DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and Irc

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	182/707 - (25%)
Similarity:	301/707 - (42%)	Gaps:	129/707 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LVFHSTAKDDLH------------NFAISNSAIE--QVMTT--QLFGKKEQVPVEDFITNNVPIK 214
            |.:..||.|.::            :..:.|.::.  |::.|  .|..||:         |.:.:|
  Fly    43 LQYVETALDSVNRQKRLEDNLLGSDITVKNGSLSHAQLLDTLPSLASKKD---------NKLALK 98

  Fly   215 FTETPLA---HHCQPPPVCGNIRSVYRSM----DGTCNNPEPQRSLWG--AAGQPMERMLPPA-Y 269
            ..::.|.   ..|.|..:.|:....|...    :|:....|.:.||.|  .......|:|..: |
  Fly    99 ILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECENSLKGNREGHYAFRRLLGSSHY 163

  Fly   270 EDGIWTPRAHSSDGTPLLGARKISRTL-------LSDVDRPHPKYNLMVMQFGQVLAHDISQTSS 327
            .:|.:....:|.....:..|..||:.|       :|.........||.:.|:.|.:.||:|:..|
  Fly   164 RNGFYQMFPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDLSKPVS 228

  Fly   328 IRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLS 392
            ..:.:|:.::|||.: ::.|.|:..|.||.||..:|..::...   .|||:||.:|..: ||...
  Fly   229 QSMSNGAPIECCSRD-QINLQPRHHHPACAPILYQPGGKYDVP---SCLNYVRSALAVA-DCNFG 288

  Fly   393 YGKQLTKVTHFVDASPVYGSSDEASRSLRAFRGGRLRM--MNDFGRDLLPLTNDKKA---CPSEE 452
            ..:||.:.|..:|.|.:||.:..|.|.||...||.||.  ..:|...|||:..|.:.   |....
  Fly   289 GAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFCARAT 353

  Fly   453 AGK-SCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHI 516
            .|. :||.:||.|.|.....|.:..:..|.||:||..|.:.||..|||.|||.|:.:.:...:.:
  Fly   354 IGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRV 418

  Fly   517 TYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGK------- 574
            ...|:||.::|.:.....|....::...          ::|||:.||.|...|.:..:
  Fly   419 VIEEWLPEVLGQKMSSEIRRKQPNRALE----------VSNEFAVAAIRFYFSMLPNELLNLTKD 473

  Fly   575 ------------------------FQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYS 615
                                    |::::|             ::.|......:..:::|.:|.:
  Fly   474 NVVYGTEKNNQYVFISKELPTKNLFELKEE-------------IYKPKLQYTSQKLNNILESLLN 525

  Fly   616 QPMQQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLE--LMGAP--KLHSFE 676
            |...::|::.|.|:  ...:...|...|:.|.:||||||.||..|..|||  ::..|  ....||
  Fly   526 QETMKMDAAYSGGV--VWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFE 588

  Fly   677 QF-PIEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFAR-FKQGDRYYYEYD 739
            .| |.::..||..:|.:..|:||.|||:.|..|.|. :|.||:.||::||.. .||..:...:..
  Fly   589 HFIPSDVLDKLKTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLKQNQQKAVQKH 652

  Fly   740 NGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDD 796
            ..:         :::.|.....:|||.||.   |.|||...| :.....|||:.|:|
  Fly   653 TEL---------VEQYRHFNGTKLLCLNSG---LSAVPQNIF-QLPSARNQMVSCED 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337
		An_peroxidase	237..772	CDD:281139	156/591 (26%)
		peroxinectin_like	396..767	CDD:188655	110/413 (27%)
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	148/560 (26%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	102/372 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I2076
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970