DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxt and Ptgs1

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_032995.1	Gene:	Ptgs1 / 19224	MGIID:	97797	Length:	602	Species:	Mus musculus

Alignment Length:	554	Identity:	122/554 - (22%)
Similarity:	193/554 - (34%)	Gaps:	142/554 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 TLLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSI-------RLEDGSLVQCCSP---EGKVAL-- 347
            |:.|::....|.||         .|||.....|.       |:.......|.:|   :||..|
Mouse   120 TVRSNLIPSPPTYN---------SAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPD 175

  Fly   348 ----------------SPQQSH--FACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLSYG 394
                            :||.::  ||....|.  ..:||...|                   ..|
Mouse   176 VQLLAQQLLLRREFIPAPQGTNILFAFFAQHF--THQFFKTSG-------------------KMG 219

  Fly   395 KQLTK-VTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRDLLP-------LTNDKKACPSE 451
            ...|| :.|.||...:||.:.|....||.|:.|:|:.....|....|       |.......|.|
Mouse   220 PGFTKALGHGVDLGHIYGDNLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPE 284

  Fly   452 E---AGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAE- 512
            .   .|:..|       ..:..|:....:..||||||...|.|.:|:..||.|||..|.|:|.|
Mouse   285 RQMAVGQEVF-------GLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGET 342

  Fly   513 --------MQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHS 569
                    :||:: ..||.:...|:.:.|.:.             .....|..||:...:  .|.
Mouse   343 IKIVIEEYVQHLS-GYFLQLKFDPELLFRAQF-------------QYRNRIAMEFNHLYH--WHP 391

  Fly   570 SVDGKFQI-RQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFL 633
            .:...||: .||:       :....:||.|.:     .|..:..|.....:|....|..|
Mouse   392 LMPNSFQVGSQEY-------SYEQFLFNTSML-----VDYGVEALVDAFSRQRAGRIGGG----- 439

  Fly   634 FRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQF--PIEIAQKLSRVYRTPDDI 696
             |..:...|.:|...|:..|:..|:.:|:|.:..|.....||::.  ..|:|.:|..:|...|.:
Mouse   440 -RNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSFQELTGEKEMAAELEELYGDIDAL 503

  Fly   697 DLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGD-----RYYYEYDNGINPGAF-NPLQLQEI 755
            :.:.|.||||.....:.|.:..|:.|....:...|:     .|:       .|..| ..:....:
Mouse   504 EFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNPICSPEYW-------KPSTFGGDVGFNLV 561

  Fly   756 RKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGN 789
            ...:|.:|:|     |..:..|..:|...|:||:
Mouse   562 NTASLKKLVC-----LNTKTCPYVSFRVPDYPGD 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337
		An_peroxidase	237..772	CDD:281139	116/535 (22%)
		peroxinectin_like	396..767	CDD:188655	92/399 (23%)
Ptgs1	NP_032995.1	EGF_CA	35..72	CDD:238011
Ptgs1	NP_032995.1	prostaglandin_endoperoxide_synthase	92..578	CDD:188648	117/540 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810