DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osa and Arid1b

DIOPT Version :9

Sequence 1:	NP_001163639.1	Gene:	osa / 42130	FlyBaseID:	FBgn0261885	Length:	2716	Species:	Drosophila melanogaster
Sequence 2:	XP_006523284.2	Gene:	Arid1b / 239985	MGIID:	1926129	Length:	2306	Species:	Mus musculus

Alignment Length:	2856	Identity:	755/2856 - (26%)
Similarity:	1045/2856 - (36%)	Gaps:	940/2856 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GGAPAPAATPPSAGAAPGAATP-PTSG------------PPTP-----------------NNNSN 50
            |..|||.|.....||....|.| |..|            |..|                 :|::.
Mouse    23 GPRPAPGARDLETGARGAVAAPGPILGGGDGGLNNVHHHPLHPRHDLNMAHSASAAAAASSNSAQ 87

  Fly    51 NGSDPSIQQQQQNVAPHPYGAPPPPGSGPGGPPGPDPAAVMHYHHLHQQQQQHPPPPHMQQQQHH 115
            :|...:..::..:.|.....|.....|...||.......::..|.|....:....|||.|...||
Mouse    88 SGRSEAALKEGGSAAALSSSAAVAASSSSAGPGSTMETGLLPNHKLKAVGEAPAAPPHQQHHHHH 152

  Fly   116 GGPAPPPPGGAPEHAPGVKEEYTHLPPPHPHPAYGRYHADPNMDPYRYGQPLPGGKPPQQQQPHP 180
                      |..|              |.|.|:..:|...:   :...|.|     .|.|||
Mouse   153 ----------AHHH--------------HHHHAHHLHHLHHH---HALQQQL-----NQFQQP-- 183

  Fly   181 QQQPPQQPGPGGSPNRPPQQRYIPGQPPQGPTPTLNSLLQSSNPPPPPQHRYANTYDPQQAAASA 245
              ||||           |||:    |||               |||..||..||.        |.
Mouse   184 --QPPQ-----------PQQQ----QPP---------------PPPQQQHPTANN--------SL 208

  Fly   246 AAAAAAQQQQAGGPPPPGHGPPPPQHQPSPYGGQQGGWAPPPRPYSPQLGPSQQYRTPPPTNTSR 310
            ..|       .||.|.||.....|||     ||.:...|      ..|..|..|    |..:...
Mouse   209 GGA-------GGGAPQPGPDMEQPQH-----GGAKDSVA------GNQADPQGQ----PLLSKPG 251

  Fly   311 GQSPYPPAHGQNSGSYPSSPQQQQQQQQQQQQQAGQQPGG------------------PVPGGP- 356
            .:...||..|:.:||....|....|||....    ..|||                  |..|||
Mouse   252 DEDDAPPKMGEPAGSRYEHPGLGAQQQPAPV----AVPGGGGGPAAVSEFNNYYGSAAPASGGPG 312

  Fly   357 --------------PPGTG-------------QQPPQQNTP---PTSQYSPYPQRYPTPPGLPAG 391
                          .||.|             ...|.||:.   |.|||:.||..  :.||...|
Mouse   313 GRAGPCFDQHGGQQSPGMGMMHSASAAAGAPSSMDPLQNSHEGYPNSQYNHYPGY--SRPGAGGG 375

  Fly   392 GSNHRTAYSTHQYPEPNRPWPGGSSPSPGSGHPLPPASPHHVPPLQQQPPPPPHVSAGGPPPSSS 456
            |..                  ||.....|.|.....|.                 .|||...:::
Mouse   376 GGG------------------GGGGGGSGGGGGGGGAG-----------------GAGGAAAAAA 405

  Fly   457 PGHAPSPSPQPSQASPSPHQELIGQNSNDSSSGGAHSGMGSGPPG-----TPNPQ---QVMRPTP 513
            ...|.:.:...:.|:.:            ::.||...|.||...|     :|..|   .:|.|
Mouse   406 GAGAVAAAAAAAAAAAA------------AAGGGGGGGYGSSSSGYGVLSSPRQQGGGMMMGP-- 456

