DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and arid1b

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	XP_005160411.1	Gene:	arid1b / 569589	ZFINID:	ZDB-GENE-030131-4459	Length:	2170	Species:	Danio rerio

Alignment Length:	2630	Identity:	752/2630 - (28%)
Similarity:	1003/2630 - (38%)	Gaps:	737/2630 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GPPTPNNNSNN---GSDPSIQQQQQNVAP--HPYGAPPPPGSGPGGPPGPDPAAVMHYHHLHQQQ 100
            ||.:.|||:||   |...:.|....:|:.  :.|      |:|.|||        ....|..||.
Zfish   111 GPASNNNNNNNSGGGGGSASQSGSSSVSEFNNYY------GNGRGGP--------CFDQHGGQQS 161

  Fly   101 QQ----HPPPPHMQQQQ-----HHGGPAPPPPGGAPEHAPGVKEEYTHLP---PPHPHPAYGRYH 153
            .:    |..|.:|.|.|     :|..|                  |.|.|   |.:....||.
Zfish   162 PRTALIHQAPGNMDQVQNSHEGYHNNP------------------YNHYPNYRPGYGGAGYGM-- 206

  Fly   154 ADPNMDPYRYGQPL-PG-GKPPQQQQPHPQ-QQPPQQPGPG---GSPNRPPQQRYIPGQPPQGPT 212
                |.|.|.|..: || ..|......|.: ......|.||   ||..|.|.|..   |.|.|.|
Zfish   207 ----MSPSRQGNMMGPGTNSPTAAAASHGKAAMASTTPAPGANVGSFQRFPGQNQ---QHPSGAT 264

  Fly   213 PTLNSLLQSSNPPPPPQHRYANTYDPQQAAASAAAAAAAQQQQAGGPPPPGHGPPPPQHQPSPYG 277
            ||||.||.|   |.|....|...|.......|       ||||:|    .|.|    :...|||.
Zfish   265 PTLNQLLTS---PSPMMRGYGGGYQDYSNPPS-------QQQQSG----MGLG----KDMSSPYS 311

  Fly   278 -GQQGGWAPPPRPYSPQLGPSQ------QYRTPPPTNTSR------GQSPY-------------P 316
             .....||...|.: |.:.|..      |..|..|....|      |.:||             |
Zfish   312 PAASHSWAAQQRNH-PAMSPGNNGNSRAQVATMDPMTMKRSQMYGMGNNPYSQQGTYAGQPYGSP 375

  Fly   317 PAHG-----QNSGSYPSSPQQQQQQQQQQQQQAGQQPGGPVPGGPPPGTGQQPPQQNTPPTSQYS 376
            .||.     |..|.......|..||||...|...|...|....|.||..  .||||.:...|| .
Zfish   376 TAHRYPMGMQGRGQVGIGGMQYSQQQQMPAQYGPQGMSGYCQQGQPPYF--SPPQQQSAAPSQ-P 437

  Fly   377 PY-PQRYPTPPGL---------PAGGSNHRTAYSTHQYPEPNRPWPGGSSPS-PGSGHPLPPASP 430
            || .||.||....         .:|..||.....|.|    :||   .|.|. .||...||..:.
Zfish   438 PYMQQRAPTQQDTLQEGYGSRGQSGKPNHDDMGLTQQ----DRP---SSLPDLSGSIDDLPTGTE 495

  Fly   431 HHVPPLQQQPPPPPHVSAGGPPPSSSPGHAPSPSPQPSQASPSPHQELIGQNSNDSSSGGAHSGM 495
            ..:...         |||.|  .:||.|...:|:..|.....||..                ..|
Zfish   496 AGLSSA---------VSASG--STSSQGEQSNPAQSPFSPHASPRV----------------PSM 533

  Fly   496 GSGPPGTPNPQQVMRPTPSPTGSSGSRSMSPAVAQNHPISRPASNQSSSGGP-MQQPPVGAGGPP 559
            .|||  :|:      |..||.|||.|||        .||| |||      || .|..|...|..|
Zfish   534 RSGP--SPS------PVGSPVGSSQSRS--------GPIS-PAS------GPGTQMAPQTPGNVP 575

  Fly   560 PMPPHPGMPGGPPQQQQSQQQQASNSASSASNSP--QQTPPPAPPPNQGMNNMATPPPPPQGAAG 622
            .:..|......|..|::.   .|||...:|..|.  .|.|.|:..|:.          .|.|
Zfish   576 DVGSHSTHSQSPMSQERG---YASNMQRNAPGSQFGGQQPGPSMSPHS----------CPTG--- 624

