMYLNHRIKLRP------AALIMLGGWIYSMLMSSLPL----FGISNYSS 640
            .||.:|:|:::.|......     |||      ..||.:  ||...:::..||    |..:.|.:
Mouse   502 LLTFLTLEKYICIVYPFRC-----LRPRKCRTITVLIFI--WIIGFIVAFAPLGNKEFFKNYYGT 559

  Fly   641 TSICLPMENRDVYDT---IYLIAI-LGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNS------- 694
            ..:|.|:.:.|...|   ||.:.| ||.|.|||.||...|..::.|:       ||:|       
Mouse   560 NGVCFPLHSEDTGSTGAQIYSVVIFLGINLVAFIIIVFSYGSMFYSV-------HQSSVTVTEIQ 617

  Fly   695 ---PGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLY 756
               ..|:.:||:...:|||:..||.||......:|....:.:...|.: ::|..|:||..:|.:|
Mouse   618 KQVKKEVVLAKRFFFIVFTDALCWIPIFILKFLSLLQVEIPDSITSWV-VIFILPINSALNPIIY 681

  Fly   757 AILTSQYRQDLFTL 770
            .:.|..:::.:..|
Mouse   682 TLTTRPFKEMIHQL 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 50/227 (22%)
leucine-rich repeat 182..207 CDD:275380 10/47 (21%)
leucine-rich repeat 208..231 CDD:275380 8/25 (32%)
leucine-rich repeat 233..256 CDD:275380 7/28 (25%)
leucine-rich repeat 257..277 CDD:275380 6/20 (30%)
leucine-rich repeat 278..302 CDD:275380 7/23 (30%)
leucine-rich repeat 303..323 CDD:275380 2/19 (11%)
leucine-rich repeat 324..346 CDD:275380 2/21 (10%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 83/300 (28%)
TM helix 1 490..516 CDD:320264 8/25 (32%)
TM helix 2 524..549 CDD:320264 6/24 (25%)
TM helix 3 569..599 CDD:320264 9/29 (31%)
TM helix 4 611..633 CDD:320264 8/31 (26%)
TM helix 5 653..682 CDD:320264 13/32 (41%)
TM helix 6 692..725 CDD:320264 12/42 (29%)
TM helix 7 735..760 CDD:320264 7/24 (29%)
Rxfp1NP_997617.1 LDLa 27..62 CDD:238060 1/7 (14%)
leucine-rich repeat 110..127 CDD:275378 5/16 (31%)
LRR 1 127..148 5/22 (23%)
leucine-rich repeat 128..151 CDD:275380 6/24 (25%)
LRR <143..>360 CDD:443914 61/296 (21%)
LRR 2 151..172 6/32 (19%)
leucine-rich repeat 152..175 CDD:275380 7/34 (21%)
LRR 3 175..196 7/21 (33%)
leucine-rich repeat 176..199 CDD:275380 7/23 (30%)
LRR 4 199..220 3/20 (15%)
leucine-rich repeat 200..223 CDD:275380 3/22 (14%)
LRR 5 223..244 6/20 (30%)
leucine-rich repeat 224..248 CDD:275380 7/23 (30%)
LRR 6 248..269 5/23 (22%)
leucine-rich repeat 249..272 CDD:275380 6/22 (27%)
LRR 7 272..293 7/24 (29%)
leucine-rich repeat 273..296 CDD:275380 7/26 (27%)
LRR 8 296..317 8/21 (38%)
leucine-rich repeat 297..320 CDD:275380 7/23 (30%)
LRR 9 320..341 6/55 (11%)
leucine-rich repeat 321..344 CDD:275380 8/81 (10%)
LRR 10 344..365 5/20 (25%)
leucine-rich repeat 345..366 CDD:275380 6/32 (19%)
7tmA_RXFP1_LGR7 406..692 CDD:320631 83/301 (28%)
TM helix 1 407..433 CDD:320631 8/25 (32%)
TM helix 2 440..465 CDD:320631 6/24 (25%)
TM helix 3 485..515 CDD:320631 9/29 (31%)
TM helix 4 526..548 CDD:320631 5/23 (22%)
TM helix 5 576..605 CDD:320631 12/28 (43%)
TM helix 6 621..651 CDD:320631 10/29 (34%)
TM helix 7 660..685 CDD:320631 7/25 (28%)

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