  Fly   514 SPTGSSGSRSMSPAVA--------------QN-HPI-SRPASNQ-SSSGGPMQQ------PPVGA 555
               |..|:.|:|.|.|              || ||. :.|..|| .:|..||.:      |...:
Mouse   457 ---GGGGAASLSKAAAGAAAAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPDYSS 518

  Fly   556 GGPPPMPPHPGMPGGPPQQQQSQ---------QQQASN------------SASSASNSPQQTPPP 599
            ...||          ||.|.|||         ||.|:.            :||.|..:.||...|
Mouse   519 SSAPP----------PPSQPQSQAAAGAAAGGQQAAAGMGLGKDLGAQYAAASPAWAAAQQRSHP 573

  Fly   600 A-----PPPNQG----------------MNNMATPP--PPPQGA--AGGGYPMPPHMHGGYKMGG 639
            |     |.|..|                :..|.|.|  .|.|.:  .||.|..|....  |.:|.
Mouse   574 AMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGTHPHSQPQQSSPYPGGSYGPPGAQR--YPLGM 636

  Fly   640 PGQSPGAQG---YPPQQ-PQQY---------------------PPGNYPPRPQY--PPGA----- 672
            .|::|||.|   ||.|| |.||                     .|.:.||:.||  |..|
Mouse   637 QGRAPGALGGLQYPQQQMPPQYGQQAVSGYCQQGQQPYYNQQPQPSHLPPQAQYLQPAAAQSQQR 701

  Fly   673 -----------YATGPPPP------------------PTSQAG-AGGANSMPSGAQA-------- 699
                       |.|...||                  |:|... :|..:.:|:|.:|
Mouse   702 YQPQQDMSQEGYGTRSQPPLAPGKSNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSA 766

  Fly   700 -GGYPGRGMPNHTGQYP--PYQWVPPSPQ-QTVPGG---APGGAMVGNHVQGKGTPPPPVVGG-- 755
             |....:|..::..|.|  |:    .||. .::|||   :|.|:.||::....|...|..:.|
Mouse   767 SGSTSSQGDQSNPAQSPFSPH----ASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQ 827

  Fly   756 -PPPPQG-----------SGSPRPLNYLKQHLQHKGGYGGSPTPPQGPQGYGNGPTGMHPGMPM- 807
             ||.|.|           |.||.|        |.:|.|..:||....|....:||   .|||.:
Mouse   828 MPPQPPGSQSESSSHPALSQSPMP--------QERGNYSRTPTYSGVPSASYSGP---GPGMGIN 881

  Fly   808 --GPPHHMGP--PHGPTNMGPPTSTPPQSQMLQGGQ----PQGQGAS--GGPESGGP-------- 854
              ...|..||  |.|...:|...|...|::...|..    |...|.|  |||..|.|
Mouse   882 ANNQMHGQGPAQPCGAMPLGRMPSAGMQNRPFPGTMSSVTPSSPGMSQQGGPGMGPPMPTVNRKA 946

  Fly   855 ----EHISQDNGISSSGPTGA-AGMHAVTSVVTTGPDGTSMDE-----------VSQQSTLSNAS 903
                ..:.|....|:....|: .||:....|.::.|...||:.           .|...|:.|:|
Mouse   947 QEAAAAVMQAAANSAQSRQGSFPGMNQSGLVASSSPYSQSMNNNSSLMSTQAQPYSMTPTMVNSS 1011

  Fly   904 AAS---------------------GEDPQCTTPKSRKNDPYSQSHLAPPSTS---PHPVVMHPGG 944
            .||                     |::...:.|:|:..|.|....::.|.|.   |.|..|.|..
Mouse  1012 TASMGLADMMSPSESKLSVPLKADGKEEGVSQPESKSKDSYGSQGISQPPTPGNLPVPSPMSPSS 1076

