DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and arid1ab

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	XP_021323975.1	Gene:	arid1ab / 568161	ZFINID:	ZDB-GENE-030131-5725	Length:	2261	Species:	Danio rerio

Alignment Length:	2768	Identity:	776/2768 - (28%)
Similarity:	1053/2768 - (38%)	Gaps:	789/2768 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KIKSPQTQQQQQ----------------GGAPA-----PAATPPSAGAAPGAATPPT----SGPP 43
            ::|.|:.:.|.:                ||:|.     ..|...:|....||...|.    :|.|
Zfish    15 ELKKPEREPQDESVIGEKQQESKEPRADGGSPGQKELQDGADVGNAAGGGGAGGDPDMKNGNGNP 79

  Fly    44 T--PNNNSNNGSDPSIQQQQQNVAPHPYGA-PPPPGSGPGGPPGPDPAAVMHYHH--LHQQQQQH 103
            :  .||||.|.|..........:|||..|| ||||.|           ...||:.  .||
Zfish    80 SRVNNNNSQNDSGGPEGNSHPGMAPHHPGAFPPPPYS-----------YNQHYNRAPFHQ----- 128

  Fly   104 PPPPHMQQQQHHGGPAPPPPGGAPEHAPGVKEEYTHLPPPHPHP-----AYGRYHADPNMDPYRY 163
                       |||...|...|     |.|.:.|    ||:.|.     .:..|...||..||..
Zfish   129 -----------HGGQQSPGMAG-----PAVMDPY----PPNSHEHGYPNHFNNYSPFPNRTPYHQ 173

  Fly   164 GQPLPGGKPPQQQQPHPQQQPPQQPGPGGSPNRPP--------QQRYIPGQPPQGPTPTLNSLLQ 220
            ||......|...|.|....||.:||..||:   .|        .|||..|.|....|||||.||.
Zfish   174 GQGYGMNSPRNSQPPAAGGQPGKQPPTGGT---TPLATAASYNNQRYNMGNPQPTSTPTLNQLLT 235

  Fly   221 SSNPPPPPQHRYANTYDPQQAAASAAAAAAAQQQQAGG----------PPP--PGH-------GP 266
            |.:.....|:..|:.|..|:.||.......:..|..||          |||  ||:       .|
Zfish   236 SPSSTRSYQNYPASEYGGQEGAAKGPGDMGSSSQYGGGHPAWQQRSHHPPPMSPGNTGQANRTQP 300

  Fly   267 PPPQHQPSPYGGQQGGWAPPPRPYSPQLGPSQQYRTPPPTNTSRGQSPYPPAHGQNSGSYPSSPQ 331
            |.|..|.....||..|   ...|||.|.|       |||  :|:...|||   ||..|  |..||
Zfish   301 PGPMDQVGKIRGQHYG---AGNPYSQQQG-------PPP--SSQQGPPYP---GQGYG--PPGPQ 348

  Fly   332 QQQQQQQQQQQ------QAGQQPGGPVPGGPPPGTGQQPPQQNTPPTSQYSPYPQRYPTPPGLPA 390
            :.....|.:..      |.|||.|....|  |.|.||          :|...|.|:.|:|.|.|
Zfish   349 RYPMGMQGRTSGNLSGIQYGQQMGYGQHG--PGGYGQ----------NQAGYYGQQGPSPHGGP- 400

  Fly   391 GGSNHRTAYSTHQYPEPNRPWPGGSSPSPGSGHPL---PPASPHHVPPLQQQPPPPPHV-SAGGP 451
                .:::|       |.:|     |..|||..|.   |..:||.........|..||| :.|.|
Zfish   401 ----QQSSY-------PQQP-----STGPGSQPPYSQQPSGTPHGQSGTSYGQPQGPHVPNQGQP 449

