DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and rxfp1

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_031751332.1	Gene:	rxfp1 / 100494807	XenbaseID:	XB-GENE-985695	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	169/782 - (21%)
Similarity:	301/782 - (38%)	Gaps:	214/782 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GGALSANNCHDIHHG--------FDVYPNLTAVSLAQSTDTPLTATMPRSAWKCCCWNASNQAEE 111
            |.....:||.| ::|        |:.:.....:::......|...|:.....:|.|       ..
Frog    56 GNQADEDNCGD-NNGWSQQLDKLFEKHYEKIGLNVFDLEMKPSECTLGPVPTQCLC-------RG 112

  Fly   112 VECRCEGDGLNRV----PQTLTLPIQRLTIASAG------LPRLR-----HTGLK---------V 152
            :|..|:|..|..|    |....:.:|...:...|      .|.||     |..::         :
Frog   113 LELDCDGAKLRTVPSVSPNVTIMSLQNNMLRKLGPDEFRIFPDLRKLYLQHNNIRTVSVHAFKGL 177

  Fly   153 YGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRIINSG 217
            |..|.|.::..   ::..::.|.|.:|..|..:.|.| .|:|.:....|.|::..: ::.::|:.
Frog   178 YNLTKLYLSHN---EITTLKPGVFEDLHRLEWLIIEN-NKITRIYPQTFQGLNSLI-LLVMMNNF 237

  Fly   218 LTRVPDLG---HLPPHNILQMIDLDNNQI------TRIDSKSIKVKTAQLILTNNEISYVDDSAF 273
            |.|:||..   |:|.   |..:|.:.|.:      |.|...::.|    |::..|.||.:.::.|
Frog   238 LERLPDKSLCQHMPK---LNWLDFEGNNVQSLTNTTFISCATLTV----LVMRRNRISTISENTF 295

  Fly   274 FG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSL-----------VGLPSAGLQNIEA 326
            .. .::.:|.| .|.:::...|:...|:.::::|::|...:           :.|.|..|:.||
Frog   296 SSLYRLDELDL-ANNRIEAFSPSLMKGVKELSQLNISHNPIQKIQADQFDYVIKLKSLSLEGIE- 358

  Fly   327 LYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSG 391
                       ||      |:||                         ||.
Frog   359 -----------IP------NIQR-------------------------RMF-------------- 367

  Fly   392 TRKERSTLDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSS 456
                         ||            ..::|.|.|..|.|
Frog   368 -------------MP------------LKNLTHIYFKKFQY------------------------ 383

  Fly   457 AELCGNFTFRKPNI-ECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPES 520
               || |.   |:: .|.|..:.::..|:::.....|:.||:|..:...||:.|:.....||.|:
Frog   384 ---CG-FA---PHVRNCKPNTDGISSLENLLASIVQRVFVWVVSVITCFGNIFVICTRPYIRSEN 441

  Fly   521 TPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVF 585
            ......:| .|..||..:|:||.::...|....|||...|..|.....|::.|.|.:.::.:||.
Frog   442 KLHAMSIM-SLCCADCLMGVYLFVIGYFDLKYRGEYNENAQAWMDSTQCRLVGSLAILSTEVSVL 505

  Fly   586 TLTVITIERWLAITQAMYLNHRIKLRP------AALIMLGGWIYSMLMSSLPL----FGISNYSS 640
            .||.:|:|:::.|......     |:|      ..||::  ||...:::.:||    |..:.|.:
Frog   506 LLTYLTLEKYICIVYPFRC-----LKPGKCRTITTLILI--WIIGFVIAFIPLSNQTFFHNYYGT 563

  Fly   641 TSICLPMENRDVYDT---IY-LIAILGSNGVAFSIIAVCYAQIYLSLGRETRQA---HQNSPGEL 698
            ..:|.|:.:.....|   || :|..||.|..||.||...|:.::.|:.|....|   |.:...|:
Frog   564 NGVCFPLHSEQPESTAAQIYSVIIFLGVNLAAFIIIVFSYSSMFYSIHRTAIMATEIHNHIKKEM 628

  Fly   699 SVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQY 763
            ::||:...:|||:..||.||....|.:|....:.....|.: ::|..|:||..:|.||.|.|..:
Frog   629 TLAKRFFFIVFTDALCWIPIFILKLLSLLQVEIPGSISSWV-VIFILPINSALNPILYTITTRPF 692

  Fly   764 RQ 765
            ::
Frog   693 KE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	7/24 (29%)
		leucine-rich repeat	208..231	CDD:275380	7/25 (28%)
		leucine-rich repeat	233..256	CDD:275380	6/28 (21%)
		leucine-rich repeat	257..277	CDD:275380	5/20 (25%)
		LRR_8	258..313	CDD:290566	12/55 (22%)
		leucine-rich repeat	278..302	CDD:275380	5/23 (22%)
		leucine-rich repeat	303..323	CDD:275380	5/30 (17%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		7tm_1	505..756	CDD:278431	75/267 (28%)
rxfp1	XP_031751332.1	LDLa	29..64	CDD:238060	1/7 (14%)
		LRRNT	105..134	CDD:214470	8/35 (23%)
		PPP1R42	131..375	CDD:411060	58/338 (17%)
		leucine-rich repeat	132..155	CDD:275380	2/22 (9%)
		leucine-rich repeat	156..179	CDD:275380	3/22 (14%)
		leucine-rich repeat	180..203	CDD:275380	5/25 (20%)
		leucine-rich repeat	204..227	CDD:275380	7/23 (30%)
		leucine-rich repeat	228..252	CDD:275380	6/24 (25%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	6/26 (23%)
		leucine-rich repeat	301..324	CDD:275380	5/23 (22%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		leucine-rich repeat	349..370	CDD:275380	14/102 (14%)
		7tmA_RXFP1_LGR7	410..696	CDD:320631	83/294 (28%)
		TM helix 1	412..436	CDD:320631	7/23 (30%)
		TM helix 2	445..466	CDD:320631	7/21 (33%)
		TM helix 3	490..512	CDD:320631	6/21 (29%)
		TM helix 4	534..550	CDD:320631	4/17 (24%)
		TM helix 5	582..605	CDD:320631	11/22 (50%)
		TM helix 6	631..653	CDD:320631	9/21 (43%)
		TM helix 7	664..689	CDD:320631	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910