DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and ARID1B

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	NP_001361757.1	Gene:	ARID1B / 57492	HGNCID:	18040	Length:	2372	Species:	Homo sapiens

Alignment Length:	2931	Identity:	781/2931 - (26%)
Similarity:	1057/2931 - (36%)	Gaps:	1031/2931 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GGAPAPAATPPSAGAAPGAATPPTSGPPTPNNNSNNGS------DPSIQQQQQNVAPHPYGAPPP 74
            |..|||.|....|||...||.....||.........|.      .|.:.:.:.|:| |..||...
Human    30 GPRPAPGARDLEAGARGAAAAAAAPGPMLGGGGDGGGGLNSVHHHPLLPRHELNMA-HNAGAAAA 93

  Fly    75 PG----------------------------------------SGPGG-------------PPGPD 86
            .|                                        ||||.             ..|..
Human    94 AGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEA 158

  Fly    87 PAAVMHY---------------HHLH-------------------------QQQQQHP------- 104
            |||..|.               ||||                         |||||||
Human   159 PAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSL 223

  Fly   105 ---------PPPHMQQQQHHG-------------GP-----------APP----PPGGAPEHAPG 132
                     |.|.|:|.||.|             ||           |||    |.||..|| ||
Human   224 GGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEH-PG 287

  Fly   133 VKEEYTHLPP---------PHPHPAYGRYH-------------ADPNMDPYRYGQPLPG------ 169
            :....|..||         |...|.:..|:             |.|..|.:. ||..||
Human   288 LGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHG-GQQSPGMGMMHS 351

  Fly   170 ------GKP----PQQ--QQPHPQQQ--------------------------------------- 183
                  |.|    |.|  .:.:|..|
Human   352 ASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGG 416

  Fly   184 -------------------------------------PPQQ-------PGPGGSPNRPPQ----- 199
                                                 |.||       ||.||:.:....
Human   417 AGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSA 481

  Fly   200 ----QRYI-PGQPPQGPTPTLNSLLQS------------------SNPPPPPQHRYANTYDPQQA 241
                ||:. ..|.|.|.|||||.||.|                  |.|||||.       .||..
Human   482 AGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPS-------QPQSQ 539

  Fly   242 AASAAAAAAAQQQQAGGPPPPGHGPPPPQHQPSPYGGQQGGWAPPPRPYSPQLGPSQQYRTPPPT 306
            ||:|.|||..||..||    .|.|    :...:.|......||...:...|.:.|.    ||.||
Human   540 AAAAGAAAGGQQAAAG----MGLG----KDMGAQYAAASPAWAAAQQRSHPAMSPG----TPGPT 592

  Fly   307 NTSRGQSPYPPAHGQNSGSYPSSPQQQQQQQ--------QQQQQQAGQQPGGPVPGGPP------ 357
                        .|::.|| |..|...::.|        ..|.||:...|||..  |||
Human   593 ------------MGRSQGS-PMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSY--GPPGPQRYP 642

  Fly   358 -------PG--TGQQPPQQNTPPTSQY-------------SPYPQRYPTPPGLPAGGSNHRTAYS 400
                   ||  .|.|.|||..||  ||             .||..:.|.||.||. .:.:..:.|
Human   643 IGIQGRTPGAMAGMQYPQQQMPP--QYGQQGVSGYCQQGQQPYYSQQPQPPHLPP-QAQYLPSQS 704

  Fly   401 THQY-PEPNRPWPG-GSSPSPGSGHPLPPASPHH--VPPLQQQPPP------------------- 442
            ..:| |:.:....| |:...|    ||.|..|:|  :..:||:.|.
Human   705 QQRYQPQQDMSQEGYGTRSQP----PLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEAT 765

  Fly   443 -PPHVSAGGPPPSSSPGHAPSPSPQPSQASPSPHQELIGQNSNDSSSGGAHSGMGSGPPGTPNPQ 506
             ...|||.|  .:||.|...:|:..|.....|||...|                    ||.|:|.
Human   766 LSSAVSASG--STSSQGDQSNPAQSPFSPHASPHLSSI--------------------PGGPSPS 808

  Fly   507 QVMRPTPSPTGSSGSRSMSPAVAQNHPISRPASNQSSSGGPMQQPPVGAGGPPPMPPHPGMPGGP 571
                |..||.||:.|||        .||| |||...|     |.||...|.......||.:...|
Human   809 ----PVGSPVGSNQSRS--------GPIS-PASIPGS-----QMPPQPPGSQSESSSHPALSQSP 855