  Fly   623 GGYPMPPHMHGGYKMGGPGQSPGAQGYPPQQPQQYPPGNYPPRPQY--PPGAYATGPPPPPTSQA 685
               || .|..|.|:||        ..|.||..|..|.||||....|  .|||..:||.|
Zfish   625 ---PM-HHSVGSYQMG--------PSYGPQSGQYGPSGNYPRPANYGGAPGANYSGPGP------ 671

  Fly   686 GAG---GAN-SMPSGAQAGGYP------GRGMPNHTGQYPPYQWVPPSPQQTVPGGAPGGAMVGN 740
            |.|   |.| |.|...|..|.|      .|| |.|.....||    |:...:|...:|      |
Zfish   672 GMGNSLGMNASSPMHGQGPGQPCGSMTTARG-PGHAAGGRPY----PAGSSSVAPTSP------N 725

  Fly   741 HVQGKGT---PPPPVVGGPPPPQGSGSPRPLNYLKQHL----QHKGGYGGSPTPPQGPQGYG-NG 797
            ..|..|.   ||||.||..|...|..|      .:|:|    |.:..:|.||..|      | :|
Zfish   726 MPQSAGPGMGPPPPNVGRKPHESGPAS------AQQNLVPSSQARPPFGRSPVYP------GLSG 778

  Fly   798 PTGMHP-GMPMGPPHHMGPPHGPTNMGPPTSTPPQSQMLQGGQPQGQ-----GASGGPE-----S 851
            |.|..| ...:..|||   ||..:..|.             |||..:     |..||..     .
Zfish   779 PGGRPPASFSLPQPHH---PHYSSGQGQ-------------GQPHAELYGPAGYQGGSHMLGMGP 827

  Fly   852 GGPEHISQDNGISSSGPTGAAGMHAVTSVVTTGPDGTSMDEVSQQSTLSNAS-AASGEDPQCTTP 915
            |||..:...|..:...|.|.:     .:.:.|||...|.|.:........|. ...|..|....|
Zfish   828 GGPYSLPPSNSSARMTPQGPS-----YNTMPTGPMTGSGDTMMPTDPKQRAEHKEEGSTPATEPP 887

  Fly   916 KSRKNDPY-SQSHLAPPSTSP-HPVVMHPGGGPGEEYDMSSPPNWPRPAGSPQVFNHVPVPQEPF 978
            |.:.|  | ||....||:.|| .|.........|::.|..|.|.||:.            |..|.
Zfish   888 KPKDN--YGSQCVSQPPTPSPLSPSPASLSSYQGDDSDSISSPAWPKN------------PSSPK 938

  Fly   979 RSTITTTKKSDSLCKLYEMDDNPDRRGWLDKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKE 1043
            .||:..|  ::.:.:||:|...|:||.|:|:..||||||.||:...|::.|:||||.|||:.|:|
Zfish   939 HSTVNMT--NEKITRLYDMGCEPERRAWVDRYIAFMEERGTPVPNLPSVGKKPLDLCRLYLCVRE 1001

  Fly  1044 RGGFVEVTKSKTWKDIAGLLGIGASSSAAYTLRKHYTKNLLTFECHFDRGDIDPLPIIQQVEAGS 1108
            .||...|.|:|.|::::..|.:|.|||:|.:|:|.|.:.|..:||..:||: :|.|....:..|.
Zfish  1002 IGGLAMVNKNKKWRELSTHLNVGTSSSSASSLKKQYIQYLFAYECKVERGE-EPPPDAFAMGDGK 1065

  Fly  1109 KKKTAKAASVPSP-GGGHLDA-GTTNSTGSSNSQ----DSFPAPPGSAPNAAIDGYPGYPGGS-- 1165
            |::.......||| ..|.|.. .|..|||||...    |..|..|.:.|:..:...|......
Zfish  1066 KQQQQAKIQPPSPANSGSLQGPQTPQSTGSSTMTEMPGDLKPPTPATTPHGQVTPQPAVRNSGIS 1130

  Fly  1166 -PYPVASGPQPDYATAGQMQRPPSQNNPQTPHPGAAAAVAAGDNISVSNPFEDPIAAGGGPGSGT 1229
             ..|.:.|..|.:...|.|            |.|:..|.:.....:..:||  ..|..||..|..
Zfish  1131 VQDPFSEGSDPAFQKRGPM------------HGGSGDATSRMQFDTSKDPF--GAARKGGSESFV 1181

  Fly  1230 GPGPGQGPGPGAAS-GGAGAVGAVGGGPQPHPPPPHSPHTAAQQAAGQHQQQHPQHQHPGLPGPP 1293
               |||.||.|... ...|....:|.||:|            |.:.....::.|.|    :.||.
Zfish  1182 ---PGQMPGSGMQEMYSRGPSSGMGMGPRP------------QYSYNPGFERRPDH----VMGPE 1227

