DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Fshr

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_954707.1	Gene:	Fshr / 25449	RGDID:	2632	Length:	692	Species:	Rattus norvegicus

Alignment Length:	714	Identity:	251/714 - (35%)
Similarity:	381/714 - (53%)	Gaps:	85/714 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 WKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAGLPRLRHTGLKVYGS-TLLDVA 161
            |.|.|   ||:.    ..|:...:..:|..|......|......|..:.......:|. ..::::
  Rat    21 WLCHC---SNRV----FLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEIS 78

  Fly   162 FTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRIINSGLTRVPDLGH 226
            ..|.  ||:|:...|:||..|..|.|..|..|.:::.:.|..: .::..:.|.|:|:.      |
  Rat    79 QNDV--LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNL-PSLRYLLISNTGIK------H 134

  Fly   227 LPP-HNI--LQ--MIDLDNN----QITRIDSKSIKVKTAQLILTNNEISYVDDSAFFGSKIAKLS 282
            ||. |.|  ||  ::|:.:|    .:.|.....:..::..|.|:.|.|..:.:.||.|:::.:|:
  Rat   135 LPAVHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELN 199

  Fly   283 LKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNL 347
            |.:|..|:.:..:.|.|......||:|.|.:..||:.||:|::.|..::|:.||.:|::..|..|
  Rat   200 LSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTL 264

  Fly   348 QRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTL----DNPFNMPED 408
            ..|.||:..|||||           |....:|.:....| :.|..|::...:    |...::.:|
  Rat   265 MEASLTYPSHCCAF-----------ANLKRQISELHPIC-NKSILRQDIDDMTQIGDQRVSLIDD 317

  Fly   409 FGSFG-GTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNIEC 472
            ..|:| |:|        :.:..|||                         :||....    ::.|
  Rat   318 EPSYGKGSD--------MMYNEFDY-------------------------DLCNEVV----DVTC 345

  Fly   473 YPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLC 537
            .|.|:..|||||:|||..||:.:|.:..||:.||..||.|:.:.:.:.| |||||||:|||||||
  Rat   346 SPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLT-VPRFLMCNLAFADLC 409

  Fly   538 LGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAM 602
            :|:||||:|.:|.|:..:|.|:|.|||.|.||..|||.|||||.|||:|||.||:|||..||.||
  Rat   410 IGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAM 474

  Fly   603 YLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGV 667
            .|..:::||.||.:|:.||.::...:..|:||||:|...||||||:.......:|::|:|..|.:
  Rat   475 QLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVL 539

  Fly   668 AFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLI 732
            ||.:|..||..|||::...|   ..:|..:..:||:||.|:||:|.|.:||:||.::|....|||
  Rat   540 AFVVICGCYTHIYLTVRNPT---IVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLI 601

  Fly   733 NVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSALKYKDSLSGQATTRF 796
            .|:|:|||||.|||:||||:|:||||.|..:|:|.|.||||.|..:..|..|:...| .||..|
  Rat   602 TVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETS-SATHNF 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	6/24 (25%)
		leucine-rich repeat	208..231	CDD:275380	6/23 (26%)
		leucine-rich repeat	233..256	CDD:275380	5/28 (18%)
		leucine-rich repeat	257..277	CDD:275380	7/19 (37%)
		LRR_8	258..313	CDD:290566	17/54 (31%)
		leucine-rich repeat	278..302	CDD:275380	6/23 (26%)
		leucine-rich repeat	303..323	CDD:275380	8/19 (42%)
		leucine-rich repeat	324..346	CDD:275380	6/21 (29%)
		7tm_1	505..756	CDD:278431	126/250 (50%)
Fshr	NP_954707.1	LRRNT	23..50	CDD:214470	7/33 (21%)
		LRR 1	49..72		3/22 (14%)
		LRR_8	72..132	CDD:290566	15/62 (24%)
		leucine-rich repeat	72..96	CDD:275380	7/25 (28%)
		LRR 2	73..97		7/25 (28%)
		leucine-rich repeat	97..121	CDD:275380	6/24 (25%)
		LRR 3	98..118		5/19 (26%)
		LRR 4	119..143		8/30 (27%)
		leucine-rich repeat	122..143	CDD:275380	8/26 (31%)
		leucine-rich repeat	144..171	CDD:275380	5/26 (19%)
		LRR 5	144..169		5/24 (21%)
		LRR 6	170..192		6/21 (29%)
		leucine-rich repeat	172..194	CDD:275380	7/21 (33%)
		LRR_8	193..245	CDD:290566	15/51 (29%)
		LRR 7	193..216		5/22 (23%)
		leucine-rich repeat	195..219	CDD:275380	6/23 (26%)
		LRR 8	217..240		8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		LRR 9	241..259		5/17 (29%)
		GnHR_trans	282..348	CDD:289164	16/103 (16%)
		7tm_1	378..625	CDD:278431	126/250 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352066
Domainoid	1	1.000	276	1.000	Domainoid score	I1672
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1676
OMA	1	1.010	-	-		QHG51461
OrthoDB	1	1.010	-	-		D136124at33208
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		otm44742
orthoMCL	1	0.900	-	-		OOG6_104064
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810