DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr1 and fshr

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001001812.1	Gene:	fshr / 195820	ZFINID:	ZDB-GENE-020423-5	Length:	668	Species:	Danio rerio

Alignment Length:	726	Identity:	257/726 - (35%)
Similarity:	383/726 - (52%)	Gaps:	110/726 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLAQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGL----NRVPQTLTLPIQRLTIAS- 139
            |:|.:.||       .:|.:.|.:|.|.::    ..|.|:.:    .|:|...|....:||..|
Zfish    14 SMANTEDT-------LAASQFCAFNGSTRS----FVCLGNKVLEIPRRIPTNTTFVEIKLTQISV 67

  Fly   140 ---AGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVF 201
               |.|..|..         |..:..::...||.|:..||.|||.|..|.||.:..|. :.||.|
Zfish    68 FRRAALSELHE---------LKRIVVSENGALERIEALAFFNLTELEEITITKSKNLV-MHKDAF 122

  Fly   202 LGISDTVDIIRIINSGLTRVPDLGHLPPHNILQMIDL-DNNQITRIDSKSI----KVKTAQLILT 261
            ..: ..:..:.|.|:||..:||...:....:..:.|| ||..|.||.|.:.    .....:|.||
Zfish   123 WRL-PKLRYLTISNTGLKILPDFSKINSAALEFLFDLQDNMHIERIPSNAFLGLTNATITELRLT 186

  Fly   262 NNEISYVDDSAFFGSKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEA 326
            .|.|..:|..||.|:||.||.|..|::|..:|..||.|......||:|.|::..||.:.|:.::.
Zfish   187 KNGIREIDSHAFNGTKIGKLFLMGNQQLNHIHSYAFKGAEGPVVLDISRTAVHTLPESMLKTLKL 251

  Fly   327 LYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSG 391
            |...:.::|:.:||:..|..|.:|.||:..|||||:...:|            :..:.|..:.:|
Zfish   252 LMAVSVYSLRKLPSLELFTELTQANLTYPSHCCAFKNFKKH------------KSVKNQMCNVTG 304

  Fly   392 TRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSS 456
            ..:|          |:.|..|   :|...|:..:|
Zfish   305 AHEE----------PDFFNFF---NDHCKDVIEVT------------------------------ 326

  Fly   457 AELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPEST 521
                           |||.|:..|||||:||:.:||:.:|.:..||:|||..||.|:|:.|.:.|
Zfish   327 ---------------CYPTPDAFNPCEDIMGFTFLRVLIWFISVLAIVGNTVVLLVLLTSRYKLT 376

  Fly   522 PVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFT 586
             |||||||||||||||:|:||||:|.:|.|:...|:|:..|||.|.||.||||.|||:|.|||:|
Zfish   377 -VPRFLMCHLAFADLCMGIYLLLIAAVDIHTQSRYYNYGIDWQTGAGCHVAGFFTVFSSELSVYT 440

  Fly   587 LTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRD 651
            ||.||:|||..||.||.|..:::||.|.|:|..||::|:|.:.:|:||:|:||.|||||||:...
Zfish   441 LTAITLERWHTITYAMQLERQMRLRHACLVMATGWLFSLLAALMPMFGVSSYSKTSICLPMDVET 505

  Fly   652 VYDTIYLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWS 716
            :....|::.:|..|..||.::.|||..|||::   ...|...:..::.:||:||:|:||:|.|.:
Zfish   506 LLSQGYVVLLLLLNAAAFLVVCVCYTLIYLTV---RNPAFVPANADMRIAKRMAVLIFTDFLCMA 567

  Fly   717 PIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSA 781
            ||:||.::|....|||..:.:|:|||.|||:|||::|:|||..|..:::|.|.|.|:.|..::.|
Zfish   568 PISFFAISAAFKLPLITASHAKVLLVLFYPINSCSNPFLYAFFTKTFKRDFFILTSRFGCFKRRA 632

  Fly   782 LKYKDSL-SGQ 791
            ..|...: |||
Zfish   633 HIYCTEISSGQ 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	8/24 (33%)
		leucine-rich repeat	208..231	CDD:275380	6/22 (27%)
		leucine-rich repeat	233..256	CDD:275380	8/27 (30%)
		leucine-rich repeat	257..277	CDD:275380	9/19 (47%)
		LRR_8	258..313	CDD:290566	24/54 (44%)
		leucine-rich repeat	278..302	CDD:275380	10/23 (43%)
		leucine-rich repeat	303..323	CDD:275380	7/19 (37%)
		leucine-rich repeat	324..346	CDD:275380	5/21 (24%)
		7tm_1	505..756	CDD:278431	125/250 (50%)
fshr	NP_001001812.1	leucine-rich repeat	79..103	CDD:275380	8/23 (35%)
		LRR_5	93..224	CDD:290045	47/132 (36%)
		leucine-rich repeat	104..127	CDD:275380	8/24 (33%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		leucine-rich repeat	152..177	CDD:275380	8/24 (33%)
		leucine-rich repeat	180..202	CDD:275380	9/21 (43%)
		leucine-rich repeat	203..227	CDD:275380	10/23 (43%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..274	CDD:275380	6/21 (29%)
		7tm_1	360..607	CDD:278431	125/250 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593958
Domainoid	1	1.000	86	1.000	Domainoid score	I8068
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1681
OMA	1	1.010	-	-		QHG51461
OrthoDB	1	1.010	-	-		D136124at33208
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		otm25228
orthoMCL	1	0.900	-	-		OOG6_104064
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770