  Fly   452 P----PSSSPGHAPSPSPQPSQASPSPHQELIGQNSNDSSSGGAHSGMGSGPP-----------G 501
            |    |.|..|.:|.|..|....|..|.|   ||..:.|..|..|...|||.|           |
Zfish   450 PYSQTPQSQSGQSPFPQSQGPTQSQGPSQ---GQQGSQSQPGYTHPPSGSGQPAQQQGPSQQQQG 511

  Fly   502 TPNPQQVMRPTPSPTGSSGSRSMSPAVAQNHPISRPASNQSSSGGPMQQPPVGAGGPPPMPPHPG 566
            .|..|......|.|:..:..:......:|..|:......|.....|.|:.|
Zfish   512 PPQSQTPSSAPPQPSQQTSGQGQPSPYSQTPPLQTQQQQQQQQQSPFQRFP-------------- 562

  Fly   567 MPGGPPQQQQSQQQQASNSASSASNSP------------QQTPPPAPPPNQGMNNMATPPPPPQG 619
                ||.|:.||...:|.|::.:||.|            |..|...|..:..::::      |.|
Zfish   563 ----PPPQELSQDSFSSQSSAPSSNQPIVSSKSGQDDTMQGRPSSLPDLSGSIDDL------PTG 617

  Fly   620 AAGGGYPMPPHMHGGYKMGGPGQSPGAQGYPPQQPQQYPPGNYP-------PRPQYPPGAYATGP 677
            ..|...|       |....|...|.|.|..|.|.|  :.|...|       |.|. |.|:.|:||
Zfish   618 TEGALSP-------GVSTSGVSSSQGEQSNPAQSP--FSPHTSPHLSGIRGPSPS-PVGSPASGP 672

  Fly   678 -----PPPPTSQAGAGGANSM---PSGAQAGG--YPGRGMPNHTGQYPPYQWVPP------SPQQ 726
                 |..|.:..|    |.|   ||..|:.|  :...|......:.|...:..|      ||:|
Zfish   673 ASRTGPLSPGTMPG----NQMPPRPSSVQSDGMLHSSMGQDRVYMRNPQMPYGSPQSGSTLSPRQ 733

  Fly   727 TVPGGAPGGAMVGNHVQG---------------KGTPPPPVVGGPPPPQGSGSPRPLNYLKQHLQ 776
            |  .|:...|.:|::.|.               :|.|.||..||.|.....|.|
Zfish   734 T--SGSQMHAGMGSYPQNNSMGNYGPQSGQYGPQGYPRPPGYGGMPNANYPGGP----------- 785

  Fly   777 HKGGYGGSPTPPQGPQGYGNGPTGMHPGMPMGPPHHMGP------PHGPTNMGPPTSTPPQSQML 835
               |.|||..|..| || |.||.|   ||   ||..|||      |:|| .|||.
Zfish   786 ---GMGGSMNPMAG-QG-GGGPYG---GM---PPGRMGPGQMGTRPYGP-GMGPN---------- 828

  Fly   836 QGGQPQGQGASGGPESGGPEHISQDNGISSSGPTGAAGMHAVTSVVTTGPDGTSMDEVSQQSTLS 900
            .||.|. |.|||.....|.....||        ..|||||       .||              |
Zfish   829 MGGMPP-QVASGMCPPPGMNRKPQD--------PAAAGMH-------HGP--------------S 863

  Fly   901 NASAASGEDPQCTTPKSRKNDPYSQSHLAPPSTS-----------PHPVVM---HPGGGPGEEYD 951
            |:.......|...........||     |||..|           |.|..|   ..|..|..|:.
Zfish   864 NSIHRPPGYPNMNQGMMGAGSPY-----APPMNSMQGMMNQAGQYPMPGNMSNNSAGMAPSPEFG 923

  Fly   952 MSSPPNWPRPAGSPQVFNH----VPVPQEPFRSTITTTKKSDSLCKLYEMDDNPDRRGWLDKLRA 1012
            |..       ....|..|:    .|..:...:|:.:|| .::.:.:|||:...|:|:.|:|:..|
Zfish   924 MDK-------LNQSQKLNNKVDGTPKTESKKKSSSSTT-TNEKITRLYELGPEPERKLWVDRYLA 980

