DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and pxn-2

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_509834.1	Gene:	pxn-2 / 181288	WormBaseID:	WBGene00004257	Length:	1328	Species:	Caenorhabditis elegans

Alignment Length:	836	Identity:	244/836 - (29%)
Similarity:	377/836 - (45%)	Gaps:	157/836 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIVTQLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLKKCLPCSDGIRCV 74
            ||:..:|:|           :.|::.|..|...:|  .|:.:|.|||.|....:
Worm   531 LLVGAELTE-----------KVDKLLDDSTIEKIA--KEAKQKVEKALSSTKDQ----------- 571

  Fly    75 PQIQCPAHVRMESHEKPQICDLPAGKFGYCCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEA 139
                    .||:..|.|.  ||                         .:...|...|....|.:|
Worm   572 --------QRMDKIESPN--DL-------------------------SKLFKFAINLKKVDLGKA 601

  Fly   140 RRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVE 204
            |..:|..:. :.|:.:       .:||.|.|.    :.:..:|..|:..|...|...:|......
Worm   602 REIYEESIR-LVQMHI-------DNGLAFESA----MISPNVSYEAVLPVSYVQTLMEKSGCQTG 654

  Fly   205 DFITNNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAY 269
            .|..:          ...||        ..|.|||.||.|||.|  ...||.:.....|:|||.|
Worm   655 QFAES----------CEDHC--------FFSKYRSYDGQCNNHE--HPWWGVSEMAFMRLLPPRY 699

  Fly   270 EDGIWTP----RAHSSDGTPLLGARKISRTLL-SDVDRPHPKYNLMVMQFGQVLAHDISQTSSIR 329
            |:|..||    :....:|..:..|||:||.|: :|...||...:.|.||:||.:.||::.|:.
Worm   700 ENGFNTPVGWEKGKRYNGYEVPNARKVSRVLIGTDETTPHSHLSAMTMQWGQFIDHDLTLTAP-- 762

  Fly   330 LEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGV----RCLNFVRLSLV-----P 385
                :|.:....||.......::...|..|.:|.||..... |:    .|:.|.|....     .
Worm   763 ----ALTRHSYKEGAFCNRTCENADPCFNIQLEADDPKLHT-GLYQKHPCMEFERNGAACGSGET 822

  Fly   386 SPDCQ-LSYGKQLTKVTHFVDASPVYGSSDEASRSLRAFRG--GRLR--MMNDFGRDLLPLTNDK 445
            ||..| ::|..||..:|.::|||.:||:|:|.:..||....  |.||  :::...:..:|...|.
Worm   823 SPIFQRVTYRDQLNLLTSYLDASGIYGNSEEQALELRDLYSDHGLLRFDIVSGANKPYMPFEKDS 887

  Fly   446 KA-CP---SEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEAR 506
            .. |.   |.|....||.:||.|.|:.:.|:::..:..|||||:|..|.|:|.:...||:|||.|
Worm   888 DMDCRRNFSRENPIKCFLAGDVRANEQLGLMSMHTIFLREHNRIASRLLEVNENWDGETIFQETR 952

  Fly   507 RIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSV 571
            :::.|.:||||||.:||.|:|.....  .::..::|    ||.:|||.|.|||:.||.|..|:.:
Worm   953 KLIGAMLQHITYNAWLPKILGKATYN--TIIGEYKG----YNPDVNPTIANEFATAALRFAHTLI 1011

  Fly   572 -------DGKF-QIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQP--MQQVDSSIS 626
                   |..| :.:|.|      :.:.:..|.|.|:......|.:||.|::.|  |.:.|..::
Worm  1012 NTHLFRFDKDFKETKQGH------LPLHNAFFAPERLVSEGGVDPLLRGLFAAPIKMPRPDQVLN 1070

  Fly   627 QGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLEL--MGAPKLHSFEQFPIE---IAQKL 686
            :.|:..||...:...|||||:|||||||.||.|:.:|.:.  :..||..|..:..::   :..||
Worm  1071 KELTEKLFNRFHEVALDLAALNIQRGRDHGLPSWTEYRKFCNLTVPKTWSDMKNIVQNDTVISKL 1135

  Fly   687 SRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQ 751
            ..:|...::|||||||:.||.....::|.|.|.||||||.|.:.|||::||     |...|:..|
Worm  1136 QSLYGVTENIDLWVGGVTEKRTADALMGPTLACIIADQFKRLRDGDRFWYE-----NEEMFSKAQ 1195

  Fly   752 LQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAW 807
            |::|:||||::::|.|.|  .:..:....||...:.......|:  :||.:||..|
Worm  1196 LRQIKKVTLSKIICTNGD--DIDRIQRDIFVYHGNSTQFYEPCE--SLPEINLNMW 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337	6/51 (12%)
		An_peroxidase	237..772	CDD:281139	196/572 (34%)
		peroxinectin_like	396..767	CDD:188655	140/393 (36%)
pxn-2	NP_509834.1	LRRNT	16..43	CDD:396168
		leucine-rich repeat	28..44	CDD:275380
		PRK15370	<35..>155	CDD:185268
		leucine-rich repeat	46..69	CDD:275378
		LRR_8	47..104	CDD:404697
		leucine-rich repeat	70..93	CDD:275378
		leucine-rich repeat	94..116	CDD:275378
		leucine-rich repeat	117..140	CDD:275378
		leucine-rich repeat	141..154	CDD:275378
		Ig	346..432	CDD:416386
		Ig strand B	369..373	CDD:409353
		Ig strand C	382..386	CDD:409353
		Ig strand E	405..410	CDD:409353
		Ig strand F	419..424	CDD:409353
		I-set	445..533	CDD:400151	1/1 (100%)
		Ig strand A'	453..457	CDD:409353
		Ig strand B	460..469	CDD:409353
		Ig strand C	475..480	CDD:409353
		Ig strand C'	483..486	CDD:409353
		Ig strand D	491..496	CDD:409353
		Ig strand E	497..505	CDD:409353
		Ig strand F	512..520	CDD:409353
		Ig strand G	523..533	CDD:409353	1/1 (100%)
		peroxidasin_like	798..1238	CDD:188658	153/461 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820