DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Rxfp2

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001012493.1	Gene:	Rxfp2 / 363866	RGDID:	1309449	Length:	737	Species:	Rattus norvegicus

Alignment Length:	833	Identity:	188/833 - (22%)
Similarity:	321/833 - (38%)	Gaps:	235/833 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LLLHHLLLT-----SLSGRHFV------------YATSAVGGALSANNCHDIHHGFD-------- 71
            ||||.:||.     :|:|.:.|            ..|..:..|...:...|..:|.|
  Rat     3 LLLHVVLLMEVKDFTLAGSNMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTS 67

  Fly    72 --------VYPNLTAVSLAQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTL 128
                    |:.|:..|:|.:.      ..:.|....|.|       .|.|..|....|..||:..
  Rat    68 GWTTIFGTVHGNVNKVTLTEE------CFLSRYPQHCYC-------RENELECVNADLKAVPKVS 119

  Fly   129 TLPIQRLTIASAGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKL 193
            :    .:|:.|....::....:||                       |:....||.|::.: ..:
  Rat   120 S----NVTLLSLKKNKIHRLPVKV-----------------------FSKYAELRKIFLQH-NCI 156

  Fly   194 TFLSKDVFLGISDTVDIIRIINSGLTRV-----PDLGHLPPHNILQMIDLDNNQITRIDSKS--- 250
            |.:|:..|||:.: :.|:.:.::.:|.:     .||     |.:..:| ||:|.||||..:|
  Rat   157 THISRRAFLGLHN-LQILYLSHNCITSLRPGIFKDL-----HQLAWLI-LDDNPITRISQRSFTG 214

  Fly   251 --------------------IKVKTAQL---ILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQM 291
                                :..:..||   .|.||.|.::.:|.|.. ..:..|.|..| ::..
  Rat   215 LNSLFFLSMVSNRLEALPERLCAQMPQLNWVDLANNGIKFITNSTFLTCDSLTVLFLPRN-QIGF 278

  Fly   292 MHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSF 356
            :....|..:.::.||||||..:..||:....::..|...|   |.:.|.:|..:|
  Rat   279 VPEKTFSSLKNLGELDLSSNVIAKLPAHLFSDLHLLQKLN---LSSNPLLYVHKN---------- 330

  Fly   357 HCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLD-NPFNMPE-DFGSFGGTDDSA 419
                 ||                           |:.|:..:|| ....:|. :.|.|
  Rat   331 -----QF---------------------------GSLKQLQSLDLERIEIPNINTGMF------- 356

  Fly   420 TDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFR----KPNIE-CYPMPNDL 479
               .|:...|..|:.                             |||    .|::. |.|..:.:
  Rat   357 ---RPMKNLSHIYLK-----------------------------TFRYCSYVPHVRICMPSTDGI 389

  Fly   480 NPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVP---RFLMCHLAFADLCLGLY 541
            :..||::....||:|||::..:...||..|:.|...|:.|:|...   :.|.|    ||..:|:|
  Rat   390 SSSEDLLANSILRVSVWVIAFITCAGNFLVIAVRSLIKAENTTHAMSIKILCC----ADCLMGVY 450

  Fly   542 LLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNH 606
            |..|...|....|:|..:|..|...:.|::.|||...::.:||..||.:|:|::|.|. ..:.|.
  Rat   451 LFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIV-FPFSNL 514

  Fly   607 RIKLRPAALIMLGGWIYSMLMSSLPL-----FGISNYSSTSICLPMENRDVYDTI-------YLI 659
            |:..|..|:::...|:...|::::|.     || :.|....:|.|:.    ||..       |.:
  Rat   515 RLGKRQTAVVLASIWVAGFLIAAVPFTSEDYFG-NFYGKNGVCFPLH----YDQAEDFGSRGYSL 574

  Fly   660 AI-LGSNGVAFSIIAVCYAQIYLSLGR---ETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAF 720
            .| ||.|.:||.:|...|..::.|:.:   :|.:...:...|::||.:...:||::..||.|:..
  Rat   575 GIFLGVNLLAFLVITFSYVTMFCSIQKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFV 639

  Fly   721 FGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSK 773
            ..:.:|....:.....|.| :|||.|:||..:|.||.:.||.::..|..||.|
  Rat   640 VKILSLLQVEIPGTITSWI-VVFFLPVNSALNPILYTLTTSLFKDKLKQLLHK 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	8/24 (33%)
		leucine-rich repeat	208..231	CDD:275380	4/27 (15%)
		leucine-rich repeat	233..256	CDD:275380	9/45 (20%)
		leucine-rich repeat	257..277	CDD:275380	8/23 (35%)
		LRR_8	258..313	CDD:290566	17/58 (29%)
		leucine-rich repeat	278..302	CDD:275380	4/23 (17%)
		leucine-rich repeat	303..323	CDD:275380	8/19 (42%)
		leucine-rich repeat	324..346	CDD:275380	5/21 (24%)
		7tm_1	505..756	CDD:278431	75/269 (28%)
Rxfp2	NP_001012493.1	LDLa	28..63	CDD:238060	5/34 (15%)
		leucine-rich repeat	96..121	CDD:275380	8/35 (23%)
		leucine-rich repeat	122..145	CDD:275380	5/45 (11%)
		LRR_RI	134..343	CDD:238064	56/285 (20%)
		LRR_8	145..204	CDD:290566	17/66 (26%)
		leucine-rich repeat	146..169	CDD:275380	8/23 (35%)
		leucine-rich repeat	170..193	CDD:275380	4/27 (15%)
		LRR_8	193..252	CDD:290566	14/59 (24%)
		leucine-rich repeat	194..217	CDD:275380	9/23 (39%)
		leucine-rich repeat	218..241	CDD:275380	0/22 (0%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		LRR_8	265..324	CDD:290566	15/62 (24%)
		leucine-rich repeat	266..289	CDD:275380	4/23 (17%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		LRR_8	314..367	CDD:290566	17/107 (16%)
		leucine-rich repeat	314..337	CDD:275380	9/67 (13%)
		leucine-rich repeat	338..357	CDD:275380	5/28 (18%)
		7tm_1	415..674	CDD:278431	75/269 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810