DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pxt and skpo-3

DIOPT Version :9

Sequence 1:	NP_650648.3	Gene:	Pxt / 42131	FlyBaseID:	FBgn0261987	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_495511.1	Gene:	skpo-3 / 174191	WormBaseID:	WBGene00017968	Length:	1000	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	223/729 - (30%)
Similarity:	344/729 - (47%)	Gaps:	131/729 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PAVLDEARRNF----------------EHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAI 181
            |||....||.|                .|........|..|.|.:...    ::..:|.:::..:
Worm   348 PAVFFTTRRTFPPPTTTTTTTTQAPATTHFTREFTPPPTTRSFINTGS----NARCRDIINDPIV 408

  Fly   182 SNSAI---EQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHCQP--------PPVCGNIRS 235
            :...:   ..|:.|:...:::.|.::..|.:|.         |:.|.|        ..:|.|  :
Worm   409 AAEDMWRERLVVATEDNTRRQTVDLDQVIRSNT---------ANACTPRLDEADCEANICYN--A 462

  Fly   236 VYRSMDGTCNN--PEPQRSLWGAAGQPMERMLPPAYEDGIWTP-RAHSSDGTPLLGARKISRTLL 297
            ::|::||||||  .||.|   ||:.:|..|:||..|::.:..| .:..:|..|  ..|:|:|.|.
Worm   463 MFRTLDGTCNNMKGEPLR---GASYRPYTRLLPTIYDNEVSEPVGSLFTDARP--SPREITRRLT 522

  Fly   298 -SDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHV 361
             |......|.||.::|||||.::||:::|:.:            |..|..:. |.....||.:.:
Worm   523 SSQASVESPDYNALIMQFGQFISHDMAKTTLV------------PSSKCNVC-QNITSRCMSVPI 574

  Fly   362 EPDDEFFSAFGVRCLNFVRLSLVPSPDC---QLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAF 423
            ..||...:....:|:...|    .||.|   .|...:||.:.|.::||||:||||...|:..|..
Worm   575 TFDDSNANFRQAQCIRVSR----SSPICGSGNLKPRQQLNENTGYIDASPIYGSSVHDSKKFRDG 635

  Fly   424 RGGRLRMMNDFGRDLLPLTNDKKACPSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGA 488
            ..|.|::....|:..||.  |:..|.:.......|.:||.|.|..:.|.....:...||||:..|
Worm   636 NSGFLKLPMFNGKAFLPF--DQNKCRNRGQCSVIFTAGDSRVNLFVGLSAWHTIFTEEHNRLVTA 698

  Fly   489 LHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNP 553
            ...|||....|.|:||||:::.|::|.|.|.|:||.::|....   .:|..::||..|    |:.
Worm   699 FKRLNPHWDGERLYQEARKMIGAQVQAIVYREWLPKVLGASFA---TVVGDYRGYDSD----VDS 756

  Fly   554 AITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDML-------- 610
            .:.|||:.||:|.||..:...:|      |:|.  :..::.|.....:|...:.|:|
Worm   757 TVANEFTSAAFRFGHGMIQEFYQ------RLDN--SFRNISFGALPFQKGTLHSDVLVNEGGVDP 813

  Fly   611 --RTLYSQPM---QQVDSSISQGLSRFLFRGDNPFG-LDLAAINIQRGRDQGLRSYNDYLELMGA 669
              |.::||.:   |:|.::::          :|.|| .||:.||||||||.|..:|..|.||.|.
Worm   814 LIRGMFSQNVKRPQRVTTTVT----------ENMFGSTDLSTINIQRGRDHGHPAYVKYRELCGM 868

  Fly   670 PKLHSFEQFPIEI-----AQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFK 729
            ....:||....||     ..||..:|.:.|.||||||.|||..:..|:||.|.|.||..||.|.:
Worm   869 GTAFNFEHLSREILNTGTRNKLQEIYGSVDKIDLWVGALLEDPIIRGLVGPTVACIIGPQFKRTR 933

  Fly   730 QGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGC 794
            .|||:|||     |||.|:..||.||||.:|:|::|||::  |:..:|..|| |..|    |:.|
Worm   934 DGDRFYYE-----NPGVFSRRQLVEIRKSSLSRIICDNTN--TISTIPREAF-RVGH----MVPC 986

  Fly   795 DDPNLPSVNLEAWR 808
            .  .:||::|..||
Worm   987 S--QIPSMDLNQWR 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pxt	NP_650648.3	GH64-TLP-SF	<67..119	CDD:295337
		An_peroxidase	237..772	CDD:281139	189/560 (34%)
		peroxinectin_like	396..767	CDD:188655	138/389 (35%)
skpo-3	NP_495511.1	ShKT	41..75	CDD:214586
skpo-3	NP_495511.1	An_peroxidase	464..978	CDD:376988	191/569 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I1651
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.970