  Fly   945 GP-----GEEYDMSSPPNWPRPAGSPQVFNHVPVPQEPFRSTITTTKKSDSLCKLYEMDDNPDRR 1004
            ..     |:|.|..|.|.||:            .|..|..|:.:||  .:.:.|:||:.:.|:|:
Mouse  1077 ASISSFHGDESDSISSPGWPK------------TPSSPKSSSSSTT--GEKITKVYELGNEPERK 1127

  Fly  1005 GWLDKLRAFMEERRTPITACPTISKQPLDLYRLYIYVKERGGFVEVTKSKTWKDIAGLLGIGASS 1069
            .|:|:...|||||.:|:::.|.:.|:||||:|||:.|||.||..:|.|:|.|:::|..|.:|.||
Mouse  1128 LWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSS 1192

  Fly  1070 SAAYTLRKHYTKNLLTFECHFDRGDIDPLPIIQQVEAGSKKKTAKAASVPSP-GGGHLDAGTTNS 1133
            |||.:|:|.|.:.|..|||..:||: :|.|  :....|..||..| ...||| ..|.|....|..
Mouse  1193 SAASSLKKQYIQYLFAFECKTERGE-EPPP--EVFSTGDSKKQPK-LQPPSPANSGSLQGPQTPQ 1253

  Fly  1134 TGSSNSQDSFPAPPGSAPNAAIDGYPGYPGGSPYPVASGPQPDYATAGQMQRPPSQNNPQTPHPG 1198
            :..|||....|.          |..|..|..:|:             |||  .|.|:
Mouse  1254 STGSNSMAEVPG----------DLKPPTPASTPH-------------GQM--TPMQS-------- 1285

  Fly  1199 AAAAVAAGDNISVSNPFEDPIAAGGGPGSGTGPGPGQGPGPGAASGGAGAVGAVGGGPQPHPPPP 1263
                 .....:||.:||.|                        .|..|        .|:.:...|
Mouse  1286 -----GRSSTVSVHDPFSD------------------------VSDSA--------YPKRNSMTP 1313

  Fly  1264 HSPHTAAQQAAGQHQQQHPQHQHPGLPGPPPPQQQQGQQGQQPPPSVGGGPPPAPQQHGPGQVPP 1328
            ::|:                                 |||...|..:             |::|.
Mouse  1314 NAPY---------------------------------QQGMGMPDMM-------------GRMPY 1332

  Fly  1329 SPQQHVRPAAGAPYPPGGSGYPTPVSRTPGSPYPSQPGAYGQYGSSDQYNATGPPGQPFGQGPGQ 1393
            .|.:.  |.:|....||.|           .|:.:| |.....|..|.||.: |.|.....|.||
Mouse  1333 EPNKD--PFSGMRKVPGSS-----------EPFMTQ-GQVPNSGMQDMYNQS-PSGAMSNLGMGQ 1382

  Fly  1394 YPPQNRNMYP----------PYGPE--GEAPPTGANQYGPYGSRPYSQPPPGGPQPPTQTVAGGP 1446
                 |..:|          .||.:  |:.||||             |||.||.||
Mouse  1383 -----RQQFPYGTSYDRRHEAYGQQYPGQGPPTG-------------QPPYGGHQP--------- 1420

  Fly  1447 PAGGAPGAPPSSAYPTGRPSQQDYYQPPPD--QSPQPRRHPDFIKD----SQPYPGYNARPQIYG 1505
                       ..||     ||..|:...|  ..|..:||...:.:    ||....||.    ||
Mouse  1421 -----------GLYP-----QQPNYKRHMDGMYGPPAKRHEGDMYNMQYGSQQQEMYNQ----YG 1465