  Fly   572 PQQQQSQQQQASNSASSASNSPQQTPPPAPPPNQGMNNMATPPPPPQGAAGGGYPMPPHMHGGYK 636
            ..|::........:...|...||||.|           ..:|.|.|.|          .||.|..
Human   856 MPQERGFMAGTQRNPQMAQYGPQQTGP-----------SMSPHPSPGG----------QMHAGIS 899

  Fly   637 MGGPGQSPGAQGYPPQQPQQYPPGNYPPRPQYP--PGAYATGPPPPPTSQAG---AGGANSMPSG 696
            ......|.|.  |.||..|..|.|||...|.|.  |.|..:||.|.....|.   .|...|.|.|
Human   900 SFQQSNSSGT--YGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCG 962

  Fly   697 A-QAGGYPGRGMPNHTGQYPPYQWVPPSPQQTVPGGAPGGAMVGNHVQGKGTPPPPVVGGPPPPQ 760
            | ..|..|..||.|.     |:    |....::...:||.:.               .|||
Human   963 AVPLGRMPSAGMQNR-----PF----PGNMSSMTPSSPGMSQ---------------QGGP---- 999

  Fly   761 GSGSPRP-LNYLKQHLQHKGGYGGSPTPPQGPQGYGNGPTGMHPGMPMGPPHHMGPPHGPTNMGP 824
            |.|.|.| :|...|.        .:....|..........|..|||              ...|.
Human  1000 GMGPPMPTVNRKAQE--------AAAAVMQAAANSAQSRQGSFPGM--------------NQSGL 1042

  Fly   825 PTSTPPQSQMLQGGQPQGQGAS-----GGPESGGPEHISQDNGISSSGPTGAAGMHAVTSVVTTG 884
            ..|:.|.|      ||....:|     ..|.|..|..::     ||:...|.|.|      ::.|
Human  1043 MASSSPYS------QPMNNSSSLMNTQAPPYSMAPAMVN-----SSAASVGLADM------MSPG 1090

  Fly   885 PDGTSMDEVSQQSTLSNASAASGEDPQCTTPKSRKNDPYSQSHLAPPSTS---PHPVVMHPGGGP 946
                       :|.|.....|.|::.....|:|:..|.||...::.|.|.   |.|..|.|....
Human  1091 -----------ESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSAS 1144

  Fly   947 -----GEEYDMSSPPNWPRPAGSPQVFNHVPVPQEPFRSTITTTKKSDSLCKLYEMDDNPDRRGW 1006
                 |:|.|..|.|.||:            .|..|..|:.|||  .:.:.|:||:.:.|:|:.|
Human  1145 ISSFHGDESDSISSPGWPK------------TPSSPKSSSSTTT--GEKITKVYELGNEPERKLW 1195

  Fly  1007 LDKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGASSSA 1071
            :|:...|||||.:|:::.|.:.|:||||:|||:.|||.||..:|.|:|.|:::|..|.:|.||||
Human  1196 VDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSA 1260

  Fly  1072 AYTLRKHYTKNLLTFECHFDRGDIDPLPIIQQVEAGSKKKTAKAASVPSP-GGGHLDAGTTNSTG 1135
            |.:|:|.|.:.|..|||..:||: :|.|  :....|..||..| ...||| ..|.|....|..:.
Human  1261 ASSLKKQYIQYLFAFECKIERGE-EPPP--EVFSTGDTKKQPK-LQPPSPANSGSLQGPQTPQST 1321

  Fly  1136 SSNSQDSFPAPPGSAPNAAIDGYPGYPGGSPYPVASGPQPDYATAGQMQRPPSQNNPQTPHPGAA 1200
            .|||....|.          |..|..|..:|:             |||          ||..|..
Human  1322 GSNSMAEVPG----------DLKPPTPASTPH-------------GQM----------TPMQGGR 1353

  Fly  1201 AAVAAGDNISVSNPFEDPIAAGGGPGSGTGPGPGQGPGPGAASGGAGAVGAVGGGPQPHPPPPHS 1265
            ::     .|||.:||.|.                                :....|:.:...|::
Human  1354 SS-----TISVHDPFSDV--------------------------------SDSSFPKRNSMTPNA 1381

