DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and let-526

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	NP_001368147.1	Gene:	let-526 / 3565337	WormBaseID:	WBGene00002717	Length:	1768	Species:	Caenorhabditis elegans

Alignment Length:	2380	Identity:	599/2380 - (25%)
Similarity:	842/2380 - (35%)	Gaps:	776/2380 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 PGTPNPQQVMRPTPSPTGSSGSRSMSPAVAQNHPISRPASNQSSSGGPMQQPPVGAGGPPPMPPH 564
            ||..|..........||.|:       ||...:|         |.|...||
Worm     2 PGDDNAVGTETNEDKPTTSN-------AVTAENP---------SRGDESQQ-------------- 36

  Fly   565 PGMPGGPPQQQQSQQQQ-----ASNSASSAS------NSPQQTP--PPAPPPNQGMNNMATPPPP 616
                    ||||.||||     |...|:|.:      ..|::..  ||||.        |:.|.|
Worm    37 --------QQQQPQQQQKRGEDADKYAASVAEVAHGGGGPKKDDQVPPAPD--------ASMPTP 85

  Fly   617 PQGAAGGGYPMPPHMHGGYKMGGPGQSPGAQGYPPQQPQQYPPGNYPPR-PQYPPGAYATGPPPP 680
            .|.......|                       |||||.::|...:||: ...||.::|     |
Worm    86 QQQQQQPNLP-----------------------PPQQPYEHPAQQHPPQHHSVPPNSFA-----P 122

  Fly   681 PTSQAGAGGANSMPSGAQAGGYPGRGMPNHTGQYPPYQWVPPSPQQTVPGGAPGGAMVGNHVQGK 745
            |                     ||:..|.|.|. ||.:|.||..:..:|.|.|.|.
Worm   123 P---------------------PGQHHPQHPGM-PPMEWRPPGAEYQMPPGYPAGY--------- 156

  Fly   746 GTPPPPVVGGPPPPQGSGSPRPLNYLKQHLQHKGGYGGSPTPPQGPQGYGNGPTGMHPGMPMGPP 810
                ||.  |.||....|.|.|            .||  ..||..|.||  .|..|.|.| |.|.
Worm   157 ----PPY--GMPPRHHPGYPHP------------AYG--YPPPGAPYGY--PPQMMRPPM-MAPG 198

  Fly   811 HHMGPPHGPTNMGPPT--STPPQSQMLQGGQPQGQGASGGPESGGPEHISQDNGISSSGPTGAAG 873
            ..:..|.|||    ||  :...|:|......|..:|.:|.|.:  |...||..      |:.:|.
Worm   199 DMVRMPPGPT----PTEWAAQQQAQAASRSVPPKEGPNGNPAT--PSSSSQPI------PSPSAS 251

  Fly   874 MHAVTSVVTTGPDGTSMDEVSQQSTLSNASAASGEDPQCTTPKSRKNDPYSQSHLAPPSTSPHPV 938
            ..|..| :...|.||.|..                            .|..|.|  ||...|..:
Worm   252 SIAEES-LDDKPSGTKMPA----------------------------QPPPQQH--PPPPQPQQI 285

  Fly   939 V--MHPGGGPGEEYDMSS------PPNWPRPAG----SPQVFNHVPVPQEPFRSTITTTKKSDSL 991
            :  |.|...|.::...||      .|:.|:.:|    ..::|..:..|       ||.
Worm   286 MSPMPPQAPPSQQATPSSSAASVAAPDTPKVSGKVLSKAELFEKLVGP-------ITL------- 336

  Fly   992 CKLYEMDDNP-----DRRGWLDKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEVT 1051
                   .||     :|||:.::|..|.|....|:|..|.:|||.:||:||||.|:.:|||.:||
Worm   337 -------HNPMKVMAERRGFFERLIEFCEHNGEPLTMVPQVSKQSIDLHRLYIGVRAKGGFQQVT 394

