DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and rk

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:828 Identity:243/828 - (29%)
Similarity:385/828 - (46%) Gaps:170/828 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GLKCLSFEFQCRLLLHHLLLTSLSGRHFVYATSAVGGALSANNCHDIHHGFDVYPNLTAVSLAQS 84
            ||:.|.     .|.|...|||.::...|....:.:...|..|....|..|  ...||||:.:.:.
  Fly   297 GLRTLE-----ALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAG--ALKNLTALKVLEL 354

  Fly    85 TDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAGLPRLRHTG 149
            .|. |.:::|                        :||:::.|     :|.|:|.|..|..:..|.
  Fly   355 DDN-LISSLP------------------------EGLSKLSQ-----LQELSITSNRLRWINDTE 389

  Fly   150 LKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRII 214
            |. ....:||:...   .|..|..|||..::.||.:.:::...|....:   |.....::|:::.
  Fly   390 LP-RSMQMLDMRAN---PLSTISPGAFRGMSKLRKLILSDVRTLRSFPE---LEACHALEILKLD 447

  Fly   215 NSGLTRVP------------------DLGHLPPHNI-----LQMIDLDNNQITRIDSKSIK--VK 254
            .:|:..||                  .|..:|  |:     |:::||.:|||.:|..|...  .:
  Fly   448 RAGIQEVPANLCRQTPRLKSLELKTNSLKRIP--NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQ 510

  Fly   255 TAQLILTNNEISYVDDSAFFGSKIAKLSL--KENKKLQMMHPNAFDGIIDITELDLSSTSLVGLP 317
            ...|:|:.|.|..:...||.|  |.||.|  .|..::..:|..||.|...:.:|:|.:.....||
  Fly   511 LNDLLLSYNRIKALPQDAFQG--IPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP 573

  Fly   318 SAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAF-------------------QF 363
            .:||:.:..|...|...|:..|....|..:|...|::::|||||                   .|
  Fly   574 ESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLF 638

  Fly   364 P------------------------------SRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERST 398
            |                              |.|||...|....|     :|.::.:|.:...|.
  Fly   639 PSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNE-----EQLQTQTGGQIATSY 698

  Fly   399 LDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNF 463
            ::..|...:..|             |.|...|        ..|.|         ...|.|     
  Fly   699 MEEYFEEHDVSG-------------PATGYGF--------GTGLF---------SGMSTE----- 728

  Fly   464 TFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLM 528
            .|:..:::|.|||....||.|:..:..||..||:|..|:::||..|:.|:|..| ....|||||:
  Fly   729 DFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSR-SKMDVPRFLV 792

  Fly   529 CHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIE 593
            |:||.||..:|:||.::|.:||.::||:..||..||..:.|:::|||.|.:|.|||:||.|||:|
  Fly   793 CNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLE 857

  Fly   594 RWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTI-Y 657
            |..|||.|::||.|:.|:.|..||..||:::::|:.:||.|:|:|...::|||.|......:: |
  Fly   858 RNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTY 922

  Fly   658 LIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFG 722
            :|:::..||.||..:..||.::|.::    |.:...:..:..:||:|||||||:|.||||||||.
  Fly   923 VISLMFINGCAFLTLMGCYLKMYWAI----RGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFS 983

  Fly   723 LTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTL 770
            :||:.|..||::.::||..||..|||||.:|:||||:|.|:::|..||
  Fly   984 ITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTL 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 53/218 (24%)
leucine-rich repeat 182..207 CDD:275380 4/24 (17%)
leucine-rich repeat 208..231 CDD:275380 6/40 (15%)
leucine-rich repeat 233..256 CDD:275380 8/24 (33%)
leucine-rich repeat 257..277 CDD:275380 7/19 (37%)
leucine-rich repeat 278..302 CDD:275380 9/25 (36%)
leucine-rich repeat 303..323 CDD:275380 6/19 (32%)
leucine-rich repeat 324..346 CDD:275380 5/21 (24%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 122/277 (44%)
TM helix 1 490..516 CDD:320264 11/25 (44%)
TM helix 2 524..549 CDD:320264 13/24 (54%)
TM helix 3 569..599 CDD:320264 17/29 (59%)
TM helix 4 611..633 CDD:320264 7/21 (33%)
TM helix 5 653..682 CDD:320264 9/29 (31%)
TM helix 6 692..725 CDD:320264 18/32 (56%)
TM helix 7 735..760 CDD:320264 14/24 (58%)
rkNP_476702.1 LRR <157..390 CDD:443914 29/129 (22%)
leucine-rich repeat 158..179 CDD:275380
leucine-rich repeat 183..204 CDD:275380
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380 2/2 (100%)
LRR 292..612 CDD:443914 85/362 (23%)
leucine-rich repeat 301..324 CDD:275380 7/27 (26%)
leucine-rich repeat 325..348 CDD:275380 6/24 (25%)
leucine-rich repeat 349..371 CDD:275380 5/46 (11%)
leucine-rich repeat 372..393 CDD:275380 7/21 (33%)
leucine-rich repeat 394..415 CDD:275380 7/23 (30%)
leucine-rich repeat 418..486 CDD:275380 11/72 (15%)
leucine-rich repeat 441..464 CDD:275378 4/22 (18%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 8/24 (33%)
leucine-rich repeat 535..558 CDD:275380 7/22 (32%)
leucine-rich repeat 559..580 CDD:275380 6/20 (30%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 122/278 (44%)
TM helix 1 755..781 CDD:320264 11/25 (44%)
TM helix 2 788..813 CDD:320264 13/24 (54%)
TM helix 3 833..863 CDD:320264 17/29 (59%)
TM helix 4 875..897 CDD:320264 7/21 (33%)
TM helix 5 918..947 CDD:320264 9/28 (32%)
TM helix 6 956..986 CDD:320264 18/29 (62%)
TM helix 7 996..1021 CDD:320264 14/24 (58%)
Blue background indicates that the domain is not in the aligned region.

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