  Fly  1266 PHTAAQQAAGQHQQQHPQHQHPGLPGPPPPQQQQGQQGQQPPPSVGGGPPPAPQQHGPGQVPPSP 1330
            |:                                 |||...|..:             |::|..|
Human  1382 PY---------------------------------QQGMSMPDVM-------------GRMPYEP 1400

  Fly  1331 QQHVRPAAGAPYPPGGSGYPTPVSRTPGS--PYPSQPGAYGQYGSS---DQYNATGPPGQPFGQG 1390
            .:.         |.||      :.:.|||  |:.:|    ||..:|   |.||.: |.|.....|
Human  1401 NKD---------PFGG------MRKVPGSSEPFMTQ----GQMPNSSMQDMYNQS-PSGAMSNLG 1445

  Fly  1391 PGQYPPQNRNMYP----------PYGPE--GEAPPTGANQYGPYGSRPYSQPPPGGPQP---PTQ 1440
            .||     |..:|          |||.:  |:.||:|             |||.||.||   |.|
Human  1446 MGQ-----RQQFPYGASYDRRHEPYGQQYPGQGPPSG-------------QPPYGGHQPGLYPQQ 1492

  Fly  1441 T-----VAG--GPPAGGAPGAPPSSAYPTGRPSQQDYYQPPPDQSPQPRRHPDFIKDSQPYPGYN 1498
            .     :.|  ||||....|...:..|.:   .||:.|.........|.|.|  |:...|||  .
Human  1493 PNYKRHMDGMYGPPAKRHEGDMYNMQYSS---QQQEMYNQYGGSYSGPDRRP--IQGQYPYP--Y 1550

  Fly  1499 ARPQIYGAWQSGTQQYRPQYPSSPAPQNWGGAPPRGAAPPPGAPHGPPIQQPAGVAQWDQHRYPP 1563
            :|.::.|..|..|                               ||.|.|...|         |.
Human  1551 SRERMQGPGQIQT-------------------------------HGIPPQMMGG---------PL 1575

  Fly  1564 QQGPPPPPQQQQQPQQQQQQPPYQQVAGPPGQQPPQAPPQWAQMNPGQTAQSGIAPPGSPLRPPS 1628
            |......|||.....:.....|||...||.|  |.||||.
Human  1576 QSSSSEGPQQNMWAARNDMPYPYQNRQGPGG--PTQAPPY------------------------- 1613

  Fly  1629 GPGQQNRMPGMPAQQQ----QSQQQGGVPQPPPQQASHGGVPSPGLPQVGPGGMVKPPYAMPPPP 1689
             || .||...|....|    :||....|.|..|..:|...:               .|...||.|
Human  1614 -PG-MNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASM---------------QPITRPPQP 1661

  Fly  1690 SQGVGQQVGQGPPG--GMMSQKPPPMPGQAMQQQPLQQQPPSHQHPH-PHQHPQHQHPHQMPPNQ 1751
            |.       |.||.  ..:|:.|.|    |..|:.|:.:....:.|. |....|...| .:|.:|
Human  1662 SY-------QTPPSLPNHISRAPSP----ASFQRSLENRMSPSKSPFLPSMKMQKVMP-TVPTSQ 1714

  Fly  1752 TAPGGYGPPGMPGGGAQLVKKELIFPHDSVESTTPVLYRRKRLMKADVCPVDPWRIFMAMRSGLL 1816
            ..    |||..|    ..:::|:.||..|||::.|||.:|:::...|:...:.||:.|:::||||
Human  1715 VT----GPPPQP----PPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLL 1771

  Fly  1817 TECTWALDVLNVLLFDDSTVQFFGISNLPGLLTLLLEHFQKNLAEMFD----------------- 1864
            .|.|||||.:|:||:|||||..|.:|.|.|.|.||:|:|:|.|.::|.
Human  1772 AESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDH 1836

  Fly  1865 --ERENEEQSALLAEDA---DDDADSGTVMCEKLRTSGRQPRCVRSISSYNRRRHYENMDRSGKD 1924
              .|:::.||  ||:|:   ::||:                 |:               |...:|
Human  1837 NAARKDDSQS--LADDSGKEEEDAE-----------------CI---------------DDDEED 1867

