back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and pxn-1

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	230/736 - (31%)
Similarity:	355/736 - (48%)	Gaps:	113/736 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 TSPKERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAIS 182
            |:..:|...|.|......|.:||..:|..:..|.:        ....||:.:   .|:||...:|
Worm   544 TNDLKRLFRFSTPKQAVELSKAREIYEESVRLVRE--------HVEKGLILN---VDELHPKNVS 597

  Fly   183 NSAIEQVMTTQ-LFGKKEQVPVEDFITNNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNN 246
            ..::..|...| |.|      :....|.......|:|...|.             |||.||.|||
Worm   598 YESVLHVTHVQALMG------LSGCHTGQYKNPCTDTCFHHR-------------YRSFDGQCNN 643

  Fly   247 PEPQRSLWGAAGQPMERMLPPAYEDGIWTP----RAHSSDGTPLLGARKISRTLLSDVD-RPHPK 306
              ..:.:.|.:..|:.|:|.|.||:|..||    :....:|.||...|::||.|::..: .||.|
Worm   644 --KNKPMTGVSLMPLRRLLKPVYENGFNTPVGWEKGRLYNGYPLPNVREVSRQLVATENITPHSK 706

  Fly   307 YNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAF 371
            .:.||||:||.:.||::.|.:      :|.:.....|.......::...|..|.:.|:|....:.
Worm   707 LSSMVMQWGQFVDHDLTHTVT------ALSRHSYATGAFCNRTCENLDPCFNIPLSPNDPRVKSG 765

  Fly   372 GVR--CLNFVRLSLVPSPDC----------QLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAF- 423
            ..:  |:.|.|.:.|    |          :::|.:|:..:|.|:|||.||||::..::.||..
Worm   766 SAKYPCIEFERSAAV----CGSGETSLVFNRVTYREQMNALTSFLDASNVYGSNEVQAQELRDTY 826

  Fly   424 -RGGRLR--MMNDFGRDLLPLTNDKKA-CP---SEEAGKSCFHSGDGRTNQIISLITLQILLARE 481
             ..|.||  :.::.|::.||...|... |.   |||....||.:||.|.|:.::|.....:..||
Worm   827 NNNGMLRFDITSEAGKEYLPFEKDSNMDCRRNFSEENPIRCFLAGDLRANEQLALAATHTIFIRE 891

  Fly   482 HNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQ-QMKRFRLVPLHQGYSH 545
            |||:|..|..:|.:...|.::.|.|:||.|.||||||..::|||.|.| ||.:|  |..:|||..
Worm   892 HNRIAKKLKSMNGNWDGEIIYHETRKIVGAMMQHITYKHWMPIIFGGQAQMNKF--VGTYQGYDP 954

  Fly   546 DYNVNVNPAITNEFSGAAYRMGHSSVD-GKFQIRQEHGRIDE-VVNIPDVMFNPSRMRKREFYDD 608
            |    |:.::||.|:.||:|.||:.:: ..|::..:...|.| .:.:....|.|..:..:...|.
Worm   955 D----VDASVTNAFATAAFRFGHTIINPSLFRLGNDFMPIKEGHIALHKAFFTPELVLTQGGVDP 1015

  Fly   609 MLRTLYSQPMQ--QVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPK 671
            :||.|::.|::  .....::..|...||...:...||||.:||||.||.||.||.:|.:....|
Worm  1016 LLRGLFASPLKHPMPTQLLNMELIEKLFMKGHEVSLDLAVMNIQRSRDHGLPSYTEYRKFCNLP- 1079

  Fly   672 LHSFEQFPIE------------IAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQ 724
                  .|::            |.|||..:|..|.:|||||||::|:.:|.|:.|.|||.||.:|
Worm  1080 ------VPVQWEDMKGYIKDDMIIQKLRGLYGVPQNIDLWVGGIVEEKLENGLFGPTFACIIGEQ 1138

  Fly   725 FARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPG- 788
            |.:.:.|||::||.|     |.|.|.||:||:|:|||||.|||.|  .:..:....|:   :||
Worm  1139 FRKIRDGDRFWYEKD-----GVFTPEQLREIKKITLARLFCDNGD--NIDRIQKDVFM---YPGM 1193

  Fly   789 -NQMIG-CDDPNLPSVNLEAW 807
             .:..| |.:..:  :||.||
Worm  1194 DKENYGTCQETEM--MNLRAW 1212

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.