DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and Lgr5

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	840	Identity:	204/840 - (24%)
Similarity:	358/840 - (42%)	Gaps:	172/840 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LHHL-----LLTSLSGRHFVYATSAVGGALSANNCHDIHHGFD-VYPNLTAVSLAQSTDTPLTAT 92
            |.||     .||.:..:.|...::.....|:.|.   |||..| .:.||:::.:...
Mouse   164 LRHLWLDDNALTDVPVQAFRSLSALQAMTLALNK---IHHIADYAFGNLSSLVVLHL-------- 217

  Fly    93 MPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRL---TIASAGLPRLRHTGLK--- 151
                        .:|:...:..:| .|||:.: :||.|....|   ..|...|..|:..|..
Mouse   218 ------------HNNRIHSLGKKC-FDGLHSL-ETLDLNYNNLDEFPTAIKTLSNLKELGFHSNN 268

  Fly   152 ---------VYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTI------YITNAPKLTFLSKDVF 201
                     |...:|:.:.|.| ..::.:...||.:|..|||:      :||..|.||..:
Mouse   269 IRSIPERAFVGNPSLITIHFYD-NPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTA---- 328

  Fly   202 LGISDTVDIIRIINSGLTRVPD--LGHLPPHNILQMIDLDNNQITRIDSKSIKVKTAQLILTNNE 264
                 |::.:.:..:.::.:|.  ...||.   ||::||..|.:..:.|.|...|..::.|.:||
Mouse   329 -----TLESLTLTGAKISSLPQAVCDQLPN---LQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNE 385

  Fly   265 ISYVDDSAF---FGSKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEA 326
            |..:..|.|   |  .:..|:|..| |:.::|||||..:..:.:|||||..|...|..||..:..
Mouse   386 IYEIKGSTFQQLF--NLRSLNLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTH 447

  Fly   327 LYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEI-EKWRKQCKSDS 390
            |.:.....|:::....||..|:...:..::.||||         ...:.:.:| .:|.|    |.
Mouse   448 LKLTGNRALQSLIPSANFPELKIIEMPSAYQCCAF---------GGCENVYKISNQWNK----DD 499

  Fly   391 GTRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDS 455
            |     :::|:...  :|.|.|...|:...:         |::.|...:....|
Mouse   500 G-----NSVDDLHK--KDAGLFQVQDERDLE---------DFLLDFEEDLKALH----------- 537

  Fly   456 SAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAV-LTVILSIRPE 519
                         :::|.|.|....|||.:.|...:||.||....||:..|..| |||.
Mouse   538 -------------SVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALVALTVF------ 583

  Fly   520 STPV----PRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFAS 580
            .||:    .:.|:..:|..|:.:|:...::|.:||.:.|.:......|:.|:||::.|||::|||
Mouse   584 RTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFLSIFAS 648

  Fly   581 HLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICL 645
            ..|:|.||:..:||..::..:.....:..|.....|:|...:.::.::::||.|.|.|:::.:||
Mouse   649 ESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAIVLLCVLLALTIATIPLLGGSKYNASPLCL 713

  Fly   646 PMENRDVYDTIYLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGEL------SVAKKM 704
            |:...:...|.|::|::..|.:.|.|:.:.|.::|.||.:          |||      |:.|.:
Mouse   714 PLPFGEPSTTGYMVALVLLNSLCFLIMTIAYTKLYCSLEK----------GELENLWDCSMVKHI 768

  Fly   705 ALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDL-- 767
            |||:|.|...:.|:||...::|.....|:....|.:|:...||.||.:|.||.:....:::|:
Mouse   769 ALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGS 833

  Fly   768 ------FTLLSK---LGLCQQSALKYKDSLSGQATTRFTIHGSIQRHSSLTCKMQTVMGA 818
                  |.:.||   |.......::.:...|.||...||       |:|:...:.:..||
Mouse   834 LGKHTRFWMRSKHASLLSINSDDVEKRSCESTQALVSFT-------HASIAYDLPSTSGA 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	8/30 (27%)
		leucine-rich repeat	208..231	CDD:275380	3/24 (13%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..277	CDD:275380	7/22 (32%)
		LRR_8	258..313	CDD:290566	21/57 (37%)
		leucine-rich repeat	278..302	CDD:275380	9/23 (39%)
		leucine-rich repeat	303..323	CDD:275380	9/19 (47%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		7tm_1	505..756	CDD:278431	74/261 (28%)
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470
		leucine-rich repeat	68..91	CDD:275380
		LRR_RI	88..386	CDD:238064	56/259 (22%)
		LRR_8	92..150	CDD:290566
		leucine-rich repeat	92..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..198	CDD:290566	8/36 (22%)
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		LRR_8	188..246	CDD:290566	16/82 (20%)
		leucine-rich repeat	188..211	CDD:275380	8/25 (32%)
		leucine-rich repeat	212..235	CDD:275380	5/43 (12%)
		leucine-rich repeat	236..258	CDD:275380	6/22 (27%)
		LRR_8	257..314	CDD:290566	12/57 (21%)
		leucine-rich repeat	259..282	CDD:275380	3/22 (14%)
		leucine-rich repeat	283..304	CDD:275380	5/21 (24%)
		LRR_8	352..410	CDD:290566	19/63 (30%)
		leucine-rich repeat	354..375	CDD:275378	7/20 (35%)
		leucine-rich repeat	376..389	CDD:275378	4/12 (33%)
		leucine-rich repeat	400..423	CDD:275378	9/23 (39%)
		leucine-rich repeat	445..467	CDD:275378	4/21 (19%)
		7tm_1	575..820	CDD:278431	74/260 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910