Protein Alignment osa and Arid1a

DIOPT Version :9

• Sequence 1: NP_001163639.1
• Gene: osa / 42130
• FlyBaseID: FBgn0261885
• Length: 2716
• Species: Drosophila melanogaster
• Sequence 2: XP_006539388.1
• Gene: Arid1a / 93760
• MGIID: 1935147
• Length: 2288
• Species: Mus musculus
• Alignment Length: 2815
• Identity: 785/2815 - (27%)
• Similarity: 1068/2815 - (37%)
• Gaps: 860/2815 - (30%)

  Fly     2 NEKIKSPQTQQQQQGG-APAPAATPPSAGAAPGAATP-PTSGPPTP------------------- 45
            :|..|:.|.|:::.|| |.|.||......||.|..:. |..|||.|
Mouse    21 SELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGG 85

  Fly    46 -NNNSNNGSDPSIQQQQQNVAPHP---YGAPPPPGSGPGG--------------------PP--- 83
             .:....|::|.::....|..|.|   ...|.|||.|.||                    ||
Mouse    86 AGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYG 150

  Fly    84 -----GPDPAAVMH-----YHHLHQQQQQHPPPPHMQQQQHHGGPAPPPPGGAPEHAPGVKEEYT 138
                 |..|:||..     :|..|..||.    |.:...|..||      ||...:|...:..:.
Mouse   151 FGQAYGRSPSAVAAAAAAVFHQQHGGQQS----PGLAALQSGGG------GGLEPYAGPQQNSHD 205

  Fly   139 HLPPPHPHPAYGRYHADPNMDPY------------RYGQP------LPGGKPPQQQQPHPQQQPP 185
            |..|.|   .|..|:  ||...|            |.|.|      ..|.|||          |.
Mouse   206 HGFPNH---QYNSYY--PNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPP----------PS 255

  Fly   186 QQPGPGGSPNRPPQQRYIP-----------GQPPQGPTPTLNSLLQSSNPPPPPQHRYANTY--D 237
            .......|.:...|||:..           |.|....|||||.||.|.:.....|......|  .
Mouse   256 SSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGG 320

  Fly   238 PQQ-----------------AAASAAAAAA----AQQQQAGGPPPPGH----GPP---PPQH--- 271
            ||.                 |||:||||||    |||:....|..||.    |.|   .||.
Mouse   321 PQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSP 385

  Fly   272 -------QPSPYGG------QQGGWAPPPRPYSPQLGPSQQY--RTP---PPTNTSRGQS----- 313
                   :|.||||      |||   ||..|......|.|.|  :||   |.|...|.||
Mouse   386 MDQMGKMRPQPYGGTNPYSQQQG---PPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSL 447

  Fly   314 -------PY----PPAHGQNSGSYPSSPQQQQQQQQQQQQQAGQQPGGPVPGGPP-----PGTGQ 362
                   ||    |.|:|| .|..|.  ..||....|||....|||....|...|     |.|.|
Mouse   448 SYAQQIPPYGQQGPSAYGQ-QGQTPY--YNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQ 509

  Fly   363 QPPQQNTPPTSQYSPYP--QRYPTP-PGLPAGGSNHRTAYSTHQYPEPNRPW-------PGGSSP 417
            ...|.:.||.||....|  |:.||| |...:....|..:...:..|:...|:       |..||.
Mouse   510 PQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSL 574

  Fly   418 SPGSGHPLP-PASPHHVPPLQQQPPPPPHVS--AGGPPPSSSPGHAPSPSPQPS-----QASPSP 474
            |..:.:|.| |.........||:.|||..:|  :.|...||:|....|...|..     |:.||.
Mouse   575 SQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSS 639

  Fly   475 HQELIGQ-------NSNDSSSGGAHSGMGSGPPGTPNP-QQVMRPTPSPTGSSGSRSMSPAVAQN 531
            ..:|.|.       .....|.|.:.||:.|......|| |....|..|| ...|.|..||:
Mouse   640 LPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSP-HLPGIRGPSPS---- 699

  Fly   532 HPISRPASNQSSSGGPMQQPPVGAGGPPPMPP--------HPGMPGGPPQQQQSQQQQASNSASS 588
             |:..|||...|..||:....|.....||.||        ||.|......|.:...|:
Mouse   700 -PVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQR------- 756

