DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and TPO

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_024308853.1	Gene:	TPO / 7173	HGNCID:	12015	Length:	947	Species:	Homo sapiens

Alignment Length:	760	Identity:	236/760 - (31%)
Similarity:	368/760 - (48%)	Gaps:	131/760 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PKERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPV-RRGFPDFAHGLVFHSTAKDDLHNFAISN 183
            |:|.|..       :||:|::|..:..|:...|..: :||....|..|.|....:..  :..|:.
Human    46 PEESRVS-------SVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPT--SGVIAR 101

  Fly   184 SAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLA-----HHCQP---PPVCGN--IRSVYR 238
            :|  ::|.|.:...|.:|.::...:.:.....:|..|:     ..|.|   ||.|.|  :.:.||
Human   102 AA--EIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYR 164

  Fly   239 SMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSS----DGTPLLGARKISRTLL-- 297
            .:.|.|||.:..|  |||:...:.|.|||.||||...||..:.    :|.||...|:::|.::
Human   165 PITGACNNRDHPR--WGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQV 227

  Fly   298 -SDVDRPHPKYNLMVMQFGQVLAHDISQT--SSIRLEDGSLVQC---CSPEGKVALSPQQSHFAC 356
             ::|.....:|:.::|.:||.:.|||:.|  |:.:...|....|   |           ::...|
Human   228 SNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTC-----------ENQNPC 281

  Fly   357 MPIHVEPDDEFFSAFGVRCLNFVRLSLV-PSPDCQLSYG--------KQLTKVTHFVDASPVYGS 412
            .||.:  .:|...|.|..||.|.|.|.. .:.|....:|        :|:..:|.|:|||.||||
Human   282 FPIQL--PEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGS 344

  Fly   413 SDEASRSLRAFRG--GRLRM---MNDFGRDLLPLTNDK--KAC------PSEEAGKSCFHSGDGR 464
            |....|.||.:..  |.||:   :.|.||..||....:  .||      |.|..| .||.:||||
Human   345 SPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRG-PCFLAGDGR 408

  Fly   465 TNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQ 529
            .:::.||..|..|..|||||:|.||..||...|.:.::||||::|.|..|.||..:::|.|:||:
Human   409 ASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPE 473

  Fly   530 QMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSV-------DGKFQIRQEHGRIDEV 587
            ..:::  |..::|    |:...||.::|.||.||:|.||:::       |..|   |||
Human   474 AFQQY--VGPYEG----YDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASF---QEH------ 523

  Fly   588 VNIPDV--------MFNPSRMRKREFYDDMLRTLYSQP--MQQVDSSISQGLSRFLFRGDNPFGL 642
               ||:        .|:|..:.:....|.::|.|.::|  :|..|..:::.|:..||...|...|
Human   524 ---PDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTL 585

  Fly   643 DLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIE---------IAQKLSRVYRTPDDIDL 698
            |||:||:|||||.||..||::.|..|.|:|.:    |.:         :|.|:..:|:.||:||:
Human   586 DLASINLQRGRDHGLPGYNEWREFCGLPRLET----PADLSTAIASRSVADKILDLYKHPDNIDV 646

  Fly   699 WVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARL 763
            |:|||.|..:.....|..||.:|..|....:.||.:::|     |...|...|.:|:.|.:|:|:
Human   647 WLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWE-----NSHVFTDAQRRELEKHSLSRV 706

  Fly   764 LCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAWR 808
            :|||:.   |..||:.||.....| .....||  ::..:||||||
Human   707 ICDNTG---LTRVPMDAFQVGKFP-EDFESCD--SITGMNLEAWR 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337
		An_peroxidase	237..772	CDD:281139	194/594 (33%)
		peroxinectin_like	396..767	CDD:188655	141/409 (34%)
TPO	XP_024308853.1	thyroid_peroxidase	179..746	CDD:188657	200/614 (33%)
TPO	XP_024308853.1	CCP	754..807	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820