DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and ARID5B

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	NP_115575.1	Gene:	ARID5B / 84159	HGNCID:	17362	Length:	1188	Species:	Homo sapiens

Alignment Length:	764	Identity:	155/764 - (20%)
Similarity:	239/764 - (31%)	Gaps:	278/764 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 QQSTLSNA---------SAASGEDPQCTT----------------------PKSRKNDPYSQS-- 926
            :||||::.         .|..|||.:.|.                      |.|...|.::.:
Human   147 RQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALG 211

  Fly   927 HLAPPSTSP----------HPVVMHPGGGPGEEYDMSSPPNWPRPAGSPQVFNHVPVPQEPF--- 978
            .:|..|.:|          ||.::        |.:.......|...|.|:.....|..::.|
Human   212 GIAVVSRNPQILYCRDTFDHPTLI--------ENESICDEFAPNLKGRPRKKKPCPQRRDSFSGV 268

  Fly   979 -------------------RSTITTTKKSDSLCKLYEMDDNP----------DRRGWLDKLRAFM 1014
                               ||.:|..|.:.: ||....::.|          |.:.:|..|..:|
Human   269 KDSNNNSDGKAVAKVKCEARSALTKPKNNHN-CKKVSNEEKPKVAIGEECRADEQAFLVALYKYM 332

  Fly  1015 EERRTPITACPTISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIG-ASSSAAYTLRKH 1078
            :||:|||...|.:..:.::|:.::...::.||:..:|..:.||.|...||.. .|:|||...|:|
Human   333 KERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRH 397

  Fly  1079 YTKNLLTFECHFDRGDID-PLPII---------QQVE-----AGSK-------KKTAKAASVPSP 1121
            |.:.:|.:| .|.:|:.| |||.|         |:.|     :|:|       |...:..:.|.|
Human   398 YERLILPYE-RFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKP 461

  Fly  1122 GGGHLDAGTTNSTGSSN-----SQDSFPAP-PGSAPNAAIDGYPGYPGGSPYPVAS--GPQPDYA 1178
                .||...:|.....     ||.|.|.| |.:.....|:||..:   |..|:||  .|:.|..
Human   462 ----QDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEF---SAKPLASRVDPEKDNE 519

  Fly  1179 T-----AGQMQRPPSQNNPQTPHPGAAAAVAAGDNISVSNPFEDPIAAGGGPGSGTGPGPGQGPG 1238
            |     :.::.....:..|..|.|.|                  |:|          |.......
Human   520 TDQGSNSEKVAEEAGEKGPTPPLPSA------------------PLA----------PEKDSALV 556

  Fly  1239 PGAASGGAGAVGAVGGGPQPHPPP---------------PHSPHTAAQQAAGQHQQQHPQHQHPG 1288
            |||:.             ||...|               ..||.:..|:|:           .|.
Human   557 PGASK-------------QPLTSPSALVDSKQESKLCCFTESPESEPQEAS-----------FPS 597

  Fly  1289 LPGPPPPQQQQGQQGQQPPPSVGGGPPPAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSGYPTPV 1353
            .|...||...|.:......|::                             |.|
Human   598 FPTTQPPLANQNETEDDKLPAM-----------------------------ADY----------- 622

  Fly  1354 SRTPGSPYPSQPGAYGQYGSSDQYNATGPPGQPFGQGPGQYPPQNRNMYPPYGPEGEAPPTGANQ 1418
                   ..:......|.||.|.:||       ..|.|.....|:.:|:......|   |...|.
Human   623 -------IANCTVKVDQLGSDDIHNA-------LKQTPKVLVVQSFDMFKDKDLTG---PMNENH 670

  Fly  1419 YGPYGSRPYSQPPPGGPQPPTQTVAGGPPAGGAPGAPPSSAYPTGRPSQQDYYQPPPDQSPQPRR 1483
            ...|....||:..||...|    :|.........||..||:||.|.|       ||.....:...
Human   671 GLNYTPLLYSRGNPGIMSP----LAKKKLLSQVSGASLSSSYPYGSP-------PPLISKKKLIA 724

  Fly  1484 HPDFIKD-SQPYPGYN------ARPQIYGAWQSGTQQYRPQYPSSPAPQ 1525
            ..|.... ||.:.|.:      :||.:.        |:...:.|.|:.:
Human   725 RDDLCSSLSQTHHGQSTDHMAVSRPSVI--------QHVQSFRSKPSEE 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	30/101 (30%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
ARID5B	NP_115575.1	BAH	34..>108	CDD:295389
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..277		3/25 (12%)
		BRIGHT	319..411	CDD:128777	29/92 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..611		53/257 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..874
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..918
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..978
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1070
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940