DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and cd

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	208/587 - (35%)
Similarity:	310/587 - (52%)	Gaps:	32/587 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 YRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLSDVD 301
            ||...|.|||.:..|: :||:..|..||:.|.|.|||..||.......|  .||::|..:.....
  Fly   218 YRRSTGVCNNKQHPRT-YGASMVPYRRMVSPDYADGIAAPRVSHHGRLP--PARQVSLKIHRSSY 279

  Fly   302 RPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDE 366
            .....:.:|:..|||.:.|||:.||....::|..:.||     ||.:.:| |..|.|:.:.|||.
  Fly   280 ETDSNFTVMLAVFGQFMDHDITATSLTTSQEGESIDCC-----VAATREQ-HPECYPVDILPDDP 338

  Fly   367 FFSAFGVRCLNFVRLSLVPSPDCQLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAFRGGRLRM- 430
            ::..:.:.|:||||.:  |:|..:.....||.:.|.|:|||.|||:.::....||:|..|.|||
  Fly   339 YYKQYNISCMNFVRSA--PAPTGRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLRMF 401

  Fly   431 MNDFGRDLLPL-TNDKKAC---PSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHE 491
            :.|.||.|||: :|....|   .....||.||.|||.|.|:.:.|.::.:|.||.||.:|..|.|
  Fly   402 VTDDGRQLLPISSNPADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQE 466

  Fly   492 LNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPL-HQGYSHD-YNVNVNPA 554
            .||...||.|:||||:|:.|:|.|||||||||:::|....:...|:|. |...:.| |:..|:|:
  Fly   467 QNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDTYDPEVDPS 531

  Fly   555 ITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQ 619
            |.|.|:.||:|..|:.:.|.|.|.:::. ..|.:.:..::|||..:......|..|.|..:.|:.
  Fly   532 IANCFAAAAFRFAHTLLPGLFNISRDNS-TPEAIELHKMLFNPFSLWAEHGIDHALMTAANTPVM 595

  Fly   620 QVDSSISQGLSRFLFRGDN----PF-GLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFP 679
            |||...|..:::.||.|..    |. ||||.::|||||||.|:.||..:......|.:.::|:..
  Fly   596 QVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMS 660

  Fly   680 IEI----AQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDN 740
            ..|    ...:.::|.:|.|:|::.|.|.|..::|.:.|...:.:::|||.|.|.||.::||...
  Fly   661 QAIDNATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKM 725

  Fly   741 GINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLE 805
            |  |..|...||.||.|.:||.::|.|||.:|  .|......|....||..:.|.|......|.|
  Fly   726 G--PQKFTKAQLAEIYKTSLAAIICRNSDGIT--RVREHVMQRLRDGGNPHVDCQDLEGFHFNFE 786

  Fly   806 AW 807
            .|
  Fly   787 PW 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337
		An_peroxidase	237..772	CDD:281139	198/550 (36%)
		peroxinectin_like	396..767	CDD:188655	144/386 (37%)
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	198/550 (36%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	144/388 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I2076
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970