DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Rxfp1

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_006232570.1	Gene:	Rxfp1 / 295144	RGDID:	1302973	Length:	763	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	182/793 - (22%)
Similarity:	312/793 - (39%)	Gaps:	229/793 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GGALSANNCHDIHHGFDV--------YPNLTAV-SLAQSTDTPLTATMPRSAWKCCCWNASNQAE 110
            |.....:||.| ::|:.:        |..||:. |:...|...|..::|   ..|.|       .
  Rat    60 GNQADEDNCGD-NNGWSLQLDKYFANYYKLTSTNSIEAETSECLVGSVP---MHCLC-------R 113

  Fly   111 EVECRCEGDGLNRVPQTLTLPIQRLTIAS------AGLP----RLRHTGLKVYGSTLLDVAFTDC 165
            ::|..|:...|..||...:    .:|:.|      ..||    |:.|...|:            |
  Rat   114 DLELDCDEANLRAVPSVSS----NVTVMSLQWNFIRTLPPNSFRMYHDLQKL------------C 162

  Fly   166 LQ---LELIQDGAFANLTLLRTIYITNAPKLTFLSKDVF--------LGISD------------- 206
            ||   :..:...||..|..|..:|::: .::|||...||        |.|.|
  Rat   163 LQNNKIRSVSVSAFRGLHSLTKLYLSH-NRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTFYG 226

  Fly   207 --TVDIIRIINSGLTRVPD---LGHLPPHNILQMIDLDNNQI------TRIDSKSIKVKTAQLIL 260
              ::.::.::|:.|||:||   ..|:|.   |..:|.:.|:|      |.|...::.|    |::
  Rat   227 LNSLILLVLMNNALTRLPDKPLCQHMPR---LHWLDFEGNRIHNLRNLTFISCNNLTV----LVM 284

  Fly   261 TNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNI 324
            ..|:|:::::.||.. .|:.:|.|..| |::.:.||.|..:.::::|::|...        :|.|
  Rat   285 RKNKINHLNEHAFTHLQKLDELDLGSN-KIENLPPNIFKDLKELSQLNISYNP--------IQKI 340

  Fly   325 EALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSD 389
            |.........||::.......|:|                         |||..
  Rat   341 EVNQFDYLAKLKSLLEGIEISNIQ-------------------------QRMFR----------- 369

  Fly   390 SGTRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDD 454
                                        ...:::.|.|..|.|
  Rat   370 ----------------------------PLINLSHIYFKKFQY---------------------- 384

  Fly   455 SSAELCGNFTFRKPNI-ECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRP 518
                 ||    ..|:: .|.|..:.::..|:::.....|:.||:|.|:...||:.|:.:...||.
  Rat   385 -----CG----YAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAITCFGNIFVICMRPYIRS 440

  Fly   519 ESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLS 583
            |:......:| .|..||..:|:||.::...|....|||...|..|...:.|:..|.|.|.::.:|
  Rat   441 ENKLHAMSIM-SLCCADCLMGVYLFVIGAFDLKFRGEYRKHAQPWMESVHCQFMGSLAVLSTEVS 504

  Fly   584 VFTLTVITIERWLAITQAMYLNHRIKLRP------AALIMLGGWIYSMLMSSLPL----FGISNY 638
            |..||.:|:|:::.|......     |||      |.||.:  ||...:::..||    |..:.|
  Rat   505 VLLLTFLTLEKYICIVYPFRC-----LRPRKCRTVAVLIFI--WITGFIVAFAPLGNKEFFKNYY 562

  Fly   639 SSTSICLPMENRDVYDT---IYLIAI-LGSNGVAFSIIAVCYAQIYLSLGRET---RQAHQNSPG 696
            .:..:|.|:.:.|...|   ||.:.| ||.|.|||.||...|..::.|:.:.|   .:..:....
  Rat   563 GTNGVCFPLHSEDTGSTGAQIYSVVIFLGINLVAFIIIVFSYGSMFYSVHQSTITATEIQKQVKK 627

  Fly   697 ELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINV----TKSKILLVFFYPLNSCADPYLYA 757
            |:.:||:...:|||:..||.||  |.|..|:   ||.|    |.:..:::|..|:||..:|.:|.
  Rat   628 EMILAKRFFFIVFTDALCWIPI--FILKFLS---LIRVEIPDTITSWVVIFILPINSALNPIIYT 687

  Fly   758 ILTSQYRQDLFTL 770
            :.|..:::.:..|
  Rat   688 LTTRPFKEMIHQL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	10/47 (21%)
		leucine-rich repeat	208..231	CDD:275380	8/25 (32%)
		leucine-rich repeat	233..256	CDD:275380	7/28 (25%)
		leucine-rich repeat	257..277	CDD:275380	5/20 (25%)
		LRR_8	258..313	CDD:290566	15/55 (27%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	2/19 (11%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		7tm_1	505..756	CDD:278431	82/271 (30%)
Rxfp1	XP_006232570.1	LDLa	33..68	CDD:238060	1/7 (14%)
		leucine-rich repeat	134..157	CDD:275380	5/22 (23%)
		LRR_RI	138..356	CDD:238064	57/246 (23%)
		LRR_8	158..216	CDD:290566	17/70 (24%)
		leucine-rich repeat	158..181	CDD:275380	7/34 (21%)
		leucine-rich repeat	182..205	CDD:275380	7/23 (30%)
		LRR_8	205..265	CDD:290566	14/62 (23%)
		leucine-rich repeat	206..229	CDD:275380	3/22 (14%)
		leucine-rich repeat	230..254	CDD:275380	7/23 (30%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		LRR_8	278..337	CDD:290566	16/71 (23%)
		leucine-rich repeat	279..302	CDD:275380	6/26 (23%)
		leucine-rich repeat	303..326	CDD:275380	7/23 (30%)
		leucine-rich repeat	327..350	CDD:275380	5/30 (17%)
		leucine-rich repeat	351..371	CDD:275380	7/83 (8%)
		7tm_1	427..686	CDD:278431	82/271 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810