  Fly  1052 KSKTWKDIAGLLG--IGASSSAAYTLRKHYTKNLLTFEC-HFDRGDIDPLPIIQQVEAGSKKKTA 1113
            |.|.||::.....  :..||:|.|.|||||.::||..|| ...|...|.:....:::...|::
Worm   395 KDKYWKNLCTEANPDLAESSAAGYQLRKHYQRHLLMLECRETGRNPEDEVAFADKMKRQRKRE-- 457

  Fly  1114 KAASVPSPGGGHLDAGTTNSTGSSNSQDSF-----------PAPPGSAPNAAIDGYPGYPGGSP- 1166
                   |.||:..|....:......|.|.           |.|||:.|.   :|.||.|.|.|
Worm   458 -------PAGGNAAAAAAVAAAQQGDQKSQHGAPGGSGAPPPGPPGAYPG---NGAPGGPPGGPP 512

  Fly  1167 -YPVASGPQPDYATAGQMQRPPSQNNPQTPHPGAAAAVAAGDNISVSNPFEDPIAAGGGPGSGTG 1230
             :|...|..|:|       ....|:....||||              :|       |..|.....
Worm   513 QFPGHPGMDPNY-------HYYQQHGMMPPHPG--------------HP-------GYPPQHMNA 549

  Fly  1231 PGPGQGPGPGAASGGAGAVGAVGGGPQPHPPPPHSPHTAAQQAAGQHQQQ---HPQ----HQHPG 1288
            ..|||.||.....||.       |||.|.|....:|.....|...:||:|   |.|    |.|..
Worm   550 FSPGQYPGHQRPPGGP-------GGPPPGPQAMRAPMPQHMQEMDEHQRQWYAHQQAAAAHHHAQ 607

  Fly  1289 LPGPPPPQQQQGQQGQQPPPSVGGGPPPAPQQHGPGQVPPSPQQHVRPAAGAPYPPGGSGYPTPV 1353
            .......|..|.||...|.||.    .||||.....|..|:...:.:||.    |...:..|||.
Worm   608 QQAAAQAQAAQAQQASTPAPST----TPAPQAASSSQAAPTSGANTQPAT----PSASNQPPTPA 664

  Fly  1354 SRTPGSPYPSQPGAYGQYGSSDQYNATGPPGQPFGQGPGQYPPQNRNMYPPYGPEGEAPPTGANQ 1418
            |.:..:....:|.:..  |.| |..:..|     ..|||.....:.:..|......:|..|.:::
Worm   665 SASASTTLHVEPASVA--GGS-QAGSRAP-----SAGPGPSATPDSSTIPSASAAADAQTTTSSE 721

  Fly  1419 YGPYGSRPYSQPPPGGPQPPTQTVAGGPPAGGAPGAPPSSAYPTGRPSQQDYYQPP--PDQSPQP 1481
            ....| .|.|..|...|.|.|..            .||:|..|   |..|   |||  |...|.|
Worm   722 TSTPG-EPTSSTPSDTPAPSTSV------------PPPTSVQP---PQPQ---QPPQGPPGPPGP 767

  Fly  1482 RRHPDFIKDSQPYPGYNARPQIYGAWQSGTQQYRPQYPSSPAPQNWGGAPPRGAAPPPGAPHGPP 1546
            ::||.      |||||                  |.|....|.:     ||.|.|||||||:|
Worm   768 QQHPG------PYPGY------------------PGYGPPGAMR-----PPAGFAPPPGAPYG-- 801

  Fly  1547 IQQPAGVAQWDQHRYPPQQGPPPP----------PQ-------QQQQPQQQQQQPPYQQVAGPPG 1594
                          |||  |.|||          ||       |||:..||||....||...|.|
Worm   802 --------------YPP--GAPPPAGFHPSHPQHPQHAQYLAWQQQRYHQQQQHQQQQQQGAPGG 850

  Fly  1595 QQPPQAPPQWAQMNPGQTAQSGIAPPGSPLRPPSGPGQQNRMPGMPAQQQQSQQQGGVPQPPPQQ 1659
            .:||...|            .|..|||.|         ||||                |.|||.|
Worm   851 PRPPYPYP------------GGPVPPGPP---------QNRM----------------PPPPPAQ 878

