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Protein Alignment Lgr1 and Lgr4

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_775450.2	Gene:	Lgr4 / 286994	RGDID:	628615	Length:	951	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	189/736 - (25%)
Similarity:	323/736 - (43%)	Gaps:	144/736 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PNLTAVSLAQSTDTPLTATMPRSAWKCCCWNAS---------NQAEEVECRCEGDGLNRVPQTLT 129
            |.|.|::||.:.    .:::|..|:.    |.|         |:.:.:...| .|||:.: :||.
  Rat   177 PTLQALTLALNN----ISSIPDFAFT----NLSSLVVLHLHNNKIKSLSQHC-FDGLDNL-ETLD 231

  Fly   130 LPIQRL---TIASAGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAP 191
            |....|   ..|...||.|:..|   :.|..:.|          |.||||....|||||::.:.|
  Rat   232 LNYNNLDEFPQAIKALPSLKELG---FHSNSISV----------IPDGAFGGNPLLRTIHLYDNP 283

  Fly   192 KLTFLSKDVFLGISD--------------------TVDI--IRIINSGLTRVPDLGHLPPHNILQ 234
             |:|:....|..:||                    ||.:  :.:..:.::.:|| .......:|:
  Rat   284 -LSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLESLTLTGTKISSIPD-DLCQNQKMLR 346

  Fly   235 MIDLDNNQITRIDSKSIKVKTAQLILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFD 298
            .:||..|.|..:.|.:......::.|..|:||.:.::.|.| :.:..|.|..| .::.:|..||.
  Rat   347 TLDLSYNNIRDLPSFNGCRALEEISLQRNQISLIKENTFQGLTSLRILDLSRN-LIREIHSGAFA 410

  Fly   299 GIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQF 363
            .:..||.||:|...|...|:.||..:..|.:.....||...:..:|.||:...:.:::.||||
  Rat   411 KLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKDALAARDFANLRSLSVPYAYQCCAF-- 473

  Fly   364 PSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFA 428
                              |  .|.|       .:.|:...|.|::...  ..:..|||...:|..
  Rat   474 ------------------W--GCDS-------YANLNTEDNSPQEHSV--TKEKGATDAANVTST 509

  Fly   429 SFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRI 493
            :          :...|.:||                     |.|.|......|||.::|...:|:
  Rat   510 A----------ENEEHSQII---------------------IHCTPSTGAFKPCEYLLGSWMIRL 543

  Fly   494 SVWIVVALAVVGN-VAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYF 557
            :||.:..:|::.| :.:|||..|.  .|.|..:..:..::.::|.:|:|..::..:||.|.|.:.
  Rat   544 TVWFIFLVALLFNLLVILTVFASC--SSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFA 606

  Fly   558 NFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAM---YLNHRIKLRPAALIMLG 619
            .|...|:.|.||||||.|.||:|..:||.||:..:||.:.....|   ..:|..:.:.|||:.|.
  Rat   607 EFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDLMKHGKSSHLRQFQVAALLALL 671

  Fly   620 GWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGVAFSIIAVCYAQIYLSLG 684
            |   :.:....|||....||::.:|||....:.....:.:.::..|.:||.::|:.|.::|.:|.
  Rat   672 G---AAVAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLE 733

  Fly   685 RETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFG----LTALAGYPLINVTKSKILLVFFY 745
            :|....:..|    ||.|.:|.|:|||...:.|:|||.    :||::..|  .:.||..|:  |:
  Rat   734 KEDLSENSQS----SVIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISP--EIMKSVTLI--FF 790

  Fly   746 PLNSCADPYLYAILTSQYRQD 766
            ||.:|.:|.||.....::::|
  Rat   791 PLPACLNPVLYVFFNPKFKED 811

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.