  Fly  1013 FMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGASSSAAYTLRK 1077
            |.||:...::..|.:.::||||:|||:.|||.||..:|.|:|.|:::|..|.:|.|||||.:|:|
Zfish   981 FAEEKAMGMSNLPAVGRKPLDLFRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKK 1045

  Fly  1078 HYTKNLLTFECHFDRGDIDPLPIIQQVEAGSKKKTAKAASVPSP-GGGHLDA-GTTNSTGSSNSQ 1140
            .|.:.|..|||..:||: ||.|  .......||..|| ...||| |.|.|.. .|..||.||.::
Zfish  1046 QYIQCLYAFECKIERGE-DPPP--DFFNNDPKKNQAK-VQPPSPAGSGSLQGPQTPQSTSSSMAE 1106

  Fly  1141 --DSFPAPPGSAPNAAIDGYPGYPGGSPY-----PVASGPQPDYATAGQMQRPPSQNNPQTPHPG 1198
              |..|..|.|.|::.:   |..||....     |.|.|..|.:          |:.|..||:.|
Zfish  1107 GGDLKPPTPASTPHSQM---PPMPGARSSVNLQDPFADGGDPAF----------SRRNSVTPNSG 1158

  Fly  1199 AAAAVAAGDNISVSNPFE---DPIAAGGGPGSGTG-PGPGQGPGPGAASGGAGAVGAVGGGPQPH 1259
            ....:...|.:....|||   ||.  ||...:|.. ..|||||..|.             |.|
Zfish  1159 YQPGMGGPDMMGRMGPFEPNKDPF--GGMRKAGEQFMNPGQGPNSGM-------------GEQ-- 1206

  Fly  1260 PPPPHSPHTAAQQAAGQHQQQHPQHQHPGLPG----PPPPQQQQGQQGQQP---PPSVGGGPPPA 1317
                   :..|.|....:.|...:.|:|..||    |.......|..|.||   |.....|
Zfish  1207 -------YNRASQGPMGNMQMGQRQQYPYGPGYDRRPDSSMGPDGNMGPQPNMMPSGADAG---- 1260

  Fly  1318 PQQHGPGQVPPSPQQH---VRPAAGAPYPPGGSGYPTPVSRTPGSPYPS-QPGAYGQYGSSDQYN 1378
              .:.|.: ||..|:|   ....||...||.|             |||: |.|.|.|  ....|.
Zfish  1261 --MYSPNR-PPQQQRHDSYSNQYAGQGAPPSG-------------PYPNQQSGMYPQ--QQPNYT 1307

  Fly  1379 ATGPPGQPFGQGPGQYPPQNR---NMYP----PYGPEGE-APPTGANQYGPYGSRPYSQPPPGGP 1435
            ...|....:|      ||..|   :|||    ..||:.. ||.:.::.|..|.:.|.|:..|.||
Zfish  1308 QKRPVDGVYG------PPAKRHEGDMYPFSGQQQGPQAPGAPQSQSDMYNQYNTYPGSERRPPGP 1366

  Fly  1436 QPPTQTVAG-----GPPAGGAPGAPPSSAYPTGRPSQQDYYQPPPDQSPQPRRHPDFIKDSQPYP 1495
            |  :|...|     ||..||          |..:||..
Zfish  1367 Q--SQFPFGFGRDRGPNVGG----------PNSQPSMP--------------------------- 1392

  Fly  1496 GYNARPQIYGAWQSGTQQYRPQYPSSPAPQNWGGAPPRGAAPPPGAPHGPPIQQPAGVAQWDQHR 1560
                 ||:.|:..|||.   |..|..|....|   |.|.....|                    .
Zfish  1393 -----PQMMGSSMSGTM---PSVPDGPQGPMW---PGRNEMNYP--------------------N 1426

