DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osa and Arid5b

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	XP_006514192.1	Gene:	Arid5b / 71371	MGIID:	2175912	Length:	1214	Species:	Mus musculus

Alignment Length:	853	Identity:	172/853 - (20%)
Similarity:	259/853 - (30%)	Gaps:	300/853 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 GSPTPPQGPQGYGNGPTGMHPGMPMGPPHHMGPPHGPTNMGPPTSTPPQSQMLQGGQPQGQGASG 847
            |||           ||.....|:.:.|.|.....|..|:....|.|...:..:.|....|:|...
Mouse    29 GSP-----------GPRAELGGVIVTPLHTHTHTHTHTHTHTHTHTHTHTGTILGSLRPGRGGRE 82

  Fly   848 GPESGG-----PEHISQDNGI-------SSSGPTGAA---------------------------- 872
            |....|     |.   |...|       :||.|...|
Mouse    83 GARPPGQALCLPR---QSRVIRLRLLRAASSAPGSRAFEDEVIAVSEKVIVKLEDLVKWAHSDFS 144

  Fly   873 ----GMHAVTSVVTTGPDGTSMDEV---SQQSTLSNA---------SAASGEDPQCTT------- 914
                |:.| |.|.|.........|.   .:||||::.         .|..|||.:.|.
Mouse   145 KWRCGLRA-TPVKTEAFGRNGQKEALLRYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYP 208

  Fly   915 ---------------PKSRKNDPYSQS--HLAPPSTSP----------HPVVMHPGGGPGEEYDM 952
                           |.|...|.::.:  .:|..|.:|          ||.::        |.:.
Mouse   209 QYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLI--------ENES 265

  Fly   953 SSPPNWPRPAGSPQVFNHVPVPQEPF----------------------RSTITTTKKSDSLCKLY 995
            ......|...|.|:.....|..::.|                      ||.:|..|.:.:.||..
Mouse   266 VCDEFAPNLKGRPRKKKTCPQRRDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKNNHNNCKKT 330

  Fly   996 EMDDNP----------DRRGWLDKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEV 1050
            ..::.|          |.:.:|..|..:|:||:|||...|.:..:.::|:.::...::.||:..:
Mouse   331 SNEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETI 395

  Fly  1051 TKSKTWKDIAGLLGIG-ASSSAAYTLRKHYTKNLLTFECHFDRGDID-PLPII--QQVEAGSKKK 1111
            |..:.||.|...||.. .|:|||...|:||.:.:|.:| .|.:|:.| |||.|  ::.|..:::.
Mouse   396 TARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYE-RFIKGEEDKPLPPIKPRKQENNTQEN 459

  Fly  1112 TAKAASVPSPGGGHLDAGTTNSTGSSNSQDSFPAPPGSAPNAAIDGYPGYPGGSPYPVASGPQP- 1175
            ..|                |..:|:...:...........|.                   |:|
Mouse   460 ENK----------------TKVSGNKRIKQEMAKNKKEKENT-------------------PKPQ 489

  Fly  1176 DYATAGQMQRPPSQ--NNPQTPHPGAAAAVAAGDNISVSNPFEDPIAAGGGPGSGTGPGPGQGPG 1238
            |.:.....||...:  |:...|.|..|..|                               :|..
Mouse   490 DTSEVSSEQRKEEETLNHKSAPEPLPAPEV-------------------------------KGKP 523

  Fly  1239 PGAASGGAGAVGAVGGGPQPHPPPPHSPHTAAQQAAGQHQQQHPQHQ-----HPGLPGPP-PPQQ 1297
            .|....||.|           |.....|..|.:...|.:.::..:..     .|.||.|| ||::
Mouse   524 EGHKDLGARA-----------PVSRADPEKANETDQGSNSEKEAEEMGDKGLAPLLPSPPLPPEK 577

  Fly  1298 QQGQQGQQPPPSVGGGP--PPAPQQHGPGQVPP-----SPQQHVRPAAGAPYPPGGSGYPTPVSR 1355
            ...     |.|..|..|  .|:.|.....:..|     ||::.::   |||:....:..|
Mouse   578 DSA-----PTPGAGKQPLASPSTQMDSKQEAKPCCFTESPEKDLQ---GAPFSSFSATKP----- 629

  Fly  1356 TPGSPYPSQPGA------------------YGQYGSSDQYNATGPPGQPFGQGPGQYPPQNRNMY 1402
                |..||..|                  ..|.||.|.:.|       ..|.|.....|:.:|:
Mouse   630 ----PLTSQNEAEEEQLPATANYIANCTVKVDQLGSDDIHTA-------LKQTPKVLVVQSFDMF 683

  Fly  1403 PPYGPEGEAPPTGANQYGPYGSRPYSQPPPGGPQPPTQTVAGGPPAGGAPGAPPSSAYPTGRPSQ 1467
            ......|   |...|....|....||:..||...|    :|.........||..||:||
Mouse   684 KDKDLTG---PMNENHGLNYTPLLYSRGNPGIMSP----LAKKKLLSQVSGASLSSSYP------ 735

  Fly  1468 QDYYQPPP 1475
              |..|||
Mouse   736 --YGSPPP 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	30/101 (30%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
Arid5b	XP_006514192.1	PTZ00121	<437..>562	CDD:173412	30/201 (15%)
Arid5b	XP_006514192.1	ARID_ARID5B	347..441	CDD:350649	30/94 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940