Protein Alignment Lgr1 and Lgr6

DIOPT Version :10

• Sequence 1: NP_524393.2
• Gene: Lgr1 / 42133
• FlyBaseID: FBgn0016650
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001405234.1
• Gene: Lgr6 / 329252
• MGIID: 2441805
• Length: 1004
• Species: Mus musculus
• Alignment Length: 870
• Identity: 190/870 - (21%)
• Similarity: 333/870 - (38%)
• Gaps: 214/870 - (24%)

  Fly    33 LLHHLLLTS---LSGRHFVYAT-SAVGG-------ALSANNCHDI-HHGFDVYPNLTAVSLAQST 85
            |.|||....   |||.|..:.. .|..|       .|.:|....| .......|:|.::.|
Mouse    85 LFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRL---- 145

  Fly    86 DTPLTATMPRSAWKCC-----CWNASNQAEEVECRCEGDGLNRVP--QTLTLPI----------- 132
            |..|.:.:|..:::..     .|...|...|:..|    .||.:|  |.:||.:
Mouse   146 DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR----ALNNLPALQAMTLALNHIRHIPDYAF 206

  Fly   133 QRLT---IASAGLPRLRHTGLKVY----------------------------------------- 153
            |.||   :......|::|.|...:
Mouse   207 QNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLVFFLFCSPERFLGEPAGEGRCGGGGAAARMKG 271

  Fly   154 GSTLLDVAFTDCLQLEL--------------------IQDGAFANLTLLRTIYITNAPKLTFLSK 198
            |....|:.:.:..:..|                    |.:.||....||:||:..:.| :.|:.:
Mouse   272 GRNDRDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNP-IQFVGR 335

  Fly   199 DVFL-----------GISD-----------TVDIIRIINSGLTRVPD--LGHLPPHNILQMIDLD 239
            ..|.           |.:|           :::|:.:..:|:..:|.  ...||.   |::::|.
Mouse   336 SAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPR---LRILELS 397

  Fly   240 NNQITRIDSKSIKVKTAQLILTNNEISYVDDSAF--FGSKIAKLSLKENKKLQMMHPNAFDGIID 302
            :|||..:.|.....|..::.|.:|.|..:....|  .|| :..|.|..| .::.:||.||..:..
Mouse   398 HNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGS-LQALDLSWN-AIRAIHPEAFSTLRS 460

  Fly   303 ITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRH 367
            :.:|||:...|..||.|||..:..|.::....|....|..:|..|:...:.:::.|||:..
Mouse   461 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCAYGI---- 521

  Fly   368 DPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPED------FGSFGGTDDSATDITPIT 426
                              |.|...|..:....|  |:..|:      .|...|..::..|:..
Mouse   522 ------------------CASFFKTSGQWQAED--FHPEEEEAPKRPLGLLAGQAENHYDLDL-- 564

  Fly   427 FASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWL 491
                     |.:..||          :||...         |:::|.|:|....|||.:.....:
Mouse   565 ---------DELQMGT----------EDSKPH---------PSVQCSPVPGPFKPCEHLFESWGI 601

  Fly   492 RISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEY 556
            |::||.:|.|:|:.|..||..:.:..|......:.::..:|.|:...|:...|:|.:||.:.|::
Mouse   602 RLAVWAIVLLSVLCNGLVLLTVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQF 666

  Fly   557 FNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRI---KLRPAAL--I 616
            ..:...|:.||||:..|||.|..|..||..||:..::..:::|.........   .:|..||  :
Mouse   667 AEYGARWESGLGCQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCL 731

  Fly   617 MLGGWIYSMLMSSLPLFGISNYSSTSICLPM---ENRDVYDTIYLIAILGSNGVAFSIIAVCYAQ 678
            .|.|     |.::|||..:..|.::.:|||.   |.|.. ...:.:|::..|.:.|.::|..|.:
Mouse   732 ALAG-----LAAALPLASVGEYGASPLCLPYAPPEGRPA-ALGFAVALVMMNSLCFLVVAGAYIK 790

  Fly   679 IYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFGLTALAG-YPLINVTKSKILLV 742
            :|..|.|...:|    ..:.::.:.:|.|:|.:...:.|:||....::.| :|:.......:|||
Mouse   791 LYCDLPRGDFEA----VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLV 851

  Fly   743 FFYPLNSCADPYLYAILTSQYRQDL 767
            .. ||.:|.:|.||.:....:|.||
Mouse   852 VL-PLPACLNPLLYLLFNPHFRDDL 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	LRR	<162..>354	CDD:443914	52/237 (22%)
		leucine-rich repeat	182..207	CDD:275380	8/46 (17%)
		leucine-rich repeat	208..231	CDD:275380	5/24 (21%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..277	CDD:275380	5/21 (24%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	9/19 (47%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		7tmA_Glyco_hormone_R	490..767	CDD:320264	75/285 (26%)
		TM helix 1	490..516	CDD:320264	9/25 (36%)
		TM helix 2	524..549	CDD:320264	5/24 (21%)
		TM helix 3	569..599	CDD:320264	10/29 (34%)
		TM helix 4	611..633	CDD:320264	8/23 (35%)
		TM helix 5	653..682	CDD:320264	6/28 (21%)
		TM helix 6	692..725	CDD:320264	6/32 (19%)
		TM helix 7	735..760	CDD:320264	9/24 (38%)
Lgr6	NP_001405234.1	LRR	<51..350	CDD:443914	48/273 (18%)
		leucine-rich repeat	70..91	CDD:275380	4/5 (80%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		leucine-rich repeat	116..139	CDD:275380	3/22 (14%)
		leucine-rich repeat	140..163	CDD:275380	5/26 (19%)
		leucine-rich repeat	164..187	CDD:275380	6/26 (23%)
		leucine-rich repeat	188..211	CDD:275380	5/22 (23%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	236..295	CDD:275380	3/58 (5%)
		LRR	277..>508	CDD:443914	53/236 (22%)
		leucine-rich repeat	296..319	CDD:275380	3/22 (14%)
		leucine-rich repeat	320..341	CDD:275380	6/21 (29%)
		leucine-rich repeat	344..385	CDD:275380	5/40 (13%)
		leucine-rich repeat	391..412	CDD:275380	6/20 (30%)
		leucine-rich repeat	413..436	CDD:275380	4/22 (18%)
		leucine-rich repeat	437..458	CDD:275380	7/21 (33%)
		leucine-rich repeat	461..481	CDD:275380	9/19 (47%)
		7tmA_LGR6	599..875	CDD:320484	75/286 (26%)
		TM helix 1	600..626	CDD:320484	9/25 (36%)
		TM helix 2	634..659	CDD:320484	5/24 (21%)
		TM helix 3	679..709	CDD:320484	10/29 (34%)
		TM helix 4	721..743	CDD:320484	8/26 (31%)
		TM helix 5	765..794	CDD:320484	6/29 (21%)
		TM helix 6	803..833	CDD:320484	6/29 (21%)
		TM helix 7	843..868	CDD:320484	9/25 (36%)