DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr1 and lgr6

DIOPT Version :9

Sequence 1:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_017209265.2	Gene:	lgr6 / 100330212	-ID:	-	Length:	962	Species:	Danio rerio

Alignment Length:	914	Identity:	197/914 - (21%)
Similarity:	368/914 - (40%)	Gaps:	228/914 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LHHLLLTSLSGRHF----------VYATSAVGGALSANNCHDIHHGFDVY--PNLTAVSLAQSTD 86
            ||.|....|||.|.          :|....:   :..||..:.....|.:  |||.::.|    |
Zfish    83 LHFLSELRLSGNHLRHIPGPMLQGLYNLKVL---MLQNNQLERLPSEDPWELPNLLSLRL----D 140

  Fly    87 TPLTATMP----------RSAWKCCCWNASNQAEEVECRCEGDGLNRVP----------QTLTLP 131
            ..|...:|          |..|                 .:.:.|..:|          |.:||.
Zfish   141 ANLIMEVPARTLSGMRSLRHLW-----------------LDDNALTEIPVSALNDLSSLQAMTLA 188

  Fly   132 IQRLT---------IASAGLPRLRHTGLKVYGST---------LLDVAFTDCLQ----------- 167
            :.|:|         :::..:..|.:..::..|..         .|::.|.|..:
Zfish   189 LNRITLIPDYAFRNLSNLVVLHLHNNMIRTLGQNCFEGLHSLETLELNFNDLQEFPVAIRTLAKL 253

  Fly   168 ---------LELIQDGAFANLTLLRTIYITNAPKLTFLSKDVF---------------------- 201
                     ::.|.:.||....||:||:....| :.|:.:..|
Zfish   254 QELGFHNNNIKAIPERAFVGNPLLQTIHFYENP-IQFVGRSAFQFLPKLHTLSLNGATEIREFPD 317

  Fly   202 LGISDTVDIIRIINSGLTRVP-DLGHLPPHNILQMIDLDNNQITRIDSKSIKVKTAQLILTNNEI 265
            |..:.::.::.:..:|||.:| ||.||.|.  |::::|.:|.|..:.|........::.|.:|.|
Zfish   318 LKGTTSLQVLTLTRAGLTSLPYDLCHLLPK--LKVLELSHNVIEELPSFYHCTSLQEIGLQHNLI 380

  Fly   266 SYVDDSAF--FGSKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEALY 328
            ..::.:.|  .|| :..|.|..| .:..:||:||..:..:.:|||:...|..||..||.::..|.
Zfish   381 KQIEMNTFQQLGS-LRSLDLSWN-SINSIHPDAFFSLQSLIKLDLTGNRLSNLPMTGLTSLTHLK 443

  Fly   329 IQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGTR 393
            ::....|.....:.:|.|::...:.:::.||.|...|.:   |.|      .:|.:|..|:.
Zfish   444 LKGNMALSRSFGLEDFPNIRVIEMPYAYQCCVFGGCSSY---RSA------SQWEEQMGSEE--- 496

  Fly   394 KERSTLDNPFNMPEDFGSFGGTDDSATDITPI-TFASFDYMADDTMNKGTFHEKIILNPGDDSSA 457
                         |||      ...:..:.|| |..::|.                    |....
Zfish   497 -------------EDF------QKKSPSLFPIHTDNNYDL--------------------DLEEF 522

  Fly   458 ELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGN-VAVLTVILSIRPEST 521
            :|....:..:.:|:|.|:|....||:::.....:|:.:|::..::::|| :.:|||..|  |...
Zfish   523 QLAIEESKLQTSIQCTPIPGPFKPCDNLFDSWVVRLGMWLISLVSLMGNSLLILTVFTS--PSYL 585

  Fly   522 PVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFT 586
            ...:|::..::.|:|..||....:|.:||.:.||:......|:.|.||:..|||:|.||..|:..
Zfish   586 SPVKFIIGTISGANLLTGLCTGTLALVDARTFGEFALHGAQWEMGAGCRAVGFLSVLASEGSILF 650

