DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Lhcgr

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_037110.1	Gene:	Lhcgr / 25477	RGDID:	3007	Length:	700	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	275/736 - (37%)
Similarity:	395/736 - (53%)	Gaps:	120/736 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 CRCEGDGLNRVPQTLTLPIQRLTIASAGLPRLRHTGL--KVYGS---------TLLDVAFTDCLQ 167
            |.|..||..|.|.           ..|||.||..|.|  ||..|         ..::::.:|  .
  Rat    38 CDCAPDGALRCPG-----------PRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSD--S 89

  Fly   168 LELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRIINSGLTRVPDLGHLPPHNI 232
            ||.|:..||.||..|..:.|.|...|.::....|..: ..:..:.|.|:|:..:||:..:.....
  Rat    90 LERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNL-PRLKYLSICNTGIRTLPDVTKISSSEF 153

  Fly   233 LQMIDL-DNNQITRI--------DSKSIKVKTAQLILTNNEISYVDDSAFFGSKIAKLSLKENKK 288
            ..:::: ||..||.|        :::|:.:|     |..|....|...||.|:.:..|.||||..
  Rat   154 NFILEICDNLHITTIPGNAFQGMNNESVTLK-----LYGNGFEEVQSHAFNGTTLISLELKENIY 213

  Fly   289 LQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLT 353
            |:.||..||.|....:.||:|||.|..|||.||::|:.|...::::|||:||...|.:|..|.||
  Rat   214 LEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLT 278

  Fly   354 HSFHCCAFQFPSRHDPQRHAQRMLEI-EKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDD 417
            :..|||||    |:.|::.......| |.:.|||  :|..||    .||
  Rat   279 YPSHCCAF----RNLPKKEQNFSFSIFENFSKQC--ESTVRK----ADN---------------- 317

  Fly   418 SATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCG---NFTFRKP-NIECYPMPND 478
                              :|:....|.|.           ||.|   ::.|..| .::|.|.|:.
  Rat   318 ------------------ETLYSAIFEEN-----------ELSGWDYDYGFCSPKTLQCAPEPDA 353

  Fly   479 LNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLL 543
            .|||||:|||.:||:.:|::..||:.||:.||.|:|:.|.:.| |||||||:|:|||.|:|||||
  Rat   354 FNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLT-VPRFLMCNLSFADFCMGLYLL 417

  Fly   544 LVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRI 608
            |:|.:|:.:.|:|:|.|.|||.|.||..|||.|||||.|||:||||||:|||..||.|:.|:.::
  Rat   418 LIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKL 482

  Fly   609 KLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGVAFSIIA 673
            :||.|..||||||::|.|::::||.|||||...||||||:.......:|:::||..|.|||.:|.
  Rat   483 RLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVIC 547

  Fly   674 VCYAQIYLSLGRETRQAHQNSPG-ELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKS 737
            .||.:||.::    :.....:|. :..:|||||:|:||:|.|.:||:||.::|....|||.||.|
  Rat   548 ACYIRIYFAV----QNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNS 608

  Fly   738 KILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSALKYKDSLSGQATTRFTIHGS- 801
            |||||.|||:||||:|:||||.|..:::|...|||:.|.|::.|..|:       ...|:.:.|
  Rat   609 KILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYR-------RKEFSAYTSN 666

  Fly   802 -------IQRHSSLTCKMQTV 815
                   ..:.|..|.|:.||
  Rat   667 CKNGFPGASKPSQATLKLSTV 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	5/24 (21%)
		leucine-rich repeat	208..231	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..256	CDD:275380	7/31 (23%)
		leucine-rich repeat	257..277	CDD:275380	6/19 (32%)
		LRR_8	258..313	CDD:290566	22/54 (41%)
		leucine-rich repeat	278..302	CDD:275380	11/23 (48%)
		leucine-rich repeat	303..323	CDD:275380	11/19 (58%)
		leucine-rich repeat	324..346	CDD:275380	8/21 (38%)
		7tm_1	505..756	CDD:278431	133/251 (53%)
Lhcgr	NP_037110.1	leucine-rich repeat	55..78	CDD:275380	8/22 (36%)
		LRR_5	66..204	CDD:404228	34/145 (23%)
		leucine-rich repeat	79..103	CDD:275380	8/25 (32%)
		leucine-rich repeat	104..128	CDD:275380	5/24 (21%)
		LRR 1	126..150		5/24 (21%)
		leucine-rich repeat	129..150	CDD:275380	5/20 (25%)
		LRR 2	152..175		5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		LRR 3	176..200		7/28 (25%)
		leucine-rich repeat	179..202	CDD:275380	8/27 (30%)
		LRR 4	202..224		10/21 (48%)
		leucine-rich repeat	203..227	CDD:275380	11/23 (48%)
		LRR 5	225..248		11/22 (50%)
		leucine-rich repeat	228..248	CDD:275380	11/19 (58%)
		LRR 6	250..271		7/20 (35%)
		7tmA_LHCGR	365..638	CDD:320481	143/277 (52%)
		TM helix 1	366..390	CDD:320481	10/23 (43%)
		TM helix 2	399..420	CDD:320481	16/20 (80%)
		TM helix 3	444..466	CDD:320481	16/21 (76%)
		TM helix 4	489..505	CDD:320481	8/15 (53%)
		TM helix 5	529..552	CDD:320481	10/22 (45%)
		TM helix 6	572..594	CDD:320481	14/21 (67%)
		TM helix 7	606..631	CDD:320481	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352068
Domainoid	1	1.000	276	1.000	Domainoid score	I1672
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37276
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1676
OMA	1	1.010	-	-		QHG51461
OrthoDB	1	1.010	-	-		D136124at33208
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		otm44742
orthoMCL	1	0.900	-	-		OOG6_104064
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770