DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and ptgs2b

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001020675.1	Gene:	ptgs2b / 559020	ZFINID:	ZDB-GENE-041014-323	Length:	606	Species:	Danio rerio

Alignment Length:	730	Identity:	149/730 - (20%)
Similarity:	238/730 - (32%)	Gaps:	226/730 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 CDLPAGKFGYCCET---------------GQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNF 143
            |..|....|.|.|.               |||.|.|:..|..|       ..|.|:
Zfish    24 CSHPCQNRGVCTEMGSDAYECDCTRTGYYGQNCTTPEFLTWVK-------VSLKPS--------- 72

  Fly   144 EHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVEDFIT 208
                            |:..|.::.|..:   |.|. |:|.:                    |:.
Zfish    73 ----------------PNTVHYILTHFKS---LWNI-INNVS--------------------FLR 97

  Fly   209 NNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGI 273
            |.: :::..|..||....||.. |....|:|.:...|.....|:|     .|:.|..|
Zfish    98 NGI-MRYVLTSRAHLIDSPPTF-NADYGYKSWEAYSNLSYYTRTL-----PPVPRDCP------- 148

  Fly   274 WTP-----RAHSSDGTPLLGARKISRTLLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDG 333
             ||     :....|...|.....:.|..:.|..|.    |||...|.|...|
Zfish   149 -TPMGVAGKKELPDVKMLAEKLLLRRKFIPDPQRT----NLMFAFFAQHFTH------------- 195

  Fly   334 SLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLSYGKQL- 397
                                            :||.:                   .:..|...
Zfish   196 --------------------------------QFFKS-------------------DMKKGPAFT 209

  Fly   398 TKVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRDLLPLTNDKKA---CPSEEAGKSCFH 459
            |.:.|.||.:.:||.:.:....||.|:.|:||.....|....|..::.:.   .|........|.
Zfish   210 TALNHGVDLAHIYGQNLDRQHKLRLFKDGKLRYQILDGEVYPPTVSEVQVDMHYPPHVPESRRFA 274

  Fly   460 SGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPI 524
            .|......:..|:....:..||||||...|.:.:|...||.|||.:|.|:|.|...|...:::..
Zfish   275 VGHEAFGLVPGLMMYATIWLREHNRVCDILKQEHPDWDDERLFQTSRLILIGETIKIVIEDYVQH 339

  Fly   525 IIG--------PQQM--KRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQ 579
            :.|        |:.:  :||:       |.:        .|::||: ..|.. |..:...|.|:
Zfish   340 LSGYYFKLKFDPELLFNERFQ-------YQN--------RISSEFN-TLYHW-HPLMPDDFHIQ- 386

  Fly   580 EHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNPFGLDL 644
                 |||.|....:||.|.:.     |..:.:|.....:|:...::.|      |...|..|.:
Zfish   387 -----DEVYNYQQFLFNTSILT-----DYGVNSLVESFNKQIAGRVAGG------RNVAPAVLRV 435

  Fly   645 AAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQF--PIEIAQKLSRVYRTPDDIDLWVGGLLEKA 707
            |..:|:..|....:|.|.|.:........|||:.  ..|:|.:|..:|...|.::|:.|.|:||.
Zfish   436 AIKSIENSRQMRYQSINAYRKRFNMKPYRSFEEMTGEKEMAAELEEMYGDVDAVELYAGLLVEKP 500

  Fly   708 VEGGVVGVTFAEIIADQFARFKQGD-----RYYYEYDNGINPGAF-NPLQLQEIRKVTLARLLCD 766
            ....:.|.|..|:.|....:...|:     .|:       .|..| ..:..:.:...:|..|:|:
Zfish   501 RSNAIFGETMVEMGAPYSLKGLMGNPICSPEYW-------KPSTFGGKVGFEIVNSASLQNLVCN 558

  Fly   767 NSDRLTLQAVPLAAF 781
            |.:    ...|:|:|
Zfish   559 NVN----GPCPMASF 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337	10/39 (26%)
		An_peroxidase	237..772	CDD:281139	117/561 (21%)
		peroxinectin_like	396..767	CDD:188655	92/392 (23%)
ptgs2b	NP_001020675.1	EGF_CA	21..57	CDD:238011	8/32 (25%)
ptgs2b	NP_001020675.1	prostaglandin_endoperoxide_synthase	77..565	CDD:188648	131/639 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810