DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and Lpo

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_006247147.1	Gene:	Lpo / 287610	RGDID:	1310051	Length:	710	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	221/758 - (29%)
Similarity:	351/758 - (46%)	Gaps:	122/758 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PAGKFGYCCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNFEHLMH--GVAQIPVRRGF 159
            |..|....|:|.:...| ....:..:.||.....:| |.:...|...::|.|  |..:..:|
  Rat    27 PPAKTVIICDTVEEVKA-SVNKAFLDSRSRLKKAMS-AEVRSTRHLSDYLKHAKGRTRTAIR--- 86

  Fly   160 PDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHC 224
                :|.|:..:.| .|..| ::|:..:.:..|.||.|.                        .|
  Rat    87 ----NGQVWEESLK-KLTQF-LTNATGQGLDLTSLFWKV------------------------GC 121

  Fly   225 QP--PPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGI-----WTPRAHSSD 282
            .|  |.|..||.:.||::.|.|||  .:....|:|.:.:.|.||..||||:     ||| ..:.:
  Rat   122 NPPAPAVTCNISNPYRTITGDCNN--RKNPALGSANRALARWLPAEYEDGLSLPFGWTP-GKTRN 183

  Fly   283 GTPLLGARKISRTL---LSDVDRPHPKYNLMVMQFGQVLAHDI--SQTSSIRLEDGSLVQCCSPE 342
            |.||...|::|..:   |::.|....|.:::.||:||::.||:  :..:.:..::.:..||
  Rat   184 GYPLPQPREVSNQIAGYLNEEDVLDQKRSVLFMQWGQIVDHDLDFAPDTEMGTDNYTKAQC---- 244

  Fly   343 GKVALSPQQSHFA----CMPIHVEPDDEFFSAFGVRCLNFVRLSLV-PSPDCQLSYGKQLTKVTH 402
                    ..|..    |.||.....|......| :|::|.|...| |:|..|....:|:..:|.
  Rat   245 --------DEHCIQGDNCFPIMFPTGDPKLKTQG-KCMSFFRAGFVCPTPPYQSLTREQINALTS 300

  Fly   403 FVDASPVYGSSDEASRSLRAFRG--GRLRM---MNDFGRDLLPLTNDKKACPSE----EAGKSCF 458
            |:|||.||......:..||....  |.:.:   ::|.||...|... .|..|.|    .||..||
  Rat   301 FLDASLVYSPEPSMANRLRNLSSPLGLMAVNEEVSDHGRPFPPFVK-MKPSPCEVINATAGVPCF 364

  Fly   459 HSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLP 523
            .:||.|.::.|.|.|...|..|||||:|..|..|||....|||:||.|:|:.|.:|.||:.::||
  Rat   365 LAGDSRASEQILLATSHTLFIREHNRLARELSTLNPHWDGETLYQETRKIMGAFIQIITFRDYLP 429

  Fly   524 IIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDE-- 586
            |::|.:..|   .:|.:||    ||.:|:|.|:|.|: .|:|.||      .:|.....|:||
  Rat   430 ILLGDEMQK---WIPPYQG----YNESVDPRISNVFT-FAFRFGH------LEIPSTVSRLDENY 480

  Fly   587 -------VVNIPDVMFNPSRMRKREFYDDMLRTLYSQ--PMQQVDSSISQGLSRFLFRGDNPF-G 641
                   .:.:..|.||..|:.|....|.::|.|.::  .:...|..::..|...||:..:.. |
  Rat   481 QPWGSEPELPLHTVFFNTWRLVKDGGIDPLVRGLLAKKAKLMHQDRMMTGELRNKLFQPTHTIHG 545

  Fly   642 LDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPI-----EIAQKLSRVYRTPDDIDLWVG 701
            .|||:|||||.||.|:..||.:....|..:..:.|:...     .:|:||..:|.||.:||:|:|
  Rat   546 FDLASINIQRCRDHGMPGYNSWRAFCGLSQPKTLEELSAVMENEVLAKKLLDLYGTPSNIDIWLG 610

  Fly   702 GLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARLLCD 766
            .:.|..|.||.||.....::..||.|.:.|||:::|     |||.|...|.:.::|::.:||:||
  Rat   611 AIAEPLVPGGRVGPLLTCLLGHQFQRVRDGDRFWWE-----NPGVFTEKQRESLQKLSFSRLVCD 670

  Fly   767 NSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAWRA 809
            |:.   :..|||..|:...:| :..:.|.  ::..::|..|.|
  Rat   671 NTG---ITKVPLNPFLANTYP-HGFVDCS--SVDKLDLSPWAA 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337	5/21 (24%)
		An_peroxidase	237..772	CDD:281139	182/575 (32%)
		peroxinectin_like	396..767	CDD:188655	133/396 (34%)
Lpo	XP_006247147.1	An_peroxidase	136..675	CDD:281139	182/577 (32%)
Lpo	XP_006247147.1	myeloperoxidase_like	281..692	CDD:188656	144/434 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820