Protein Alignment Pxt and Ptgs2

DIOPT Version :10

• Sequence 1: NP_650648.3
• Gene: Pxt / 42131
• FlyBaseID: FBgn0261987
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_035328.2
• Gene: Ptgs2 / 19225
• MGIID: 97798
• Length: 604
• Species: Mus musculus
• Alignment Length: 610
• Identity: 125/610 - (20%)
• Similarity: 213/610 - (34%)
• Gaps: 165/610 - (27%)

  Fly   207 ITNNVP------IKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERML 265
            |.||:|      :|:..|..::....||.. |:...|:|.:...|     .|.:       .|.|
Mouse    87 IVNNIPFLRSLIMKYVLTSRSYLIDSPPTY-NVHYGYKSWEAFSN-----LSYY-------TRAL 138

  Fly   266 PPAYEDGIWTPRAHSSDGTPLLGARK--ISRTLLSDVDRPHPK-YNLMVMQFGQVLAHDISQTSS 327
            ||..:|   .|......|...|...|  :.:.||.....|.|: .|:|...|.|...|
Mouse   139 PPVADD---CPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTH------- 193

  Fly   328 IRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLS 392
                                                  :||.....|...|.|
Mouse   194 --------------------------------------QFFKTDHKRGPGFTR------------ 208

  Fly   393 YGKQLTKVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRDLLPLTNDKKA---CPSEEAG 454
                  .:.|.||.:.:||.:.:....||.|:.|:|:.....|....|...|.:.   .|.....
Mouse   209 ------GLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPE 267

  Fly   455 KSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAE------- 512
            ...|..|......:..|:....:..||||||...|.:.:|...||.|||.:|.|:|.|
Mouse   268 NLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIE 332

  Fly   513 --MQHIT-YN---EFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSV 571
              :||:: |:   :|.|.::..||.:          |.:        .|.:||:
Mouse   333 DYVQHLSGYHFKLKFDPELLFNQQFQ----------YQN--------RIASEFN----------- 368

  Fly   572 DGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRG 636
                .:...|..:.:..||.|..::    .|:..|::.:  |....:.|...|.::.::..:..|
Mouse   369 ----TLYHWHPLLPDTFNIEDQEYS----FKQFLYNNSI--LLEHGLTQFVESFTRQIAGRVAGG 423

  Fly   637 DN-PFGLD-LAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQF--PIEIAQKLSRVYRTPDDID 697
            .| |..:. :|..:|.:.|:...:|.|:|.:........|||:.  ..|:|.:|..:|...|.::
Mouse   424 RNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVME 488

  Fly   698 LWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGD-----RYYYEYDNGINPGAF-NPLQLQEIR 756
            |:...|:||.....:.|.|..|:.|....:...|:     :|:       .|..| ..:..:.|.
Mouse   489 LYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYW-------KPSTFGGEVGFKIIN 546

  Fly   757 KVTLARLLCDNSDRLTLQAVPLAAF 781
            ..::..|:|:|     ::..|..:|
Mouse   547 TASIQSLICNN-----VKGCPFTSF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	An_peroxidase	237..781	CDD:460804	115/572 (20%)
Ptgs2	NP_035328.2	EGF_CA	19..55	CDD:238011
		prostaglandin_endoperoxide_synthase	75..562	CDD:188648	123/604 (20%)