DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and tshr

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_017951898.2	Gene:	tshr / 100492843	XenbaseID:	XB-GENE-991483	Length:	731	Species:	Xenopus tropicalis

Alignment Length:	744	Identity:	266/744 - (35%)
Similarity:	411/744 - (55%)	Gaps:	97/744 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 LNRVPQT--LTLPIQRLTIASAGLPRLRHTGLKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLR 183
            :.|:.:|  .|:|:.    |...||.:.:    :|.|  ||.|      |:.::.|:|..|..:.
Frog    29 IRRLEETHLQTIPVD----AFLNLPNISN----IYIS--LDTA------LQKLEAGSFRRLHRVA 77

  Fly   184 TIYITNAPKLTFLSKDVFLGISDTVDIIRIINSGLTRVPDLGHLPPHNILQMIDL-DNNQITRID 247
            .|.|.|...|.::..|.|..: .::..:.|:|:||:..|||..:...::..:::: ||..|..:.
Frog    78 HIEIRNVKNLMYIDPDAFQDL-PSLKYLGILNTGLSLFPDLTKIHSTSMTVIVEIADNPHIASVP 141

  Fly   248 S---KSIKVKTAQLILTNNEISYVDDSAFFGSKIAKLSLKENKKLQMMHPNAFDGIIDITE-LDL 308
            :   :.:..:...|.|.||..:::....|.|:|:.::.|.:|..|..:|...|.|.|.... ||:
Frog   142 ANGFQGLGKEFLTLKLYNNGFTHLQGHIFNGTKLDEVYLHKNNLLGGLHEELFLGAISGPNLLDM 206

  Fly   309 SSTSLVGLPSAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHA 373
            |.|::..||:.||:|::.|..|:|.|||.:|.|..|.:|::|.|::..||||||
Frog   207 SQTAITSLPTKGLENLKHLLAQSTWTLKKLPPIKTFAHLRKAELSYPSHCCAFQ----------- 260

  Fly   374 QRMLEIEKWRKQCKSDSGTRKERSTLDN------------PFNMPEDFGSFGGTDDSATDITPIT 426
                   .|.|:..........:|||.:            |:.  :|:  ..|..|...:...|.
Frog   261 -------NWTKKKSYLESVICNQSTLHSLIKKRSLGLFVGPYY--QDY--IEGDSDQTENSKVID 314

  Fly   427 FAS-------FDYMADDTMNKGTFHEKIILNPGDDSSA-------ELCGNFTFRKPNIECYPMPN 477
            |.|       |:...::.:.   |.::|....|:::.|       .:||.    ...:||.|.|:
Frog   315 FHSNNHYSVFFEEQGEEEVG---FGQEIKNAQGENTPAFENHYEIIICGG----SEELECTPEPD 372

  Fly   478 DLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLMCHLAFADLCLGLYL 542
            :.|||||:|||.:|||.||.|..||::|||.||.::::...:.| |||||||:|||||.|:|:||
Frog   373 EFNPCEDIMGYNFLRIVVWFVNLLAILGNVFVLFILITSHYKLT-VPRFLMCNLAFADFCMGIYL 436

  Fly   543 LLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIERWLAITQAMYLNHR 607
            ||:|.:|.|:..||:|:|.:||.|.||..|||.|||||.|||:|||:||:|||.|||.||.|:.:
Frog   437 LLIASVDVHTRSEYYNYAINWQTGPGCNAAGFFTVFASELSVYTLTMITLERWYAITFAMRLDRK 501

  Fly   608 IKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTIYLIAILGSNGVAFSII 672
            |:||.|:.||||||.....::.|||.|||:|...||||||:........|::.:|..|.:||.||
Frog   502 IRLRHASFIMLGGWTLCFFLALLPLVGISSYIKVSICLPMDTEAALSQAYIVFVLMLNIIAFIII 566

  Fly   673 AVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFGLTALAGYPLINVTKS 737
            ..||.:||:::   ....:::...:..:||:||:|:||:|.|.:||:|:.|:|:...|||.|:.|
Frog   567 CACYIKIYITV---RNPQYKSGDKDTKIAKRMAILIFTDFICMAPISFYALSAIMNKPLITVSNS 628

  Fly   738 KILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKLGLCQQSALKYKDSLSGQATTRFTIHGSI 802
            |||||.||||||||:|:||||.|..:|:|:|.||||.|:|:..|..|:    ||..:
Frog   629 KILLVLFYPLNSCANPFLYAIFTKAFRRDVFILLSKFGICEHQAQVYR----GQTVS-------- 681

  Fly   803 QRHSSLTCKMQTVMGAETQKMLKNSEDYV 831
            .::||.:|..:...|  |.:.|.|..|::
Frog   682 AKNSSGSCCQRESGG--TGQTLANMADFI 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	6/24 (25%)
		leucine-rich repeat	208..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..256	CDD:275380	3/26 (12%)
		leucine-rich repeat	257..277	CDD:275380	6/19 (32%)
		LRR_8	258..313	CDD:290566	18/55 (33%)
		leucine-rich repeat	278..302	CDD:275380	6/23 (26%)
		leucine-rich repeat	303..323	CDD:275380	8/20 (40%)
		leucine-rich repeat	324..346	CDD:275380	9/21 (43%)
		7tm_1	505..756	CDD:278431	128/250 (51%)
tshr	XP_017951898.2	leucine-rich repeat	31..50	CDD:275380	6/22 (27%)
		LRR_8	49..106	CDD:404697	16/69 (23%)
		leucine-rich repeat	51..75	CDD:275380	9/35 (26%)
		leucine-rich repeat	76..100	CDD:275380	6/24 (25%)
		leucine-rich repeat	101..119	CDD:275380	7/17 (41%)
		leucine-rich repeat	120..150	CDD:275380	3/29 (10%)
		leucine-rich repeat	152..174	CDD:275380	6/21 (29%)
		leucine-rich repeat	175..202	CDD:275380	7/26 (27%)
		7tmA_TSH-R	384..658	CDD:320630	142/277 (51%)
		TM helix 1	386..410	CDD:320630	13/23 (57%)
		TM helix 2	419..440	CDD:320630	16/20 (80%)
		TM helix 3	464..486	CDD:320630	15/21 (71%)
		TM helix 4	509..525	CDD:320630	6/15 (40%)
		TM helix 5	549..572	CDD:320630	9/22 (41%)
		TM helix 6	592..614	CDD:320630	12/21 (57%)
		TM helix 7	626..651	CDD:320630	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1764
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1740
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D136124at33208
OrthoFinder	1	1.000	-	-		FOG0001622
OrthoInspector	1	1.000	-	-		otm47778
Panther	1	1.100	-	-	LDO	PTHR24372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1188
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160