  Fly  1660 ASHGGVPSPGLPQVGPGGMVKPPYAMPPPPSQGVGQQVGQGP-PGGMMSQKPPPMPGQAMQQQP- 1722
                |.|||. ...|..|. :|.|..|.|||:      ...| |..:.|..|...|..:.|..|
Worm   879 ----GAPSPS-GAAGSNGK-QPRYGTPAPPSR------ASAPTPQPLSSTMPVVAPSTSTQPTPT 931

  Fly  1723 --------LQQQPPSHQHPHPHQHPQH---QHPHQMPP---NQTAPGGYGPPGMPGGGAQLVKKE 1773
                    |....|:|.......|..|   |..||.||   ..||.           ....||:.
Worm   932 TGSYLANTLATPGPAHAPSSSMSHAHHVISQQQHQYPPGCIEATAT-----------SQNQVKRR 985

  Fly  1774 LIFPHDSVESTTPVLYRRKRLMKADVCPVDPWRIFMAMRSGLLTECTWALDVLNVLLFDDS---- 1834
            .::..:.:.:|                   |.|:.|::||||..|..||::.|||||:||:
Worm   986 KVYARELINAT-------------------PRRLIMSLRSGLDAEAIWAINALNVLLYDDTNPHP 1031

  Fly  1835 TVQFFGISNLPGLLTLLLEHFQKNLAEMFDERENEEQSALLAEDADDDADSGTVMCEKLRTSGRQ 1899
            |:|     .:|||:.:::||....|:.|:.           ||....:.....:|.|...|
Worm  1032 TLQ-----QMPGLVNVIVEHLYATLSIMYP-----------AEFQLTEPGKPIIMDESKET---- 1076

  Fly  1900 PRCVRSISSYNRRRHYENMDRSGKDGAGNGSDSEDADEGIDLGQVRVQPNPEERSLLLSFTPNYT 1964
                           .|.|.::.|||            ||.....::...|.:.|   ..|..:|
Worm  1077 ---------------VEKMMKAEKDG------------GIKSIIEKMPVVPRKGS---DKTATFT 1111

  Fly  1965 MVTRKGVPVRIQ-----------------PAENDIFVDER-QKAWDIDTNR------LYEQLEPV 2005
            |::|.|:.|..:                 ...:|..||.. ..|:..|.|.      |.|::...
Worm  1112 MMSRNGLQVHFRDESIPTALRKRFSRESGEKNSDAMVDHSISSAYVEDRNSVGLGGGLAERIATR 1176

  Fly  2006 GSDAWTYGFTEPDPLDGIIDVFKSEIVNIPFARYIRSDKKGRKRTELASSSRKPEIKTEENSTEE 2070
            ..|...:..|.|.|:               |::|:                  .:::||...|.:
Worm  1177 LRDKLLHEKTRPRPV---------------FSKYL------------------DDLETESTETID 1208

  Fly  2071 QTFNKKRRLVSGGSSSSGAHAEGKKSKLTSEEFAQPNAEVKKEPGTADSDCRPVDMDIEAPQQR- 2134
                                                ..|||||            ::.|..:::
Worm  1209 ------------------------------------TVEVKKE------------IEDEVAEEKK 1225

  Fly  2135 ---LTNGVAP-----CSSTPAIFDPRTTAKDEARVLQRRRDSSFEDECYTRDEASLHLVSESQDS 2191
               |..|..|     |.....:..||.||                          |...|::.:.
Worm  1226 DVLLMRGARPDELSDCKHEVELAWPRPTA--------------------------LSPKSQAMEE 1264

  Fly  2192 LARRCIALSNIFRNLTFVPGNETVLAKSTRFLAVLGRLLLLN---H-------------EHLRRT 2240
            ||.|.:|||||.|..:||.|::.::|::...|.::||||.||   |             |.|:..
Worm  1265 LAHRALALSNILRGFSFVAGSDVLMARNEALLFIIGRLLKLNVKEHKISSKRPGIVMSAEELKTA 1329

