DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pxt and skpo-1

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_495768.1	Gene:	skpo-1 / 174340	WormBaseID:	WBGene00009897	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	223/727 - (30%)
Similarity:	328/727 - (45%)	Gaps:	146/727 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 ETSPK------ERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDD 175
            |.:|:      ::..|..::.||..|...:           .:|..|.|.|           :.|
Worm    39 EVNPRWMKKHCQKACGTCSLTSPTPLTRQQ-----------DVPTARTFDD-----------QQD 81

  Fly   176 LHNFAISNSAIEQ----VMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHCQPPPVCG---NI 233
            ........|:|.:    |||.:...::      .|.:..:..:|.:...|.. |..|.|.   ..
Worm    82 RQFLPSRPSSIPEGCNSVMTVEAETRR------IFSSGQLTARFRQQMCAEE-QVAPDCSINQCF 139

  Fly   234 RSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLS 298
            ...||||||||||  .|..:.|||.....|::|.||:||..|..:.|....|  ..|::|..|||
Worm   140 HKKYRSMDGTCNN--LQNPVKGAAFTAFTRLMPAAYDDGFNTLVSASRRNRP--NPREVSVFLLS 200

  Fly   299 DVDRPHPKY-NLMVMQFGQVLAHDISQTSSIRLEDGSLVQC-CSPEGKVALSPQQSHFACMPIHV 361
            . :|..|.: |.::|.|||.::|||:..::...       | |...|.:          |..|..
Worm   201 S-ERSLPGHVNSLLMLFGQFVSHDITSNAAQNF-------CGCQNSGPM----------CASIFA 247

  Fly   362 EPDDEFFSAFGVRCLNFVRLSLVPSPDCQL-SYGK---QLTKVTHFVDASPVYGSSDEASRSLRA 422
            .|.|.     ..||:.|.|    ..|.|.. .:|:   ||...|..:|||.:|||....:||||.
Worm   248 PPSDR-----SRRCIPFTR----SFPICGTGQFGRVREQLNMNTAAIDASLIYGSEAITARSLRF 303

  Fly   423 FRGGRLRMMNDFGRDLLPLTNDKKACPSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAG 487
            ....|..|:.  ||...|.||           .....:||||....:.|..|.....|.||.||.
Worm   304 AAMLRTSMIG--GRMFPPNTN-----------PGSLTAGDGRAILFVGLAALHTSFLRLHNNVAA 355

  Fly   488 ALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVN 552
            .|..:|...:.:.:|||:|:||...:|.|||.||:|.:||.......       |..:.||.||.
Worm   356 RLQNMNRHWNADRIFQESRKIVGGIVQVITYQEFVPELIGDASKTIL-------GAYNGYNPNVE 413

  Fly   553 PAITNEFSGAAYRM------GHSSVDGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLR 611
            ..:.|||:..|||:      .:..|:.:||....:..||.|.||..|:.|         .|.:.|
Worm   414 IGVLNEFAAGAYRLHGMIQETYPLVNSQFQEVNRYRFIDGVNNINHVLNN---------IDAIYR 469

  Fly   612 TLYSQPM---QQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLH 673
            .:.:.|:   |::.:|:::.    ||.|    .:|:||:|||||||.||||||||........:.
Worm   470 GMMTVPVRSPQRLTTSVTER----LFGG----SVDMAAVNIQRGRDHGLRSYNDYRRFCNLRPIT 526

  Fly   674 SFEQFP----IEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRY 734
            ||..:|    ..:.|::.::||||||:|.:|||:||:...|.::|.|||.:|..||.|.:.|||:
Worm   527 SFNDWPEVPDENVRQRIGQLYRTPDDLDFYVGGILEQPAAGSLLGATFACVIGKQFERLRDGDRF 591

  Fly   735 YYEYDNGINPGAFNPLQLQEIRKVTLARLLC---DNSDRLTLQAVPLAAFVRADHPGNQMIGCDD 796
            |||     |||.|...||.|:::.||:.:||   ||..|:..:|..:       ..|::.:.|.
Worm   592 YYE-----NPGVFTSPQLAELKRTTLSWVLCQTGDNMVRVGRRAFDI-------ENGSRAVPCS- 643

  Fly   797 PNLPSVNLEAWR 808
             ::..:||||||
Worm   644 -SITGLNLEAWR 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337	1/1 (100%)
		An_peroxidase	237..772	CDD:281139	192/556 (35%)
		peroxinectin_like	396..767	CDD:188655	137/386 (35%)
skpo-1	NP_495768.1	ShKT	22..56	CDD:214586	3/16 (19%)
		An_peroxidase	143..623	CDD:281139	190/552 (34%)
		peroxinectin_like	275..619	CDD:188655	137/385 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49305
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830