Protein Alignment Pxt and Tpo

DIOPT Version :10

• Sequence 1: NP_650648.3
• Gene: Pxt / 42131
• FlyBaseID: FBgn0261987
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: XP_011242158.1
• Gene: Tpo / 22018
• MGIID: 98813
• Length: 915
• Species: Mus musculus
• Alignment Length: 764
• Identity: 235/764 - (30%)
• Similarity: 361/764 - (47%)
• Gaps: 132/764 - (17%)

  Fly   104 CCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNF-EHLMHGVAQIPVRRGFPDFAHGLV 167
            |.:|.::|.....|||        ..::..||.:..:||. :..:...||:......|:...|
Mouse    31 CGKTMKSHVISAVETS--------QLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSG-- 85

  Fly   168 FHSTAKDDLHNFAISNSAIEQVMTTQL-FGKKEQVPVEDFITNNVPIKFTETPLAH--HCQP--- 226
                        |||.:|  ::|.|.: ..|:||   ..|.|:.:......| :|:  .|.|
Mouse    86 ------------AISRAA--EIMETSIQVMKREQ---SQFSTDALSADILGT-IANLSGCLPFML 132

  Fly   227 PPVCGN--IRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSD----GTP 285
            ||.|.:  :.:.||.:.|.|||.:..|  |||:...:.|.|||.||||...|:..:.:    |.|
Mouse   133 PPRCPDTCLANKYRPITGACNNRDHPR--WGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFP 195

  Fly   286 LLGARKISRTLL---SDVDRPHPKYNLMVMQFGQVLAHDIS----QTSSIRLEDGSLVQC---CS 340
            |...|:::|.|:   ::......:|:..:..:||.:.|||:    .||:.....|  |.|   |
Mouse   196 LPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGG--VDCQLTC- 257

  Fly   341 PEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLV-PSPDCQLSYG--------KQ 396
                      ::...|.||.:..:....:|    ||.|.|.|.. .:.|....:|        :|
Mouse   258 ----------ENQNPCFPIQLPSNSSGTTA----CLPFYRSSAACGTGDQGALFGNLSAANPRQQ 308

  Fly   397 LTKVTHFVDASPVYGSSDEASRSLR--AFRGGRLRMMN---DFGRDLLPLTNDKKACPSEEA--- 453
            :..:|.|:|||.|||||....:.||  :...|.||:..   |.||..||...  .||..|..
Mouse   309 MNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFAT--AACAPEPGTPR 371

  Fly   454 --GKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHI 516
              ...||.:||||.:::.:|..:..|..|||||:|.|...:|...|..|.:||||::|.|..|.|
Mouse   372 TNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQII 436

  Fly   517 TYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIR--- 578
            |..:::|.|:||...:::  |..::|    ||..|||.::|.||.||:|.||::|..  .:|
Mouse   437 TMRDYIPKILGPDAFRQY--VGPYEG----YNPTVNPTVSNIFSTAAFRFGHATVHP--LVRRLN 493

  Fly   579 ---QEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQ-QVDSSI-SQGLSRFLFRGDN 638
               |||..:.. :.:.||.|.|.|:.:....|.::|.|.::..: ||...: ::.|:..||...|
Mouse   494 TDFQEHTELPR-LQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSN 557

  Fly   639 PFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIEI---------AQKLSRVYRTPD 694
            ...||||::|:|||||.||..||::.|..|..:|.:    |.|:         ..|:..:|:..|
Mouse   558 VGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLET----PAELNKAIANRSMVNKIMDLYKHAD 618

  Fly   695 DIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVT 759
            :||:|:|||.||.:.|...|..||.||..|....:.|||:::|     |...|...|.||:.|.:
Mouse   619 NIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWE-----NTNVFTDAQRQELEKHS 678

  Fly   760 LARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAWR 808
            |.|::|||:.   |..||:.||.....| .....|:|  :||::||.||
Mouse   679 LPRVICDNTG---LTRVPVDAFRIGKFP-QDFESCED--IPSMDLELWR 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	An_peroxidase	237..781	CDD:460804	192/593 (32%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	195/604 (32%)
		CCP	730..783	CDD:153056
		EGF_CA	784..813	CDD:429571