  Fly  2241 PKTRNYD--REEDTDFSDSCSSLQGEREWWWDYLITIRENMLVAMANIAGHLELSRYDELIARPL 2303
            ||..:.|  |.::....|...:...:..   :....:|::..|.:.:::..|.|....:.||.|:
Worm  1330 PKQLSADEKRAKEKSVLDEVDATTAQMV---ETANQLRDDAFVMLTHMSVSLNLVDLPDAIAYPI 1391

  Fly  2304 IDGLLHWAVCPSAHGQDPFPSCGPNSVLSPQRLALEALCKLCVTDANVDLVIATPPFSRLEKLCA 2368
            .||||.|:|.......|....|    .:||:..:||.:||:.|.:.|||:.::|..:||:|:...
Worm  1392 YDGLLRWSVSRVPEATDSSIPC----PVSPRDYSLEIMCKMVVIERNVDMFLSTGSWSRVEQFVH 1452

  Fly  2369 VLTRHLCRNEDQVLREFSVNLLHYLAAADSAMARTVALQSPCISYLVAFIEQAEQTALGVANQHG 2433
            :|||.|..||:...|||::.:|:.|..|..|:....|:::..|::|:.||:.|:|....|...||
Worm  1453 ILTRLLTMNEETHYREFAIVILNALCIASEAVCYICAMETSAIAHLILFIDSADQNMHQVMQAHG 1517

  Fly  2434 INYLRENPDSMGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMSHILDQQVALIISRV 2498
            :..||:||:.||||:.||||||..|..|.|.|....::|:.:.|||...||.::|.:||.:|:..
Worm  1518 MAALRDNPELMGTSVGMLRRAASMLRLLVKVPKAYKIYMKHQTRLLQFTMSQLMDSRVAGMIADT 1582

  Fly  2499 LYQVSRGTGPIHSVEFRLLQQRQQQQLRPGPAGKQAASAGGSATVKAETASTETSSTEAKPAPAA 2563
            ||::.         ||    .::..:..|.|. |...|.|...:...:..||.|:|..|.|
Worm  1583 LYEIQ---------EF----VKEFGEDVPEPL-KITYSEGYQPSQTDDKESTSTNSDAAAP---- 1629

  Fly  2564 TTAVVNDENSNSSQQLPPAATFNDVSNSSTNSNSCGTASSNQTNNSTTNSSHSSSAISSQSAITV 2628
                  .:.|.||...|.             ..|..|.|.|...|.|.....||..:||::|..|
Worm  1630 ------PQKSTSSSPKPV-------------EESAATTSVNVHGNGTLECETSSRPLSSEAAAAV 1675

  Fly  2629 AAP-----------------SAAATGAGSATAAAIASDQQQVSKVAAAAAAAAALSNASAAAAAA 2676
            ..|                 ....:..|..|.|...|.::         :|||.:...|.:...|
Worm  1676 ITPYENHHKNEEEEDLKKEIDEGESCDGYDTEAIRLSQKR---------SAAALIDEQSRSPPPA 1731

  Fly  2677 AAAAAASVGPPTSSSVSAGAAVAQPAAPPPTNAGTTTAVA 2716
            ..|..::....:.||||....:...:   ..:...|||||
Worm  1732 KRAHLSNGFDKSKSSVSTNGTLGDAS---QNDGALTTAVA 1768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	42/98 (43%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854	88/277 (32%)
let-526	NP_001368147.1	ARID_ARID1A-like	344..438	CDD:350629	41/93 (44%)
		PHA03247	<625..916	CDD:223021	118/421 (28%)
		PRK12323	<626..>741	CDD:237057	32/131 (24%)
		BAF250_C	1264..1535	CDD:403301	88/277 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159558
Domainoid	1	1.000	186	1.000	Domainoid score	I2002
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I774
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46609
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002548
OrthoInspector	1	1.000	-	-		oto18935
orthoMCL	1	0.900	-	-		OOG6_104640
Panther	1	1.100	-	-	LDO	PTHR12656
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4068
SonicParanoid	1	1.000	-	-		X2249
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.020