DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr1 and Rxfp2

DIOPT Version :10

Sequence 1:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster
Sequence 2:XP_011239323.1 Gene:Rxfp2 / 140498 MGIID:2153463 Length:740 Species:Mus musculus


Alignment Length:813 Identity:191/813 - (23%)
Similarity:314/813 - (38%) Gaps:222/813 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 KCLSFEFQCRLLLHHLLLTSLSGRHFVYATSAVGGALSANNCHDIHHGF-----DVYPNLTAVSL 81
            |||...|.|.                  .....|.....:||.|. .|:     .|:.|:..|:|
Mouse    43 KCLPRAFHCD------------------GVDDCGNGADEDNCGDT-SGWTTIFGTVHGNVNKVTL 88

  Fly    82 AQSTDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAGLPRLR 146
            .|..   ..:..|:   .|.|       .|.|..|....|..||:..:    .:|:.|....::.
Mouse    89 TQEC---FLSQYPQ---HCYC-------RENELECVKADLKAVPKVSS----NVTLLSLKKNKIH 136

  Fly   147 HTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDII 211
            ...:||                       |:..|.||.||:.: ..:|.:|:..|||:.: :.|:
Mouse   137 RLPVKV-----------------------FSRYTELRKIYLQH-NCITHISRRAFLGLHN-LQIL 176

  Fly   212 RIINSGLTRV-----PDLGHLPPHNILQMIDLDNNQITRIDSKSI-------------------- 251
            .:.::.:|.:     .||     |.:..:| ||:|.||||..||.                    
Mouse   177 YLSHNCITSLRPGIFKDL-----HQLAWLI-LDDNPITRISQKSFMGLNSLFFLSMVGNRLEALP 235

  Fly   252 KVKTAQL------ILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLS 309
            :...||:      .|.||.|.|:.:|.|.. ..:..|.|..| ::..:....|..:.::.|||||
Mouse   236 ETLCAQMPQLNWVDLANNGIKYITNSTFLTCDSLTVLFLPRN-QIGFVPEKTFSSLKNLGELDLS 299

  Fly   310 STSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQ 374
            |..:..||   :.....|::.....|.:.|.:|..:|               ||           
Mouse   300 SNMITKLP---VHLFSDLHLLQKLNLSSNPLLYVHKN---------------QF----------- 335

  Fly   375 RMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMN 439
                            |:.|:..:||.                ...:|..|:...|..|      
Mouse   336 ----------------GSLKQLQSLDL----------------ERIEIPNISTGMFQPM------ 362

  Fly   440 KGTFHEKIILNPGDDSSAELCGNFTFR----KPNIE-CYPMPNDLNPCEDVMGYQWLRISVWIVV 499
            |...|  |.|.             |||    .|::. |.|..:.::..||::....||:|||::.
Mouse   363 KNLSH--IYLK-------------TFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIA 412

  Fly   500 ALAVVGNVAVLTVILSIRPESTPVP---RFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAY 561
            .:..|||..|:.|...|:.|:|...   :.|.|    ||..:|:||..|...|....|:|..:|.
Mouse   413 FITCVGNFLVIAVRSLIKAENTTHAMSIKILCC----ADCLMGVYLFSVGVFDIKYRGQYQKYAL 473

  Fly   562 DWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSML 626
            .|...:.|::.|||...::.:||..||.:|:|::|.|. ..:.|.|:..|..|:.:...|:...|
Mouse   474 LWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIV-FPFSNLRLGKRQTAVALASIWVVGFL 537

  Fly   627 MSSLPL-----FGISNYSSTSICLPMENRDVYDTI-------YLIAI-LGSNGVAFSIIAVCYAQ 678
            ::::|.     || :.|....:|.|:.    ||..       |.:.| ||.|.:||.:|.:.|..
Mouse   538 IAAVPFTREDYFG-NFYGKNGVCFPLH----YDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVT 597

  Fly   679 IYLSLGR---ETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKIL 740
            ::.|:.:   :|.:...:...|::||.:...:||::..||.|:....:.:|....:.....|.| 
Mouse   598 MFCSIHKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWI- 661

  Fly   741 LVFFYPLNSCADPYLYAILTSQYRQDLFTLLSK 773
            :|||.|:||..:|.||.:.||.::..|..||.|
Mouse   662 VVFFLPVNSALNPILYTLTTSFFKDKLKQLLHK 694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 52/223 (23%)
leucine-rich repeat 182..207 CDD:275380 9/24 (38%)
leucine-rich repeat 208..231 CDD:275380 4/27 (15%)
leucine-rich repeat 233..256 CDD:275380 10/42 (24%)
leucine-rich repeat 257..277 CDD:275380 8/26 (31%)
leucine-rich repeat 278..302 CDD:275380 4/23 (17%)
leucine-rich repeat 303..323 CDD:275380 8/19 (42%)
leucine-rich repeat 324..346 CDD:275380 4/21 (19%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 85/295 (29%)
TM helix 1 490..516 CDD:320264 10/25 (40%)
TM helix 2 524..549 CDD:320264 8/27 (30%)
TM helix 3 569..599 CDD:320264 11/29 (38%)
TM helix 4 611..633 CDD:320264 5/26 (19%)
TM helix 5 653..682 CDD:320264 11/36 (31%)
TM helix 6 692..725 CDD:320264 8/32 (25%)
TM helix 7 735..760 CDD:320264 11/24 (46%)
Rxfp2XP_011239323.1 LDLa 31..66 CDD:238060 6/40 (15%)
LRR <123..>350 CDD:443914 62/323 (19%)
leucine-rich repeat 125..148 CDD:275380 5/45 (11%)
leucine-rich repeat 149..172 CDD:275380 9/23 (39%)
leucine-rich repeat 173..196 CDD:275380 4/27 (15%)
leucine-rich repeat 197..220 CDD:275380 10/23 (43%)
leucine-rich repeat 221..244 CDD:275380 2/22 (9%)
leucine-rich repeat 245..268 CDD:275380 7/22 (32%)
leucine-rich repeat 269..292 CDD:275380 4/23 (17%)
leucine-rich repeat 293..316 CDD:275380 9/25 (36%)
leucine-rich repeat 317..340 CDD:275380 7/64 (11%)
leucine-rich repeat 341..360 CDD:275380 4/34 (12%)
7tm_GPCRs 403..688 CDD:475119 85/295 (29%)
TM helix 1 404..428 CDD:410628 10/23 (43%)
TM helix 2 437..458 CDD:410628 7/24 (29%)
TM helix 3 482..504 CDD:410628 7/21 (33%)
TM helix 4 526..542 CDD:410628 2/15 (13%)
TM helix 5 574..597 CDD:410628 9/22 (41%)
TM helix 6 623..645 CDD:410628 6/21 (29%)
TM helix 7 656..681 CDD:410628 11/25 (44%)

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