  Fly   589 ASNSPQQTPPPAPPPNQGMNNMATPPPPPQGAAGGGYPMPPHMHGGYKMGGPGQSPGAQGYPPQQ 653
               :||.....:|.|...::        |:..:||      .||.|.   |..|......|.||.
Mouse   757 ---NPQMPQYTSPQPGSALS--------PRQPSGG------QMHSGV---GSYQQNSMGSYGPQG 801

  Fly   654 PQQYPPGNYPPRPQYPPGAYATGPPPPPTSQAG-AGGANSMPSGAQAGGYPGRGMPNHTGQYPPY 717
            .|..|.|.||.:|.|.....|..|      .|| ||..|.|.:|.|..|.||         .|||
Mouse   802 SQYGPQGGYPRQPNYNALPNANYP------NAGMAGSMNPMGAGGQMHGQPG---------IPPY 851

  Fly   718 QWVPPSPQQTVPGGAPGGAMVGNHVQG--KGTPPPPVVGGP-PPPQGSGSPRPLNYLKQH----- 774
            ..:||        |....|.:||...|  ....||.|..|. |||.|.......:.:..|
Mouse   852 GTLPP--------GRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANS 908

  Fly   775 LQHKGGYGGSPTPPQGPQGYGNGPTGMHPGMPMGPPHHMGPPHGPTNMGPPTSTPPQSQMLQGGQ 839
            :|::            |.||.|    |:.|..||    .|||:|
Mouse   909 IQNR------------PPGYPN----MNQGGMMG----TGPPYG--------------------- 932

  Fly   840 PQGQGASGGPESGGPEHISQDNGISSSGPTGAAGMHAVTSVVTTGPDGTSMDEVSQQSTLSNASA 904
             ||..:..|.             |:..||....|                       .|::|.||
Mouse   933 -QGINSMAGM-------------INPQGPPYPMG-----------------------GTMANNSA 960

  Fly   905 ASGEDPQC-------TTPKSRKNDPYSQSHLAPPSTSPHPVVMHPGGGPGEEYDMSSPPNWPRPA 962
            .....|:.       .||.::.|:                                      :..
Mouse   961 GMAASPEMMGLGDVKLTPATKMNN--------------------------------------KAD 987

  Fly   963 GSPQVFNHVPVPQEPFRSTITTTKKSDSLCKLYEMDDNPDRRGWLDKLRAFMEERRTPITACPTI 1027
            |:|:.       :...:.:.::|..::.:.||||:...|:|:.|:|:..||.||:...:|..|.:
Mouse   988 GTPKT-------ESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAV 1045

  Fly  1028 SKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGASSSAAYTLRKHYTKNLLTFECHFDR 1092
            .::||||||||:.|||.||..:|.|:|.|:::|..|.:|.|||||.:|:|.|.:.|..|||..:|
Mouse  1046 GRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIER 1110

  Fly  1093 GDIDPLPIIQQVEAGSKKKTAKAASVPSPGGGHLDAG--TTNSTGSSNSQ--DSFPAPPGSAPNA 1153
            |: ||.|.|  ..|...||:......|||.|.....|  |..||.||.::  |..|..|.|.|::
Mouse  1111 GE-DPPPDI--FAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHS 1172

  Fly  1154 AIDGYPG------------YPGGSPYPVASGPQPDYATAGQMQRPPSQNNPQTPHPGAAAAVAAG 1206
            .|...||            :|.||        .|.:          .:.|..||:||...::...
Mouse  1173 QIPPLPGMSRSNSVGIQDAFPDGS--------DPTF----------QKRNSMTPNPGYQPSMNTS 1219

  Fly  1207 DNISVSN--PFEDPI-----AAGGGPGSGTGPGPGQGPG-PGAASGGAGAVGAVGGGPQPHPP-- 1261
            |.:...:  |.:||.     |.|..|...:|.||..|.| |.:.:.|.| :|:|..||:.|.|
Mouse  1220 DMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPG-LGSVAMGPRQHYPYG 1283

