DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and Lpo

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_536345.2	Gene:	Lpo / 76113	MGIID:	1923363	Length:	710	Species:	Mus musculus

Alignment Length:	721	Identity:	211/721 - (29%)
Similarity:	330/721 - (45%)	Gaps:	127/721 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 TAKDD-LHN------------FAISNSAIEQVMTTQLFGKKE-------------------QV-- 201
            ||:.| :|:            |..|...::..|||::...:.                   ||
Mouse    28 TAETDIIHDTVEEVKVWVNKAFLDSRDRLKMAMTTKIHSTRHLSDYLKHAKGRTRTAIRSGQVWE 92

  Fly   202 ----PVEDFITNNVPIKFTETPLAHH--CQPPP---VCGNIRSVYRSMDGTCNNPEPQRSLWGAA 257
                .:..|:||........|.|:..  |.||.   .| ||.|.||::.|.|||  .:....|:|
Mouse    93 ESLKKLSQFLTNVTGQGLDLTLLSWEAGCDPPAPTMTC-NISSPYRTITGYCNN--RKNPALGSA 154

  Fly   258 GQPMERMLPPAYEDGI-----WTPRAHSSDGTPLLGARKISRTL---LSDVDRPHPKYNLMVMQF 314
            .:.:.|.||..||||:     ||| ....:|.||...|::|..:   |::.|....|.:::.||:
Mouse   155 NRALARWLPAEYEDGLSLPYGWTP-GKMRNGFPLPQPREVSNQIAAYLNEEDVLDQKRSMLFMQW 218

  Fly   315 GQVLAHDI--SQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFA----CMPIHVEPDDEFFSAFGV 373
            ||::.||:  :..:.:..:..:..||            ..|..    |.||...|.|......|
Mouse   219 GQIVDHDMDFAPETEMGSDTYTKAQC------------DEHCIQGDNCFPIMFPPGDPKLKTQG- 270

  Fly   374 RCLNFVRLSLV-PSPDCQLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAFRG--GRLRM---MN 432
            :|:.|.|...| |:|..:....:|:..:|.|:|||.||......:..||....  |.:.:   ::
Mouse   271 KCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASLVYSPEPSLANRLRNLSSPLGLMAVNEEVS 335

  Fly   433 DFGRDLLPLTNDKKACPSE----EAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELN 493
            |.||...|... .|..|.|    .||..||.:||.|.::.|.|.|...|..|||||:|..|..||
Mouse   336 DNGRPFPPFVK-MKPSPCEVINATAGVPCFLAGDSRASEQILLATSHTLFIREHNRLATELSRLN 399

  Fly   494 PSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNE 558
            |....|||:||||:|:.|.:|..|:.::|||::|.:..|   .:|.:||    ||.:|:|.|:|.
Mouse   400 PHWDRETLYQEARKIMGAFIQITTFRDYLPILLGDEMQK---WIPPYQG----YNESVDPRISNV 457

  Fly   559 FSGAAYRMGHSSVDGKFQIRQEHGRIDE---------VVNIPDVMFNPSRMRKREFYDDMLRTLY 614
            |: .|.|.||      .:|.....|:||         .:.:..|.||..|:.|....|.::|.|.
Mouse   458 FT-FALRFGH------LEIPSTVYRLDENYQPWGSESELPLHTVFFNTWRLVKDGGIDPLVRGLL 515

  Fly   615 SQ--PMQQVDSSISQGLSRFLFRGDNPF-GLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFE 676
            ::  .:...:..::..|...||:.::.. |.|||:|||||.||.|...||.:....|..:..:.|
Mouse   516 AKNAKLMHQNKMMTGELRNKLFQPNHTIHGFDLASINIQRSRDHGQPGYNSWRAFCGLSQPKTLE 580

  Fly   677 QFPI-----EIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYY 736
            :...     .:|:||..:|.||.:||:|:|.:.|..|..|.||.....::..||.|.:.|||:::
Mouse   581 ELSAVMKNEVLAKKLMDLYGTPSNIDIWLGAVAEPLVHRGRVGPLLTCLLGQQFQRIRDGDRFWW 645

  Fly   737 EYDNGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPS 801
            |     |||.|...|.:.::|::.:||:|||:.   :..|||..|....:| :..:.|.  ::..
Mouse   646 E-----NPGVFTEKQRESLQKMSFSRLVCDNTG---IDKVPLNPFQANAYP-HGFVDCS--SIDK 699

  Fly   802 VNLEAW 807
            ::|..|
Mouse   700 LDLSPW 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337
		An_peroxidase	237..772	CDD:281139	180/575 (31%)
		peroxinectin_like	396..767	CDD:188655	131/396 (33%)
Lpo	NP_536345.2	myeloperoxidase_like	281..692	CDD:188656	141/434 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810