  Fly  1925 GAGNGSDSE--DADE--GIDLGQVRVQPNPEERSLLLSFTPNYTMVTRKGVPVRIQPAENDIFVD 1985
            ......|||  ::||  .|.|.......:|:|:       |.......| :|::| ..:|::||.
Human  1868 EEDEEEDSEKTESDEKSSIALTAPDAAADPKEK-------PKQASKFDK-LPIKI-VKKNNLFVV 1923

  Fly  1986 ERQ----KAWDIDTNRLYEQLEPVGSDAWTYGFTEPDPLDGIIDVFKSEIVNIPFARYIRSDKKG 2046
            :|.    :..:.::..|:.||.  |.|.                   :|.:...|...:....:.
Human  1924 DRSDKLGRVQEFNSGLLHWQLG--GGDT-------------------TEHIQTHFESKMEIPPRR 1967

  Fly  2047 RKRTELASSSRKPEIKTEENSTEEQTFNKKRRLVSGGSSSSGAHAEGKKSKLTSEEFAQPNAEVK 2111
            |....|:|:.||.|.:.:.:|.|:|                      :||.:     |..:..:.
Human  1968 RPPPPLSSAGRKKEQEGKGDSEEQQ----------------------EKSII-----ATIDDVLS 2005

  Fly  2112 KEPGTADSDCRPVDMDIEAPQ---QRLTNGVAPCSSTPAIFDPRTTAKDEARVLQRRRDSSFEDE 2173
            ..||....|..|      .||   .:...|:....|                   .|.....|||
Human  2006 ARPGALPEDANP------GPQTESSKFPFGIQQAKS-------------------HRNIKLLEDE 2045

  Fly  2174 CYTRDEASLHLVSESQDSLARRCIALSNIFRNLTFVPGNETVLAKSTRFLAVLGRLLLLNHEHLR 2238
            ..:|||..|..::..|||||:|||.:|||.|:|:|||||:..::|....:.:||:|:||:|||..
Human  2046 PRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE 2110

  Fly  2239 RTPKTRNYDREEDTDFSDSCSSLQGEREWWWDYLITIRENMLVAMANIAGHLELSRYDELIARPL 2303
            |....:.|::|||.|...:||    :.|||||.|..:|:|.||.:|||:|.|:||.|.|.|..|:
Human  2111 RKRAPQTYEKEEDEDKGVACS----KDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPI 2171

  Fly  2304 IDGLLHWAVCPSAHGQDPFPSCGPNSVLSPQRLALEALCKLCVTDANVDLVIATPPFSRLEKLCA 2368
            :||||||.|||||..|||||:.|||||||||||.||.||||.:.|.||||::|||||||.||..|
Human  2172 LDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYA 2236

  Fly  2369 VLTRHLCRNEDQVLREFSVNLLHYLAAADSAMARTVALQSPCISYLVAFIEQAEQTALGVANQHG 2433
            .|.|::...::.|.||.|:.||..||..|:..||.:|:|...|..|::|:|.....|....:||.
Human  2237 TLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHN 2301

  Fly  2434 INYLRENPDSMGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMSHILDQQVALIISRV 2498
            :.:: :.|.....|:||:.|||..||.:|:..:|||.|:..|.|||.:.:|.:|:..||.:|..|
Human  2302 LMHM-QPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDV 2365

  Fly  2499 LYQVSR 2504
            |:|:.:
Human  2366 LFQIGQ 2371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	43/90 (48%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854	127/259 (49%)
ARID1B	NP_001361757.1	PRK10263	<756..>944	CDD:236669	70/250 (28%)
		Atrophin-1	773..>1128	CDD:367360	122/495 (25%)
		ARID_ARID1B	1190..1282	CDD:350641	43/91 (47%)
		Med15	1303..>1683	CDD:312941	139/635 (22%)
		BAF250_C	2063..2318	CDD:371856	127/259 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155641
Domainoid	1	1.000	253	1.000	Domainoid score	I2082
eggNOG	1	0.900	-	-		E1_KOG2510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	634	1.000	Inparanoid score	I836
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46609
OrthoDB	1	1.010	-	-		D135670at33208
OrthoFinder	1	1.000	-	-		FOG0002548
OrthoInspector	1	1.000	-	-		otm41619
orthoMCL	1	0.900	-	-		OOG6_104640
Panther	1	1.100	-	-	O	PTHR12656
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4068
SonicParanoid	1	1.000	-	-		X2249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.930