  Fly  1262 -------------PPHSPHTAAQQAAGQHQQQHPQHQHPGLPGPP--PPQQQQGQQGQQPPPSVG 1311
                         |..:..|.|.|     ....|.....|:..|.  ||||||.||.||
Mouse  1284 GPYDRVRTEPGIGPEGNMGTGAPQ-----PNLMPSTPDSGMYSPSRYPPQQQQQQQQQQ------ 1337

  Fly  1312 GGPPPAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSGYPTPVSRTPGSPYPSQPGAYGQYGSSDQ 1376
                               ||....:.|..:...|    ||.|    ||:|||.....|   ..|
Mouse  1338 -------------------QQQRHDSYGNQFSTQG----TPSS----SPFPSQQTTMYQ---QQQ 1372

  Fly  1377 YNATGPPGQPFGQGPGQYPPQNRNMYPPYGPEGEAPPTGANQYGPYGSRPYSQPPPGGPQPPTQT 1441
            .|...|....:|      ||..|:       |||       .|    |.|||   .|..||..|.
Mouse  1373 QNYKRPMDGTYG------PPAKRH-------EGE-------MY----SVPYS---AGQGQPQQQQ 1410

  Fly  1442 VAGGPPAGGAPGAPPSSAYPTGRPSQQDYYQPPPDQSPQPRRHPDFIKDSQPYPGYNARPQIYGA 1506
            :   |.|...|.:.|.:|.|:   .|||.|
Mouse  1411 L---PAAQSQPASQPQAAQPS---PQQDVY----------------------------------- 1434

  Fly  1507 WQSGTQQYRPQYPSSPAPQNWGGAPPRGAAPPPGAPHGPPIQQPAGVAQWDQHRYPPQQGPPPPP 1571
                 .||...||:|..           ||..         ::|||             ||
Mouse  1435 -----NQYSNAYPASAT-----------AATD---------RRPAG-------------GP---- 1457

  Fly  1572 QQQQQPQQQQQQPPYQ----QVAGPPGQQPPQ-APPQWAQMNPGQTAQSGIAPPGSPLRPPSGPG 1631
                     |.|.|:|    :|:.|||....| .|||..               |.|::..:...
Mouse  1458 ---------QNQFPFQFGRDRVSAPPGSSAQQNMPPQMM---------------GGPIQASAEVA 1498

  Fly  1632 QQNRM----PGMPAQQQQSQQQGGVPQPP--------------PQQASHGGV-PSPGL--PQVGP 1675
            ||..|    ..|.......|..|...|.|              .|:|:|.|. ||.|.  |..||
Mouse  1499 QQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGP 1563

  Fly  1676 GGMVKPPYAMPPPPSQGVGQQVGQGPPGGMMSQKPPPMPGQAMQ-------QQPLQQQPPSHQHP 1733
            ...| ||...|||.:.                |.||.||....|       .:|::.:....:.|
Mouse  1564 SAPV-PPMTRPPPSNY----------------QPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSP 1611

  Fly  1734 HPHQHPQHQHP-HQMPPNQTAPGGYGPPGMPGGGAQLVKKELIFPHDSVESTTPVLYRRKRLMKA 1797
            ..|...:.|.. ..:|.:..||....||        ::::::.||..|||:|.|||.:|:||...
Mouse  1612 FLHSGMKMQKAGPPVPASHIAPTPVQPP--------MIRRDITFPPGSVEATQPVLKQRRRLTMK 1668

  Fly  1798 DVCPVDPWRIFMAMRSGLLTECTWALDVLNVLLFDDSTVQFFGISNLPGLLTLLLEHFQKNLAEM 1862
            |:...:.||:.|:::||||.|.|||||.:|:||:||:::..|.:|.|||||.||:|:|::.|.|:
Mouse  1669 DIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEI 1733

  Fly  1863 FDERENEEQSALLAEDADDDADSGTVMCEKLRTSGRQPRCVRSISSYNRRRHYENMD----RSGK 1923
            |         .:|.|....|....|::.....|....|       ::......|::|    ...:
Mouse  1734 F---------GILKEYEVGDPGQRTLLDPGRFTKVYSP-------AHTEEEEEEHLDPKLEEEEE 1782