  Fly   587 LTVITIERWLAITQAMYLNHRIKL---RPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPME 648
            ||:..::..::::.|........|   |.||:..|.   .|:.:::|||.|:..|.:|.:|:|..
Zfish   651 LTLAAVQCSVSVSCARAYGKSPSLGSVRAAAVACLA---LSLAVAALPLIGVGEYGATPLCMPSP 712

  Fly   649 NRDVYDTI--YLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTN 711
            ..|...:.  :::|::..|.:.|.:|...|.::|..|    .:...:|..:.::.|.:|.|:|||
Zfish   713 LPDGEPSTLGFMVALIMMNSLCFLVITGTYIKLYWDL----MKGDFDSIWDCAMIKHVAWLIFTN 773

  Fly   712 FACWSPIAFFGLTALAG-YPLI-NVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTLLSKL 774
            ...:.|:||...::|.. :|:. .|.||.:|::.  ||.:..:|.||.:....:|:|:..|||:.
Zfish   774 CLLYCPVAFLTFSSLLSLFPVSEEVVKSVVLVLL--PLPASINPLLYLLFNPHFREDMRLLLSRA 836

  Fly   775 GL--------------------CQQSALKYKDSLSG----------QATTRFTIHGSIQRHSSLT 809
            .|                    ..|:.:.:.....|          :...|||...|:   :.:.
Zfish   837 HLNHDRNLDSFVSVDTEKSSYDSTQALVSFATEADGVFESLSVPNPETVARFTCPPSV---ALIP 898

  Fly   810 CKMQ 813
            |:||
Zfish   899 CQMQ 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	7/46 (15%)
		leucine-rich repeat	208..231	CDD:275380	9/23 (39%)
		leucine-rich repeat	233..256	CDD:275380	5/22 (23%)
		leucine-rich repeat	257..277	CDD:275380	5/21 (24%)
		LRR_8	258..313	CDD:290566	16/56 (29%)
		leucine-rich repeat	278..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..323	CDD:275380	8/19 (42%)
		leucine-rich repeat	324..346	CDD:275380	3/21 (14%)
		7tm_1	505..756	CDD:278431	72/258 (28%)
lgr6	XP_017209265.2	LRRNT	28..64	CDD:214470
		PLN00113	53..>448	CDD:331614	79/393 (20%)
		leucine-rich repeat	62..85	CDD:275380	1/1 (100%)
		leucine-rich repeat	86..109	CDD:275380	5/22 (23%)
		leucine-rich repeat	110..133	CDD:275380	3/25 (12%)
		leucine-rich repeat	134..157	CDD:275380	5/26 (19%)
		leucine-rich repeat	158..181	CDD:275380	4/39 (10%)
		leucine-rich repeat	182..205	CDD:275380	5/22 (23%)
		leucine-rich repeat	206..229	CDD:275380	2/22 (9%)
		leucine-rich repeat	230..252	CDD:275380	3/21 (14%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..298	CDD:275380	6/21 (29%)
		leucine-rich repeat	324..338	CDD:275378	3/13 (23%)
		leucine-rich repeat	348..369	CDD:275380	5/20 (25%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..438	CDD:275380	8/19 (42%)
		7tmA_LGR6	554..829	CDD:320484	77/285 (27%)
		TM helix 1	555..581	CDD:320484	7/25 (28%)
		TM helix 2	588..613	CDD:320484	6/24 (25%)
		TM helix 3	633..663	CDD:320484	10/29 (34%)
		TM helix 4	675..697	CDD:320484	7/24 (29%)
		TM helix 5	719..748	CDD:320484	6/28 (21%)
		TM helix 6	757..787	CDD:320484	9/29 (31%)
		TM helix 7	797..822	CDD:320484	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010