DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osa and Arid3c

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	NP_001017362.1	Gene:	Arid3c / 550619	MGIID:	3650624	Length:	409	Species:	Mus musculus

Alignment Length:	611	Identity:	137/611 - (22%)
Similarity:	191/611 - (31%)	Gaps:	268/611 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   818 GPTNMGPPTSTPPQSQMLQGGQ----PQGQ-GASGGPESGGPEHISQDNGISSSGPTGAAGMHAV 877
            ||  :.||....||..:| |.:    |:|. |..|..|..|.|        ...|.|..|
Mouse    17 GP--LAPPRLPLPQPPLL-GARTLQAPEGAIGVVGAEEEEGAE--------DEEGETPLA----- 65

  Fly   878 TSVVTTGPDGTSMDEVSQQSTLSNASAASGEDPQCTTPKSRKNDPYSQSHLAPPSTSPHPVVMHP 942
                        .:|.::||           .|....|    |.|.|||    |...||
Mouse    66 ------------EEETAEQS-----------HPGARCP----NSPSSQS----PGIQPH------ 93

  Fly   943 GGGPGEEYDMSSPPNWPRPAGSPQVFNHVPVPQEPFRSTITTTKKSDSLCKLYEMDDNPDRRGWL 1007
                          .|              ..:|.|:             :|||:|.:|.|:.:|
Mouse    94 --------------EW--------------TYEEQFK-------------QLYELDADPKRKEFL 117

  Fly  1008 DKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGAS-SSA 1071
            |.|.:||::|.||:...|.::||.||||.|:..|..:||.|||...|.|:::...|.:..: :||
Mouse   118 DDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSA 182

  Fly  1072 AYTLRKHYTKNLLTFECHFDRGDIDPLPIIQQVEAGSKKKTAKAASVPSPGGGHLDAGTTNSTGS 1136
            |:|||..|.|.|..:||.                       .:|.|.|    |.|.| ..:|...
Mouse   183 AFTLRTQYMKYLYPYECE-----------------------TRALSSP----GELQA-AIDSNRR 219

  Fly  1137 SNSQDSFPAPP-----GSAPNAAIDGYPGYPGGSPYPVAS-GPQPDYATAGQMQRPPSQNNPQTP 1195
            ...:.::.|.|     |..|.           |:|.|.:| ||.|   ||             ||
Mouse   220 EGRRQAYTAVPLFNLAGPTPR-----------GAPGPASSHGPAP---TA-------------TP 257

  Fly  1196 HPGAAAAVAAGDNISVSNPFEDPIAAGGGPGSGTGPGPGQGPGPGAASGGAGAVGAVGGGPQPHP 1260
            :                                 .|||.||...|..:.....:       .|.|
Mouse   258 N---------------------------------CPGPTQGSASGLPAHACAQL-------SPSP 282

  Fly  1261 --------PPPH--SPHTAAQQAAGQHQQQHPQHQHPGLPGPPPPQQQQGQQGQQPPPSVGGGPP 1315
                    |||.  .|...|.:|.  .::..|:.         ||:::....|....|.:|..|.
Mouse   283 VKKEESGIPPPRLALPMGLASEAT--REKLAPEE---------PPEKRAVLMGPVDSPRLGAPPS 336

  Fly  1316 PAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSG-----------------------YPTPVSRTP 1357
            ..|:    |:.|...::     ...|....|||                       .|.|.|..|
Mouse   337 FLPR----GKAPLREER-----LDGPLNLAGSGISSINVALEINGVVYTGILFARRQPVPASLGP 392

  Fly  1358 GSPYPSQPGAYGQYGSSDQYNATGPP 1383
            .:| |..|             :||||
Mouse   393 TNP-PPLP-------------STGPP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	38/91 (42%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854
Arid3c	NP_001017362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		29/120 (24%)
		BRIGHT	111..202	CDD:128777	38/113 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..274		19/100 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..333		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..409		11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.900