DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Tshr

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_037020.2	Gene:	Tshr / 25360	RGDID:	3911	Length:	764	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	280/755 - (37%)
Similarity:	413/755 - (54%)	Gaps:	101/755 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLAQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGD------GLNRVP------QTL---- 128
            ||.|.|   |...:|||.|...|     .:...||..|.|      .|:|:|      |||
  Rat     5 SLLQLT---LLLALPRSLWGRGC-----TSPPCECHQEDDFRVTCKELHRIPSLPPSTQTLKLIE 61

  Fly   129 ----TLPIQRLTIASAGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITN 189
                |:|    ::|.:.||.:.    ::|    |.:..|    |:.::..:|.||:.:..|.|.|
  Rat    62 THLKTIP----SLAFSSLPNIS----RIY----LSIDAT----LQRLEPHSFYNLSKMTHIEIRN 110

  Fly   190 APKLTFLSKDV--------FLGISDTVDIIRIINSGLTRVPDLGHLPPHNILQMIDL-DNNQITR 245
            ...||::..|.        |||         |.|:||...|||..:...::..:::: ||..:|.
  Rat   111 TRSLTYIDPDALTELPLLKFLG---------IFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTS 166

  Fly   246 IDSKSIK---VKTAQLILTNNEISYVDDSAFFGSKIAKLSLKENKKLQMMHPNAFDGIID-ITEL 306
            :...:.:   .:|..|.|.||..:.:...||.|:|:..:.|.:||.|..:..:||.|:.. .|.|
  Rat   167 VPENAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDKDAFGGVYSGPTLL 231

  Fly   307 DLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQR 371
            |:||||:..|||.||::::.|..:||.|||.:|...:|.:|.||.|::..|||||:      .|:
  Rat   232 DVSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFK------NQK 290

  Fly   372 HAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFG----SFGGTDDSATDITPIT---FAS 429
            ..:.:||.....:....:...||..:.:..|.....:.|    ..|...:|.....|..   :..
  Rat   291 KIRGILESLMCNESSIRNLRQRKSVNVMRGPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVF 355

  Fly   430 FDYMADDTMNKGTFHEKIILNPGDDS--------SAELCGNFTFRKPNIECYPMPNDLNPCEDVM 486
            |:...|:.:..|    :.:.||.:::        ...:||:    ..::.|.|..::.|||||:|
  Rat   356 FEEQEDEIIGFG----QELKNPQEETLQAFDSHYDYTVCGD----NEDMVCTPKSDEFNPCEDIM 412

  Fly   487 GYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAH 551
            ||::|||.||.|..:|::|||.||.|:|:...:.| |||||||:|||||.|:|:||||:|.:|.:
  Rat   413 GYKFLRIVVWFVSLMALLGNVFVLFVLLTSHYKLT-VPRFLMCNLAFADFCMGVYLLLIASVDLY 476

  Fly   552 SMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALI 616
            :..||:|.|.|||.|.||..|||.|||||.|||:||||||:|||.|||.||.|:.:|:||.|..|
  Rat   477 THTEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTI 541

  Fly   617 MLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGVAFSIIAVCYAQIYL 681
            |.|||:...|::.||:.|||:|:..||||||:........|:..:|..|.|||.|:..||.:||:
  Rat   542 MAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDTPLALAYIALVLLLNVVAFVIVCSCYVKIYI 606

  Fly   682 SLGRETRQAHQN-SPGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKILLVFFY 745
            ::    |....| ...:..:||:||:|:||:|.|.:||:|:.|:||...|||.||.||||||.||
  Rat   607 TV----RNPQYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFY 667

  Fly   746 PLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSALKYK 785
            ||||||:|:||||.|..:::|:|.||||.|||:..|..|:
  Rat   668 PLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQ 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	9/32 (28%)
		leucine-rich repeat	208..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..256	CDD:275380	3/26 (12%)
		leucine-rich repeat	257..277	CDD:275380	7/19 (37%)
		LRR_8	258..313	CDD:290566	21/55 (38%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	12/19 (63%)
		leucine-rich repeat	324..346	CDD:275380	8/21 (38%)
		7tm_1	505..756	CDD:278431	134/251 (53%)
Tshr	NP_037020.2	leucine-rich repeat	54..77	CDD:275380	7/26 (27%)
		LRR_5	65..221	CDD:404228	44/180 (24%)
		leucine-rich repeat	78..102	CDD:275380	7/35 (20%)
		LRR 1	100..124		7/23 (30%)
		leucine-rich repeat	103..127	CDD:275380	6/23 (26%)
		LRR 2	125..150		10/33 (30%)
		leucine-rich repeat	128..177	CDD:275380	13/57 (23%)
		LRR 3	151..174		3/22 (14%)
		LRR 4	176..199		7/22 (32%)
		leucine-rich repeat	180..201	CDD:275380	7/20 (35%)
		LRR 5	201..223		7/21 (33%)
		leucine-rich repeat	202..229	CDD:275380	7/26 (27%)
		LRR 6	225..248		12/22 (55%)
		leucine-rich repeat	230..251	CDD:275380	11/20 (55%)
		LRR 7	264..288		11/29 (38%)
		7tmA_TSH-R	415..689	CDD:320630	146/278 (53%)
		TM helix 1	417..441	CDD:320630	13/23 (57%)
		TM helix 2	450..471	CDD:320630	16/20 (80%)
		TM helix 3	495..517	CDD:320630	16/21 (76%)
		TM helix 4	540..556	CDD:320630	6/15 (40%)
		TM helix 5	580..603	CDD:320630	9/22 (41%)
		TM helix 6	623..645	CDD:320630	12/21 (57%)
		TM helix 7	657..682	CDD:320630	20/24 (83%)
		PDZ-binding	762..764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352067
Domainoid	1	1.000	276	1.000	Domainoid score	I1672
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1676
OMA	1	1.010	-	-		QHG51461
OrthoDB	1	1.010	-	-		D136124at33208
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		otm44742
orthoMCL	1	0.900	-	-		OOG6_104064
Panther	1	1.100	-	-	LDO	PTHR24372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770