DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Tshr

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_035778.3	Gene:	Tshr / 22095	MGIID:	98849	Length:	764	Species:	Mus musculus

Alignment Length:	766	Identity:	280/766 - (36%)
Similarity:	424/766 - (55%)	Gaps:	107/766 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 ECRCEGD------GLNRVP------QTL--------TLPIQRLTIASAGLPRLRHTGLKVYGSTL 157
            ||..|.|      .|:|:|      |||        |:|    ::|.:.||.:.    ::|
Mouse    30 ECHQEDDFRVTCKELHRIPSLPPSTQTLKLIETHLKTIP----SLAFSSLPNIS----RIY---- 82

  Fly   158 LDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDV--------FLGISDTVDIIRII 214
            |.:..|    |:.::..:|.||:.:..|.|.|...||::..|.        |||         |.
Mouse    83 LSIDAT----LQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLG---------IF 134

  Fly   215 NSGLTRVPDLGHLPPHNILQMIDL-DNNQITRIDSKSIK---VKTAQLILTNNEISYVDDSAFFG 275
            |:||...|||..:...:|..:::: ||..:|.:...:.:   .:|..|.|.||..:.|...||.|
Mouse   135 NTGLRIFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAFNG 199

  Fly   276 SKIAKLSLKENKKLQMMHPNAFDGIID-ITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIP 339
            :|:..:.|.:||.|..:..:||.|:.. .|.||:||||:..|||.||::::.|..::|.|||.:|
Mouse   200 TKLDAVYLNKNKYLTAIDNDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLP 264

  Fly   340 SIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPF- 403
            ...:|.:|.||.|::..|||||:      .|:..:.:||.....:....:...||..:.|..|.
Mouse   265 LSLSFLHLTRADLSYPSHCCAFK------NQKKIRGILESLMCNESSIRNLRQRKSVNILRGPIY 323

  Fly   404 -NMPEDFG--SFGGTDDSATDITPIT---FASFDYMADDTMNKGTFHEKIILNPGDDS------- 455
             ...||.|  |.|...:|....:|..   :..|:...|:.:..|    :.:.||.:::
Mouse   324 QEYEEDPGDNSVGYKQNSKFQESPSNSHYYVFFEEQEDEVVGFG----QELKNPQEETLQAFESH 384

  Fly   456 -SAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPE 519
             ...:||:    ..::.|.|..::.|||||:|||::|||.||.|..||::||:.||.::|:...:
Mouse   385 YDYTVCGD----NEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYK 445

  Fly   520 STPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSV 584
            .| |||||||:|||||.|:|:||||:|.:|.::..||:|.|.|||.|.||..|||.|||||.|||
Mouse   446 LT-VPRFLMCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSV 509

  Fly   585 FTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMEN 649
            :||||||:|||.|||.||.|:.:|:||.|..||.|||:...|::.||:.|||:|:..||||||:.
Mouse   510 YTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDT 574

  Fly   650 RDVYDTIYLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQN-SPGELSVAKKMALLVFTNFA 713
            .......|::.:|..|.|||.::..||.:||:::    |....| ...:..:||:||:|:||:|.
Mouse   575 DTPLALAYIVLVLLLNVVAFVVVCSCYVKIYITV----RNPQYNPRDKDTKIAKRMAVLIFTDFM 635

  Fly   714 CWSPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQ 778
            |.:||:|:.|:||...|||.||.||||||.||||||||:|:||||.|..:::|:|.||||.|:|:
Mouse   636 CMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICK 700

  Fly   779 QSALKYKDSLSGQATTRFTIHGSIQRHSSLTCKMQTVMGAETQKMLKNSED 829
            :.|..|:    ||         .:..::|...::|.: ..:|::.|.|.:|
Mouse   701 RQAQAYQ----GQ---------RVCPNNSTGIQIQKI-PQDTRQSLPNMQD 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	9/32 (28%)
		leucine-rich repeat	208..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..256	CDD:275380	3/26 (12%)
		leucine-rich repeat	257..277	CDD:275380	8/19 (42%)
		LRR_8	258..313	CDD:290566	22/55 (40%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	12/19 (63%)
		leucine-rich repeat	324..346	CDD:275380	7/21 (33%)
		7tm_1	505..756	CDD:278431	131/251 (52%)
Tshr	NP_035778.3	leucine-rich repeat	54..77	CDD:275380	7/26 (27%)
		LRR_5	65..221	CDD:290045	46/180 (26%)
		leucine-rich repeat	78..102	CDD:275380	7/35 (20%)
		LRR 1	100..124		7/23 (30%)
		leucine-rich repeat	103..127	CDD:275380	6/23 (26%)
		LRR 2	125..150		10/33 (30%)
		leucine-rich repeat	128..152	CDD:275380	10/32 (31%)
		LRR 3	151..174		4/22 (18%)
		leucine-rich repeat	153..177	CDD:275380	3/23 (13%)
		LRR 4	176..199		8/22 (36%)
		leucine-rich repeat	181..201	CDD:275380	8/19 (42%)
		LRR 5	200..223		7/22 (32%)
		leucine-rich repeat	202..226	CDD:275380	7/23 (30%)
		LRR 6	225..248		12/22 (55%)
		LRR 7	264..288		11/29 (38%)
		7tm_4	423..>556	CDD:304433	75/133 (56%)
		7tm_1	431..678	CDD:278431	131/251 (52%)
		PDZ-binding	762..764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848470
Domainoid	1	1.000	279	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1693
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51461
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		otm42677
orthoMCL	1	0.900	-	-		OOG6_104064
Panther	1	1.100	-	-	LDO	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760