  Fly  1561 YPPQQGPPPPPQQQQ-----------QPQQQ-------------QQQPPYQQVA-GPPGQQPPQA 1600
            |..:||||..|.|.|           .|..|             |:||||..|| |||..:|.|
Zfish  1427 YHNRQGPPGVPSQSQVYHGMNRSEDMMPSDQRMNQEGPWPGHVNQRQPPYGPVASGPPMSRPLQ- 1490

  Fly  1601 PPQWAQMNPGQTAQSGIAPPGSPLRPPSGPGQQNRMPGMPAQQQQSQQQGGVPQPPPQQASHGGV 1665
                                      |:....||.:|           |...|.|.|:...:...
Zfish  1491 --------------------------PNYQSSQNHIP-----------QVSSPAPMPRPMENRTS 1518

  Fly  1666 PSPGLPQVGPGGMVKPPYAMPPPPSQGVGQQVGQGPPGGMMSQKP-PPMPGQAMQQQPLQQQPPS 1729
            |:            |.||..|                 ||..||. ||:|...:.|.|:|
Zfish  1519 PN------------KSPYMHP-----------------GMKIQKAGPPVPASHIAQPPVQ----- 1549

  Fly  1730 HQHPHPHQHPQHQHPHQMPPNQTAPGGYGPPGMPGGGAQLVKKELIFPHDSVESTTPVLYRRKRL 1794
                                         ||        ::::::.||..|:|::.|:|..|:||
Zfish  1550 -----------------------------PP--------MIRRDIAFPPGSIEASQPILKPRRRL 1577

  Fly  1795 MKADVCPVDPWRIFMAMRSGLLTECTWALDVLNVLLFDDSTVQFFGISNLPGLLTLLLEHFQKNL 1859
            ...|:...:.||:.|:::||||.|.|||||.:|:||:||:::..|.::.|||.|.|::|:|::.|
Zfish  1578 TMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSISNFNLNQLPGFLELVVEYFRRCL 1642

  Fly  1860 AEMF--------------------------DERENEEQSALLAEDADD--DADSGTVMCEKLRTS 1896
            .|:|                          .:.|..|...:..:|.||  |.::.||...:::..
Zfish  1643 IEIFGILKEYEVGDPGQRTLIDPEAIDPEMSDEEGPEAEQMEEDDEDDEEDLENNTVQTSQVQIK 1707

  Fly  1897 GRQPRCVRSISS--YNRRRHYENMDRSGKDGAGNGSDSEDADEGIDLGQVRVQPNPEERSLLLSF 1959
            ..:...:.|..|  .|.....|..|.|.||...:.:..:|....        |..|::.|..
Zfish  1708 QEKEESMESPKSNDKNELEDREGEDNSCKDHLRSSTPLQDTSAS--------QERPKQASKF--- 1761

  Fly  1960 TPNYTMVTRKGVPVRIQPAENDIFVDE-----RQKAWDIDTNRLYEQLEPVGSDAWTYGFTEPDP 2019
                     ..:|::|...::...:..     |::|:|            .|...|:.|  ..|.
Zfish  1762 ---------DKLPIKIMRKKDPFVIGHTSKLGRRQAFD------------SGLIHWSVG--GGDT 1803

  Fly  2020 LDGIIDVFKSEIVNIPFARYIRSDKKGRKRTELASSSRKPE---IKTEENSTEEQTFNKKRRLVS 2081
            .:.|...|:|::..:          |.|||..:....||..   ::|.....|:...|:..:.|.
Zfish  1804 TEHIQTHFESKMELL----------KHRKRVPVNVEPRKKVSQILETVTGEAEKVQTNEGPQQVQ 1858

