DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and arid3b

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	XP_005163185.1	Gene:	arid3b / 571249	ZFINID:	ZDB-GENE-070209-182	Length:	616	Species:	Danio rerio

Alignment Length:	674	Identity:	154/674 - (22%)
Similarity:	230/674 - (34%)	Gaps:	205/674 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   804 GMPMGPPHHMGPPHGPTNMGPPTSTPPQSQMLQGGQPQGQGASGGP----------ESGGPEHIS 858
            |.|:.|..:              |...:.:.|:||  ||..|:.||          |....|
Zfish    87 GAPLTPDFY--------------SKNSRDRALKGG--QGPLAARGPVKTASDLAHEEDAADE--- 132

  Fly   859 QDNGISSSGPTGAAGMHAVTSVVTTGPDGTSMDEVS-----QQSTLSNASAASGEDP-----QCT 913
            .|.|      .|:.|.......:..|.||:..:|..     ::.:|:...||.|..|     ...
Zfish   133 MDRG------RGSEGDEDDDDEMMDGEDGSEEEESEGLEFLRKQSLALQQAAVGVPPYSFPVYTA 191

  Fly   914 TPKSRKNDPYSQSHLAPPSTSPHPVVMHPGGGPGEEYDMSSP---PNWPRPAGSPQVFNHVPVPQ 975
            :|.:.|..|.|      |:|.   |...|.....::...::|   .:|..              .
Zfish   192 SPSAAKKRPLS------PTTK---VKDEPEDSLSDQQSFNTPNGMGDWNL--------------D 233

  Fly   976 EPFRSTITTT------------KKSDSLCKLYEMDDNPDRRGWLDKLRAFMEERRTPITACPTIS 1028
            :.|:....::            :.|....||||:|::|.|:.:||.|.|:|::|.||:...|.::
Zfish   234 DSFKQNGNSSWNEEGDGGRSRGEASRDFAKLYELDNDPKRKEFLDDLFAYMQKRGTPVNRIPIMA 298

  Fly  1029 KQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGAS-SSAAYTLRKHYTKNLLTFECHFDR 1092
            ||.||||.||..|.|:||.|||...|.|::|...|.:..| :|||:|||..|.|.|..:||
Zfish   299 KQVLDLYMLYKLVTEKGGLVEVINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYPYEC---- 359

  Fly  1093 GDIDPLPIIQQVEAGSKKKTAKAASVPSPGGGHLDAGTTNS------TGSSNSQDSF-PAPPGSA 1150
                            :||     .:.||  |.|.|...::      .|.|||...| |:|.|:|
Zfish   360 ----------------EKK-----GLSSP--GELQAAIDSNRREGRRPGYSNSLYRFSPSPSGAA 401

  Fly  1151 PNAAIDGYPGYPGGSPYPVASGPQPDYATAGQMQRPPSQNN--PQTPHPGAAAAVAAGDNISVSN 1213
            |:                :.|.|        :|..|.:.:|  ..||.|....|....|:.:...
Zfish   402 PH----------------LLSPP--------KMHLPATGHNELQATPSPALKKATVPEDSPASML 442

  Fly  1214 PFEDPIAAGGGPGSGTGPGPGQGPGPGAAS---------GGAGAVGAVGGGPQPHPPPPHSPHTA 1269
            |...|:|...|         .|.....||:         .|.|| |||..||.....|.......
Zfish   443 PARLPLALALG---------HQQQLARAATLEQLRERLETGMGA-GAVNAGPAVVEGPERKMARL 497

  Fly  1270 AQQAAGQHQQQHPQHQHPGLPGPPPPQQQQG-----QQGQQPPPSVGGGPPPAPQQHGPGQVPPS 1329
            |::.....||...|:.........|...:..     ::.|....|:        ..:|...:..|
Zfish   498 AEEQQRLLQQAFQQNLLAMASQVNPTNLRMNNANTREEKQDLSLSI--------SSNGSASITVS 554

  Fly  1330 PQQHVRPAAGAPYPPGGSGYPTPVSRT-PGSPYPSQPGAYGQYGSSDQYNATGPPGQPFGQGPGQ 1393
            .:.:....:|:.|.......||.|:.. ||......||......||..
Zfish   555 VEVNGIIYSGSLYAQKSGSVPTAVTAMFPGHTSTLSPGVASSSSSSSS----------------- 602

  Fly  1394 YPPQNRNMYPPYGPEGEAPPTGAN 1417
                       .||:...|.||.:
Zfish   603 -----------KGPDSVDPATGGS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	42/91 (46%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
arid3b	XP_005163185.1	BRIGHT	271..363	CDD:128777	44/116 (38%)
arid3b	XP_005163185.1	DUF4251	<523..566	CDD:290766	5/50 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940