DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr1 and fshr-1

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001263853.1	Gene:	fshr-1 / 179381	WormBaseID:	WBGene00008239	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	715	Identity:	224/715 - (31%)
Similarity:	364/715 - (50%)	Gaps:	74/715 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AVSLAQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAGL 142
            |:|||| |.....|........|.| ..:.:..:.||.|.|..::::|..||        |..|.
Worm    33 ALSLAQ-TKHSCMALKAEDGEGCTC-KQTKRYGQPECCCMGLIVSQLPTNLT--------ADVGY 87

  Fly   143 PRLRHTGLKVYGSTLLD-------VAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDV 200
            ..|.:|.:.|......|       :...:...||.|...:.:.|:.||.:.:...|.|..:|..:
Worm    88 LYLHNTSISVITPNFFDKFPSIRELEIDNSAHLEHIDGSSLSVLSKLRKLSVVKCPNLREISGKL 152

  Fly   201 FLGISDTVDIIRIINSGLTRVPDLGHLPPHNI-LQMIDLDNNQITRI-DSKSIKVKTAQLILTNN 263
            .:..:...::| :.|:||..:|.|.....|:: |..|||..|:|..| |||...||...::|:.|
Worm   153 LVNNTRIQNVI-LKNNGLATMPSLRMTDAHHVLLDRIDLSGNKIKFISDSKVRNVKARTVVLSEN 216

  Fly   264 EISYVDDSAFFGSKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALY 328
            ::..:...||..|:..||.|..|..|:.:..:||..:..:..||||.||:..||..||:.::.|.
Worm   217 KLIEISGYAFTESQFLKLKLNNNPDLRSLSVDAFKNMAGLQTLDLSHTSIDTLPINGLKKLKTLI 281

  Fly   329 IQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQF---PSRHDPQRHAQRMLEIEK----WRKQC 386
            :.:..|||::||:.:|.:|:.|:.|:..|||.|::   .:.:|..::.:...||.|    .|:|.
Worm   282 LNDVPTLKSLPSVLSFTDLETAHFTYPHHCCLFKYVDDVTMNDNGKYQRNAKEIHKRICDKREQQ 346

  Fly   387 KSDSGTRKERST-----LDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEK 446
            |  ...|::|.|     ||.......|..::.|.||:..|..|
Worm   347 K--VARRRKRETSGIDFLDMLLKEWTDNSTYTGPDDADDDELP---------------------- 387

  Fly   447 IILNPGDDSSAELCGNF--TFRK--PNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNV 507
                |..:..||.|.:.  ..:|  .||.|||.|:.|||||:::||.:|||:||:|...|:|||:
Worm   388 ----PFVEIGAEPCQSIGEEVQKYYSNITCYPQPDALNPCENIVGYPFLRIAVWVVCLAAIVGNI 448

  Fly   508 AVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVA 572
            .|..::..:..:...:....|.:::.||:..|:||.::|..||....||:..|..||.|.||:.|
Worm   449 IVWALLGIVYEKRMRMHYLYMINMSVADMVTGIYLAVLAIADAKMSDEYYRHAVWWQTGWGCRAA 513

  Fly   573 GFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISN 637
            |||.||||.|.:.::.:|..|.... |:..:...|:..:...|:|:|||:::::|:.||.|.:|:
Worm   514 GFLAVFASELGIISMFLIAFEMSYN-TRQSFRGRRLSPKVGVLLMIGGWLFAIIMAILPWFDVSS 577

  Fly   638 YSSTSICLPMENRDVYDTIYLIAILGSNGVAFSIIAVCYAQIYLSL-GRETRQAHQNSPGELSVA 701
            ||.:|:|||:....::|..|||..|..|.:||:.:|:.|..|...| ..|||:.      :.::.
Worm   578 YSESSVCLPLRAATIFDKSYLIFGLSFNFLAFAAMALSYGFIVKMLKENETREE------DRALI 636

  Fly   702 KKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTS--QYR 764
            .||.:||.|:..||.|..|||.||..|:||::::.:|.:||||:|:|:.|:|:||...|.  |:|
Worm   637 TKMTVLVVTDLICWFPTLFFGFTATIGFPLLSLSSAKFVLVFFFPINAFANPFLYVFFTEVIQHR 701

Fly 765 764
Worm 702 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	5/24 (21%)
		leucine-rich repeat	208..231	CDD:275380	6/22 (27%)
		leucine-rich repeat	233..256	CDD:275380	12/23 (52%)
		leucine-rich repeat	257..277	CDD:275380	4/19 (21%)
		LRR_8	258..313	CDD:290566	17/54 (31%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	10/19 (53%)
		leucine-rich repeat	324..346	CDD:275380	7/21 (33%)
		7tm_1	505..756	CDD:278431	89/251 (35%)
fshr-1	NP_001263853.1	leucine-rich repeat	87..108	CDD:275380	4/20 (20%)
		LRR	<97..>293	CDD:227223	56/196 (29%)
		leucine-rich repeat	109..133	CDD:275380	4/23 (17%)
		leucine-rich repeat	134..158	CDD:275380	5/23 (22%)
		leucine-rich repeat	159..174	CDD:275380	4/15 (27%)
		leucine-rich repeat	185..208	CDD:275380	11/22 (50%)
		leucine-rich repeat	209..231	CDD:275380	5/21 (24%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		leucine-rich repeat	256..276	CDD:275380	10/19 (53%)
		7tmA_Glyco_hormone_R	430..702	CDD:320264	102/279 (37%)
		TM helix 1	432..456	CDD:320264	11/23 (48%)
		TM helix 2	466..487	CDD:320264	6/20 (30%)
		TM helix 3	511..533	CDD:320264	10/21 (48%)
		TM helix 4	555..571	CDD:320264	6/15 (40%)
		TM helix 5	595..618	CDD:320264	9/22 (41%)
		TM helix 6	633..658	CDD:320264	10/24 (42%)
		TM helix 7	670..695	CDD:320264	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167668
Domainoid	1	1.000	178	1.000	Domainoid score	I2123
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37276
Inparanoid	1	1.050	330	1.000	Inparanoid score	I1437
Isobase	1	0.950	-	0	Normalized mean entropy	S5552
OMA	1	1.010	-	-		QHG51461
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		oto20618
orthoMCL	1	0.900	-	-		OOG6_104064
Panther	1	1.100	-	-	LDO	PTHR24372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3294
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.840