  Fly  2082 GGSSSSGAHAEGKKSKLTSEEFAQPNAEV----KKEPGTADSDCRPVDMDIEAPQQRLTNGVAPC 2142
            ..:|......|| ||..||.......|.:    ....|:|..:....:.|.:..:.....|:
Zfish  1859 VLASKDQPSLEG-KSTTTSSTSTSITATIDDVLSARRGSATEEAVRGNQDSDKEKNTFLFGI--- 1919

  Fly  2143 SSTPAIFDPRTTAKDEARVLQRRRDSSFEDECYTRDEASLHLVSESQDSLARRCIALSNIFRNLT 2207
                          |.|:  |.|.....|||.:::||..|..:|:.||:||||||.:|||.|:|:
Zfish  1920 --------------DLAQ--QSRNIKILEDEPHSKDETPLCTLSDWQDALARRCICVSNIVRSLS 1968

  Fly  2208 FVPGNETVLAKSTRFLAVLGRLLLLNHEHLRRTPKTRNYDREEDTDFSDSCSSLQGER-EWWWDY 2271
            |:|||:..::|....|.:||||:||:|.|..|......|::||:.|...||     || |||||.
Zfish  1969 FIPGNDLEMSKHPGLLLLLGRLVLLHHWHPERKQAPVTYEKEEEEDEGVSC-----ERDEWWWDC 2028

  Fly  2272 LITIRENMLVAMANIAGHLELSRYDELIARPLIDGLLHWAVCPSAHGQDPFPSCGPNSVLSPQRL 2336
            |..:|||.||.:|||:|.|:||.|.|.|..||:||||||||||||...||||:.|.|..||||||
Zfish  2029 LEVLRENCLVTLANISGQLDLSIYPESICLPLLDGLLHWAVCPSAEAIDPFPTLGLNGTLSPQRL 2093

  Fly  2337 ALEALCKLCVTDANVDLVIATPPFSRLEKLCAVLTRHLCRNEDQVLREFSVNLLHYLAAADSAMA 2401
            .||.|.||.:.|.||||::|||||||||||...|.|.:...:..|.||.:|.||..||..|:..|
Zfish  2094 VLETLSKLSIQDNNVDLILATPPFSRLEKLYGSLVRMVGDRKVTVCREMAVVLLANLAQGDTVAA 2158

  Fly  2402 RTVALQSPCISYLVAFIEQAEQTALGVANQHGINYLRENPDSMGTSLDMLRRAAGTLLHLAKHPD 2466
            |.:|:|...:..|:.|:|.:........:|..:.:|:.:|.. .||:||:||||..|..|||..:
Zfish  2159 RAIAVQKGSVGNLLGFLEDSLAATQFQQSQGSLLHLQGSPFE-PTSVDMMRRAARALHALAKVEE 2222

  Fly  2467 NRSLFMQQEQRLLGLVMSHILDQQVALIISRVLYQVSR 2504
            |.|.|...|.|||.:.:|.:::..|:.:|..||:.:.:
Zfish  2223 NHSEFTLYESRLLDISVSPLMNSLVSHVICDVLFLIGQ 2260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	40/90 (44%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854	126/260 (48%)
arid1ab	XP_021323975.1	Glutenin_hmw	<127..473	CDD:281191	124/419 (30%)
		RRM	<352..468	CDD:330708	41/144 (28%)
		BRIGHT	969..1060	CDD:128777	40/90 (44%)
		Med15	1069..>1512	CDD:312941	153/616 (25%)
		BAF250_C	1952..2207	CDD:314843	126/260 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590822
Domainoid	1	1.000	235	1.000	Domainoid score	I2295
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	613	1.000	Inparanoid score	I873
OMA	1	1.010	-	-		QHG46609
OrthoDB	1	1.010	-	-		D135670at33208
OrthoFinder	1	1.000	-	-		FOG0002548
OrthoInspector	1	1.000	-	-		otm26225
orthoMCL	1	0.900	-	-		OOG6_104640
Panther	1	1.100	-	-	LDO	PTHR12656
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000