Protein Alignment Pxt and PTGS1

DIOPT Version :9

• Sequence 1: NP_650648.3
• Gene: Pxt / 42131
• FlyBaseID: FBgn0261987
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_000953.2
• Gene: PTGS1 / 5742
• HGNCID: 9604
• Length: 599
• Species: Homo sapiens
• Alignment Length: 834
• Identity: 168/834 - (20%)
• Similarity: 253/834 - (30%)
• Gaps: 308/834 - (36%)

  Fly     1 MSRIL---FILLLLIVTQLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLK 62
            |||.|   |:|.||::..|..|.|              |...|.|                  :.
Human     1 MSRSLLLWFLLFLLLLPPLPVLLA--------------DPGAPTP------------------VN 33

  Fly    63 KC--LPCSDGIRCVPQIQCPAHVRMESHEKPQICDLPAGKFGYCCETGQNHTAPKPETSPKERRS 125
            .|  .||.....||       ...::.::    ||        |..||.               |
Human    34 PCCYYPCQHQGICV-------RFGLDRYQ----CD--------CTRTGY---------------S 64

  Fly   126 GFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVM 190
            | |....|.:....|.:.             |..|.|.|.|:.|...   ...|..:....|.:|
Human    65 G-PNCTIPGLWTWLRNSL-------------RPSPSFTHFLLTHGRW---FWEFVNATFIREMLM 112

  Fly   191 TTQLFGKKEQVP-------VEDFIT----NNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTC 244
            ...|..:...:|       ..|:|:    :||.. :|.                  :..|:...|
Human   113 RLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSY-YTR------------------ILPSVPKDC 158

  Fly   245 NNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLSDVDRPHPK-YN 308
            ..|      .|..|   ::.||.|.                 |.||   |.||.....|.|: .|
Human   159 PTP------MGTKG---KKQLPDAQ-----------------LLAR---RFLLRRKFIPDPQGTN 194

  Fly   309 LMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGV 373
            ||...|.|...|...:||                ||:
Human   195 LMFAFFAQHFTHQFFKTS----------------GKM---------------------------- 215

  Fly   374 RCLNFVRLSLVPSPDCQLSYGKQLTK-VTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRD 437
                                |...|| :.|.||...:||.:.|....||.|:.|:|:.....| :
Human   216 --------------------GPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDG-E 259

  Fly   438 LLPLTNDKKACPSEEAGKSCFHSGDGRTNQ------------IISLITLQILLAREHNRVAGALH 490
            :.|        ||.|......|...|...|            :..|:....|..||||||...|.
Human   260 MYP--------PSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLK 316

  Fly   491 ELNPSASDETLFQEARRIVIAEMQHITYNEFL--------------PIIIGPQQMKRFRLVPLHQ 541
            ..:|:..||.|||..|.|:|.|...|...|::              .::.|.|...|.|:.   .
Human   317 AEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIA---M 378

  Fly   542 GYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQI-RQEHGRIDEVVNIPDVMFNPSRMRKREF 605
            .::|.|:                  .|..:...|:: .||:       :....:||.|.:
Human   379 EFNHLYH------------------WHPLMPDSFKVGSQEY-------SYEQFLFNTSML----- 413

  Fly   606 YDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAP 670
            .|..:..|.....:|:...|..|      |..:...|.:|...|:..|:..|:.:|:|.:..|..
Human   414 VDYGVEALVDAFSRQIAGRIGGG------RNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMK 472

  Fly   671 KLHSFEQF--PIEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGD- 732
            ...||::.  ..|:|.:|..:|...|.::.:.|.||||.....:.|.:..||.|....:...|:
Human   473 PYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNP 537

  Fly   733 ----RYYYEYDNGINPGAF-NPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAF 781
                .|:       .|..| ..:....::..||.:|:|     |..:..|..:|
Human   538 ICSPEYW-------KPSTFGGEVGFNIVKTATLKKLVC-----LNTKTCPYVSF 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337	8/51 (16%)
		An_peroxidase	237..772	CDD:281139	120/571 (21%)
		peroxinectin_like	396..767	CDD:188655	93/406 (23%)
PTGS1	NP_000953.2	EGF_CA	32..69	CDD:238011	13/71 (18%)
		prostaglandin_endoperoxide_synthase	89..575	CDD:188648	134/660 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810