  Fly  1294 PPQQQQGQQGQQPP----PSVGGGPPPAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSGYPTPVS 1354
            ......|.|....|    ||:..|...|..|          .:|           |..||
Zfish  1228 GGIAASGNQNNMVPSSSDPSMFSGSRYASHQ----------SRH-----------GHDGY----- 1266

  Fly  1355 RTPGSPYP-SQP-GAYGQYGSSDQYNATGPPGQPFGQGPGQY-PPQNRNMYPPYGPE-GEAPPTG 1415
               |..|| |.| ||:|.|.....|..   ||:      |.| ||..|:....||.: |...|..
Zfish  1267 ---GQQYPHSMPYGAHGMYPQQQGYKR---PGE------GMYGPPAKRHESEAYGMQYGGQQPDM 1319

  Fly  1416 ANQYGPYGSRPYSQP----------PPGGPQPPTQTVAGG--PPAGGAPGAPPSSAYPTGRPSQQ 1468
            .:|||....||...|          .|||..||..::..|  ||:..:.|.|..:.:.|
Zfish  1320 YSQYGYPERRPMQSPFPYGYGRDRMQPGGQGPPQHSMMSGGPPPSSNSSGGPQGNMWHT------ 1378

  Fly  1469 DYYQPPPDQSPQPRRHPDFIKDSQPYPGYNARPQIYGAWQSGTQQYRPQYPSSPAPQNWGGAPPR 1533
                          || |.   :.|||               |:|
Zfish  1379 --------------RH-DM---AYPYP---------------TRQ-------------------- 1390

  Fly  1534 GAAPPPGAPHGPPIQQPAGVAQWDQHRYPP-QQGPPPPPQQQQQPQ-QQQQQPPY-QQVAGPPGQ 1595
                    .||||              ||. .:|..|..:..|:.| ..|:|.|| ...:.....
Zfish  1391 --------SHGPP--------------YPSMSRGDDPEARVSQESQWPGQRQSPYPSHSSSSSSS 1433

  Fly  1596 QPPQAPPQWAQMNPGQTAQSGIAPPGSPLRPPSGPGQQNRMPGMPAQQQQSQQQGGVPQPPPQQA 1660
            .||.|..|               ||.|...||:.|...:|                ||.|.|...
Zfish  1434 MPPMASRQ---------------PPSSYQSPPAMPNHISR----------------VPSPAPFPR 1467

  Fly  1661 SHGGVPSPGLPQVGPGGMVKPPYAMPPPPSQGVGQQVGQGPPGGMMSQKPPPMPGQAMQQQPLQQ 1725
            |.||..||....:                               |.|.|....||
Zfish  1468 SVGGSMSPTKAHM-------------------------------MASLKQMQKPG---------- 1491

  Fly  1726 QPPSHQHPHPHQHPQHQHPHQMPPNQTAPGGYGPPGMPGGGAQLVKKELIFPHDSVESTTPVLYR 1790
                             .|..||.:|:.       |:||.|...:.:|:.:|.||||:|.|.|..
Zfish  1492 -----------------GPVSMPSSQSG-------GLPGQGFSSIHREVNYPLDSVEATQPQLKP 1532

  Fly  1791 RKRLMKADVCPVDPWRIFMAMRSGLLTECTWALDVLNVLLFDDSTVQFFGISNLPGLLTLLLEHF 1855
            |:||...|:...:.||:.|:::||||.|.|||||.:|:||:||:||..||:|.|||.|.|::|.|
Zfish  1533 RRRLTSKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNTVSSFGLSQLPGFLELIVEFF 1597

  Fly  1856 QKNLAEMF---DERE--NEEQSALLAEDADDDADSGTVMCEKLRTSGRQPRC----VRSISSYNR 1911
            ::.|.|:|   :|.|  .|.|..||...::.             |..:||..    .:||:.:..
Zfish  1598 RRCLIEIFGILEEYEVGTEGQKTLLGSCSEP-------------TEKQQPSTPDFKSQSIAEHVE 1649

  Fly  1912 RR-----------------HYENMDRSGKDGAGNGSDSEDADEGIDLGQVRVQPNPEERSLLLSF 1959
            :|                 ..|..:.|.:|.|    |.|:.:.|.| ....|:|.|::.|
Zfish  1650 KRLDVEPEKPQPSSSAAALVMEKKEESAEDKA----DDEEKNTGKD-PCPPVEPRPKQAS----- 1704

