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Protein Alignment Lgr1 and Lgr4

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_766259.2	Gene:	Lgr4 / 107515	MGIID:	1891468	Length:	951	Species:	Mus musculus

Alignment Length:	815	Identity:	204/815 - (25%)
Similarity:	344/815 - (42%)	Gaps:	170/815 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PNLTAVSLAQSTDTPLTATMPRSAWKCCCWNAS---------NQAEEVECRCEGDGLNRVPQTLT 129
            |.|.|::||.:.    .:::|..|:.    |.|         |:.:.:...| .|||:.: :||.
Mouse   177 PTLQALTLALNN----ISSIPDFAFT----NLSSLVVLHLHNNKIKSLSQHC-FDGLDNL-ETLD 231

  Fly   130 LPIQRL---TIASAGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAP 191
            |....|   ..|...||.|:..|   :.|..:.|          |.|||||...|||||::.:.|
Mouse   232 LNYNNLDEFPQAIKALPSLKELG---FHSNSISV----------IPDGAFAGNPLLRTIHLYDNP 283

  Fly   192 KLTFLSKDVFLGISD--------------------TVDI--IRIINSGLTRVPDLGHLPPHNILQ 234
             |:|:....|..:||                    ||.:  :.:..:.::.:|| .......:|:
Mouse   284 -LSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLAGTVHLESLTLTGTKISSIPD-DLCQNQKMLR 346

  Fly   235 MIDLDNNQITRIDSKSIKVKTAQLILTNNEISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFD 298
            .:||..|.|..:.|.:......::.|..|:||.:.::.|.| :.:..|.|..| .::.:|..||.
Mouse   347 TLDLSYNDIRDLPSFNGCRALEEISLQRNQISLIKETTFQGLTSLRILDLSRN-LIREIHSGAFA 410

  Fly   299 GIIDITELDLSSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQF 363
            .:..||.||:|...|...|:.||..:..|.:.....||...:..:|.||:...:.:::.||||
Mouse   411 KLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFQLKDALAARDFANLRSLSVPYAYQCCAF-- 473

  Fly   364 PSRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFA 428
                              |  .|.|       .:.|:...|.|:|...  ..:..|||....|..
Mouse   474 ------------------W--GCDS-------YANLNTEDNSPQDHSV--TKEKGATDAANATST 509

  Fly   429 SFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRI 493
            :          :...|.:||                     |.|.|......|||.::|...:|:
Mouse   510 A----------ESEEHSQII---------------------IHCTPSTGAFKPCEYLLGSWMIRL 543

  Fly   494 SVWIVVALAVVGN-VAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYF 557
            :||.:..:|::.| :.:|||..|.  .|.|..:..:..::.::|.:|:|..::..:||.|.|.:.
Mouse   544 TVWFIFLVALLFNLLVILTVFASC--SSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFA 606

  Fly   558 NFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAM---YLNHRIKLRPAALIMLG 619
            .|...|:.|.||||||.|.||:|..:||.||:..:||.:.....|   ..:|..:.:.|||:.|.
Mouse   607 EFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDVMKNGKSSHLRQFQVAALVALL 671

  Fly   620 GWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGVAFSIIAVCYAQIYLSLG 684
            |   :.:....|||....||::.:|||....:.....:.:.::..|.:||.::|:.|.::|.:|.
Mouse   672 G---AAIAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLE 733

  Fly   685 RETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFG----LTALAGYPLINVTKSKILLVFFY 745
            :|....:..|    |:.|.:|.|:|||...:.|:|||.    :||::..|  .:.||..|:  |:
Mouse   734 KEDPSENSQS----SMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISP--EIMKSVTLI--FF 790

  Fly   746 PLNSCADPYLYAILTSQYRQDLFTL--------------LSKLGLCQQSALKYK----DSLSGQA 792
            ||.:|.:|.||.....:::.|...|              :|..|.|.:....|.    ..|.|..
Mouse   791 PLPACLNPVLYVFFNPKFKDDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNL 855

  Fly   793 TT-----RFTIHGSIQ-RH--SSLTCKMQTVMGAE 819
            |.     .|.:...:. :|  .|.:|.:.||...:
Mouse   856 TVCDCCESFLLTKPVSCKHLIKSHSCPVLTVASCQ 890

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.