  Fly  1924 DGAGNGSDSEDADEGIDLGQVRVQPNPE--ERSLLLSFTPNYTMVTRKGVPVRIQPAENDIFV-- 1984
            :|.||  |.|.|..|.|      :|:.|  |..|:..|..         :||:| ...||.||
Mouse  1783 EGVGN--DEEMAFLGKD------KPSSENNEEKLVSKFDK---------LPVKI-VQRNDPFVVD 1829

  Fly  1985 --DERQKAWDIDTNRLYEQLEPVGSDAWTYGFTEPDPLDGIIDVFKSEIVNIPFARYIRSDKKGR 2047
              |:..:..:.|:..|:          |..|  ..|..:.|...|:|:|..:|...|:......|
Mouse  1830 CSDKLGRVQEFDSGLLH----------WRIG--GGDTTEHIQTHFESKIELLPSRPYVPCPTPPR 1882

  Fly  2048 KRTELASSSRKPEIKTEENSTEEQTFNKKRRLVSGGSSSSGAHAEGKKSKLTSEEFAQPNAEVKK 2112
            |.                                                ||:         |:.
Mouse  1883 KH------------------------------------------------LTT---------VEG 1890

  Fly  2113 EPGTADSDCRPVDMDIEAPQQRLTNGVAPCSSTPAIFDPRTTAKDE-ARVLQRRRDSS------- 2169
            .|||.:.:..|.|   ..|::|:|..:....||.:     :|..|| |:..:..::||
Mouse  1891 TPGTTEQEGPPPD---GLPEKRITATMDDMLSTRS-----STLTDEGAKSAEATKESSKFPFGIS 1947

  Fly  2170 ----------FEDECYTRDEASLHLVSESQDSLARRCIALSNIFRNLTFVPGNETVLAKSTRFLA 2224
                      .|||.:::||..|..:.:.|||||:||:.:||..|:|:|||||:..::|....|.
Mouse  1948 PAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLL 2012

  Fly  2225 VLGRLLLLNHEHLRRTPKTRNYDREEDTDFSDSCSSLQGEREWWWDYLITIRENMLVAMANIAGH 2289
            :||:|:||:|:|..|......|::||:.|...||..:    |||||.|..:|||.||.:|||:|.
Mouse  2013 ILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKV----EWWWDCLEMLRENTLVTLANISGQ 2073

  Fly  2290 LELSRYDELIARPLIDGLLHWAVCPSAHGQDPFPSCGPNSVLSPQRLALEALCKLCVTDANVDLV 2354
            |:||.|.|.|..|::||||||||||||..||||.:.|||:|||||||.||.|.||.:.|.||||:
Mouse  2074 LDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLI 2138

  Fly  2355 IATPPFSRLEKLCAVLTRHLCRNEDQVLREFSVNLLHYLAAADSAMARTVALQSPCISYLVAFIE 2419
            :|||||||||||.:.:.|.|...::.|.||.:|.||..||..||..||.:|:|...|..|:.|:|
Mouse  2139 LATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLE 2203

  Fly  2420 QAEQTALGVANQHGINYLRENPDSMGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMS 2484
            .:........:|..:.:: :||....||:||:||||..||.|||..:|.|.|...|.|||.:.:|
Mouse  2204 DSLAATQFQQSQASLLHM-QNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVS 2267

  Fly  2485 HILDQQVALIISRVLYQVSR 2504
            .:::..|:.:|..||:.:.:
Mouse  2268 PLMNSLVSQVICDVLFLIGQ 2287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	42/90 (47%)
		DUF3518	2191..2451	CDD:288854	125/259 (48%)
Arid1a	XP_006539388.1	DUF3498	597..>886	CDD:371844	96/344 (28%)
		ARID_ARID1A	1019..1111	CDD:350640	42/91 (46%)
		PHA03247	<1111..1665	CDD:223021	190/775 (25%)
		BAF250_C	1979..2234	CDD:371856	125/259 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846078
Domainoid	1	1.000	253	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG2510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	602	1.000	Inparanoid score	I937
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46609
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002548
OrthoInspector	1	1.000	-	-		otm43665
orthoMCL	1	0.900	-	-		OOG6_104640
Panther	1	1.100	-	-	LDO	PTHR12656
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4068
SonicParanoid	1	1.000	-	-		X2249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.920