  Fly  1960 TPNYTMVTRKGVPVRIQ--PAENDIFVDERQKAWDIDTNRLYEQLEPVGSDAWTYGFTEPDPLDG 2022
              .|..     :||:|:  .||.|. |::|.:                              |.|
Zfish  1705 --KYDR-----LPVKIEEKDAEEDC-VEDRSE------------------------------LLG 1731

  Fly  2023 IIDVFKSEIVNIPFARYIRSDKKGRKRTELASSSRKPEIKT--EENSTEEQTFNKKRRLVSGGSS 2085
            :...|||                |....:.........|:|  |.:..|||..          .:
Zfish  1732 LAGEFKS----------------GLLHWKAGGGDSTAHIQTYFERSWEEEQPL----------EN 1770

  Fly  2086 SSGAHAEGKKSKLTSEEFAQPNAEVKKE-PGTADSDCRPVDMDIEAPQQRLTNGVAPCSSTPAIF 2149
            ..|..|.||:   |.||..:...|:|:| ||.::.:......|:      |.:.....|...:..
Zfish  1771 QEGVQAIGKE---TVEEQPRGQEELKRELPGPSEENLTATVDDV------LKSNPGSISEGESQT 1826

  Fly  2150 DPRTTAKDEARVLQRRRDSSFEDECYTRDEASLHLVSESQDSLARRCIALSNIFRNLTFVPGNET 2214
            .|..|.::::.:      :..|||....|||.|.:....||.||:|||.:|||.|.|:|||||:.
Zfish  1827 FPFRTRENKSSI------TLLEDEPRCWDEAPLSVAESWQDELAKRCICVSNIIRGLSFVPGNDN 1885

  Fly  2215 VLAKSTRFLAVLGRLLLLNHEHLRRTPKTRNYDREEDTDFSDSCSSLQGEREWWWDYLITIRENM 2279
            .||:....:.:||:|:||:|||.:|......|.|||:...  :||    :.|||||.|..:|||.
Zfish  1886 ELARHPGLVLILGKLVLLHHEHPKRKRMPATYQREEERGL--ACS----KDEWWWDCLGALRENT 1944

  Fly  2280 LVAMANIAGHLELSRYDELIARPLIDGLLHWAVCPSAHGQDPFPSCGPNSVLSPQRLALEALCKL 2344
            ||.:|||:|.|:||.|.|.|..|::||||||.|||||..||||.:....|.|:||||.||.||||
Zfish  1945 LVTLANISGQLDLSVYPESICLPILDGLLHWMVCPSAEAQDPFCTANGFSSLTPQRLVLECLCKL 2009

  Fly  2345 CVTDANVDLVIATPPFSRLEKLCAVLTRHLCRNEDQVLREFSVNLLHYLAAADSAMARTVALQSP 2409
            .:.|:||||::|||||.|.|:|.|.|.||:...:.||.||.:|.:|..||..|...||.||||..
Zfish  2010 SIQDSNVDLLLATPPFGRQERLFATLVRHVGDRKSQVCREMAVAVLSNLAQGDPTAARAVALQKG 2074

  Fly  2410 CISYLVAFIEQAEQTALGVANQHGINYLRENPDSMGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQ 2474
            .:..|::|:|.:...|....:.|.:.::..:......|::|:.|||..||.:||..:||..|:..
Zfish  2075 SVGALISFLEDSVAMAQYQQSPHSLLHMGHSTQHEPPSINMMCRAAKALLAMAKVEENRPEFVLF 2139

  Fly  2475 EQRLLGLVMSHILDQQVALIISRVLYQVSR 2504
            |.|||.:.:|.:|:..||.|:..||:::.|
Zfish  2140 ESRLLDISLSSVLNSGVAAILCEVLFKLGR 2169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	42/90 (47%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854	119/259 (46%)
arid1b	XP_005160411.1	Med15	254..>717	CDD:255446	170/583 (29%)
		Med15	508..>940	CDD:255446	157/562 (28%)
		BRIGHT	959..1050	CDD:128777	42/90 (47%)
		DUF3518	1862..2116	CDD:288854	119/259 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590823
Domainoid	1	1.000	235	1.000	Domainoid score	I2295
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	613	1.000	Inparanoid score	I873
OMA	1	1.010	-	-		QHG46609
OrthoDB	1	1.010	-	-		D135670at33208
OrthoFinder	1	1.000	-	-		FOG0002548
OrthoInspector	1	1.000	-	-		otm26225
orthoMCL	1	0.900	-	-		OOG6_104640
Panther	1	1.100	-	-	O	PTHR12656
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2249
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.000