DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and FSHR

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:XP_011531035.1 Gene:FSHR / 2492 HGNCID:3969 Length:729 Species:Homo sapiens


Alignment Length:778 Identity:257/778 - (33%)
Similarity:395/778 - (50%) Gaps:157/778 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 CRCEGDGLNRVPQTLTLPIQRLTIASAGLPR----LRH--TGLKV--------YGS-TLLDVAFT 163
            |.|.    |||   ......::|...:.|||    ||.  |.|:|        :|. ..::::..
Human    23 CHCS----NRV---FLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQN 80

  Fly   164 DCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRIINSGLTRVPDLGHLP 228
            |.  ||:|:...|:||..|..|.|..|..|.:::.:.|..:.: :..:.|.|:|:..:||:..: 
Human    81 DV--LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPN-LQYLLISNTGIKHLPDVHKI- 141

  Fly   229 PHNILQ-MIDL-DNNQITRIDSKS---IKVKTAQLILTNNEISYVDDSAFFGSKIAKLSLKENKK 288
             |::.: ::|: ||..|..|:..|   :..::..|.|..|.|..:.:.||.|:::.:|:|.:|..
Human   142 -HSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNN 205

  Fly   289 LQMM----------------------HPNAF-------DGIIDITE-----LDLSSTSLVGLPSA 319
            |:.:                      .||..       .|:::..|     :|:|.|.:..|||.
Human   206 LEELPNDVFHGASGPVILNRRTRTPTEPNVLLAKYPSGQGVLEEPESLSSSIDISRTRIHSLPSY 270

  Fly   320 GLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRK 384
            ||:|::.|..::|:.||.:|::.....|..|.||:..|||||                  ..||:
Human   271 GLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF------------------ANWRR 317

  Fly   385 Q-------CKSD---------SGTRKERSTL--DNPFNMPEDFGSFGGTDDSATDITPITFASFD 431
            |       |...         :..|.:||:|  ||..:....|              .:|:..||
Human   318 QISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGF--------------DMTYTEFD 368

  Fly   432 YMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVW 496
            |                         :||....    ::.|.|.|:..|||||:|||..||:.:|
Human   369 Y-------------------------DLCNEVV----DVTCSPKPDAFNPCEDIMGYNILRVLIW 404

  Fly   497 IVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAY 561
            .:..||:.||:.|| |||:.......|||||||:|||||||:|:||||:|.:|.|:..:|.|:|.
Human   405 FISILAITGNIIVL-VILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAI 468

  Fly   562 DWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSML 626
            |||.|.||..|||.|||||.|||:|||.||:|||..||.||.|:.:::||.||.:|:.|||::..
Human   469 DWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFA 533

  Fly   627 MSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAH 691
            .:..|:||||:|...||||||:.......:|::::|..|.:||.:|..||..|||::    |..:
Human   534 AALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTV----RNPN 594

  Fly   692 -QNSPGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYL 755
             .:|..:..:||:||:|:||:|.|.:||:||.::|....|||.|:|:|||||.|:|:||||:|:|
Human   595 IVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFL 659

  Fly   756 YAILTSQYRQDLFTLLSKLGLCQQSALKYKDSLSGQATTRFTIHGSIQRHSSLTCKMQTVMGA 818
            |||.|..:|:|.|.||||.|..:..|..|:...|.      |:|.:..|:...:...:...|:
Human   660 YAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS------TVHNTHPRNGHCSSAPRVTSGS 716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 57/230 (25%)
leucine-rich repeat 182..207 CDD:275380 6/24 (25%)
leucine-rich repeat 208..231 CDD:275380 5/22 (23%)
leucine-rich repeat 233..256 CDD:275380 6/27 (22%)
leucine-rich repeat 257..277 CDD:275380 7/19 (37%)
leucine-rich repeat 278..302 CDD:275380 7/52 (13%)
leucine-rich repeat 303..323 CDD:275380 9/24 (38%)
leucine-rich repeat 324..346 CDD:275380 5/21 (24%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 137/277 (49%)
TM helix 1 490..516 CDD:320264 12/25 (48%)
TM helix 2 524..549 CDD:320264 19/24 (79%)
TM helix 3 569..599 CDD:320264 20/29 (69%)
TM helix 4 611..633 CDD:320264 8/21 (38%)
TM helix 5 653..682 CDD:320264 10/28 (36%)
TM helix 6 692..725 CDD:320264 14/32 (44%)
TM helix 7 735..760 CDD:320264 17/24 (71%)
FSHRXP_011531035.1 LRRNT 20..45 CDD:396168 6/28 (21%)
LRR 42..>298 CDD:443914 63/260 (24%)
leucine-rich repeat 72..96 CDD:275380 7/25 (28%)
leucine-rich repeat 97..121 CDD:275380 6/23 (26%)
leucine-rich repeat 122..143 CDD:275380 5/22 (23%)
leucine-rich repeat 144..172 CDD:275380 6/27 (22%)
leucine-rich repeat 173..194 CDD:275380 7/20 (35%)
leucine-rich repeat 195..216 CDD:275380 4/20 (20%)
leucine-rich repeat 220..246 CDD:275380 2/25 (8%)
leucine-rich repeat 247..277 CDD:275380 10/29 (34%)
GnHR_trans 316..383 CDD:432511 17/109 (16%)
7tmA_FSH-R 397..671 CDD:320482 137/278 (49%)
TM helix 1 398..424 CDD:320482 12/26 (46%)
TM helix 2 431..456 CDD:320482 19/24 (79%)
TM helix 3 476..506 CDD:320482 20/29 (69%)
TM helix 4 518..540 CDD:320482 8/21 (38%)
TM helix 5 560..589 CDD:320482 10/28 (36%)
TM helix 6 599..629 CDD:320482 13/29 (45%)
TM helix 7 639..664 CDD:320482 17/24 (71%)

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