  Fly  1506 AWQSGTQQYRPQYPSSPAPQNWGGAPPRGAAPPPG--APHGPPIQQPAGVAQWDQHRYPPQQGPP 1568
            ...||..: ||.....|.|.|      |.....||  .|||.|.|...|         |.|....
Mouse  1466 GSYSGPDR-RPIQGQYPYPYN------RERMQGPGQMQPHGIPPQMMGG---------PMQSSSS 1514

  Fly  1569 PPPQQQQQPQQQQQQPPYQQVAGPPGQQPPQAPPQWAQMNPGQTAQSGIAPPGSPLRPPSGPGQQ 1633
            ..|||.....:.....|||...||.|  |.||||.                          || .
Mouse  1515 EGPQQNMWATRNDMPYPYQSRQGPGG--PAQAPPY--------------------------PG-M 1550

  Fly  1634 NRMPGMPAQQQ----QSQQQGGVPQPPPQQASHGGVPSPGLPQVGPGGMVKPPYAMPPPPSQGVG 1694
            ||...|...:|    :||....|.|..|..:|...:               .|...||..|.
Mouse  1551 NRTDDMMVPEQRINHESQWPSHVSQRQPYMSSSASM---------------QPITRPPQSSY--- 1597

  Fly  1695 QQVGQGPPG--GMMSQKPPPMPGQAMQQQPLQQQPPSHQHPH-PHQHPQHQHPHQMPPNQTAPGG 1756
                |.||.  ..:|:.|.|    |..|:.|:.:....:.|. |....|...| .:|.:|..
Mouse  1598 ----QTPPSLPNHISRAPSP----ASFQRSLESRMSPSKSPFLPTMKMQKVMP-TVPTSQVT--- 1650

  Fly  1757 YGPPGMPGGGAQLVKKELIFPHDSVESTTPVLYRRKRLMKADVCPVDPWRIFMAMRSGLLTECTW 1821
             |||..|    ..:::|:.||..|||::.|:|.:|:::...|:...:.||:.|:::||||.|.||
Mouse  1651 -GPPPQP----PPIRREITFPPGSVEASQPILKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTW 1710

  Fly  1822 ALDVLNVLLFDDSTVQFFGISNLPGLLTLLLEHFQKNLAEMF----------------DERENEE 1870
            |||.:|:||:|||||..|.:|.|.|.|.||:|:|:|.|.::|                |.|..::
Mouse  1711 ALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHRSGKK 1775

  Fly  1871 QSALLAED----ADDDADSGTVMCEKLRTSGRQPRCVRSISSYNRRRHYENMDRSGKDGAGNGSD 1931
            ..:...||    .||||:                 |   :.........|..|....:..|..|.
Mouse  1776 DDSQSLEDDSGKEDDDAE-----------------C---LVEEEEEEEEEEEDSEKIESEGKSSP 1820

  Fly  1932 SEDA-DEGIDLGQVRVQPNPEERSLLLSFTPNYTMVTRKGVPVRIQPAENDIFVDERQ----KAW 1991
            :..| |..:|         |:|       ||.......| :|::| ..:|.:||.:|.    :..
Mouse  1821 ALAAPDASVD---------PKE-------TPKQASKFDK-LPIKI-VKKNKLFVVDRSDKLGRVQ 1867

  Fly  1992 DIDTNRLYEQLEPVGSDAWTYGFTEPDPLDGIIDVFKSEIVNIPFARYIRSDKKGRKRTELASSS 2056
            :..:..|:.||.  |.|.                   :|.:...|...:....:.|....|:|:.
Mouse  1868 EFSSGLLHWQLG--GGDT-------------------TEHIQTHFESKMEIPPRRRPPPPLSSTG 1911

  Fly  2057 RKPEIKTEENSTEEQTFNKKRRLVSGGSSSSGAHAEGKKSKLTSEEFAQPNAEVKKEPGTADSDC 2121
            :|.|::.:.:|.|:.                      :||.:     |..:..:...||....|.
Mouse  1912 KKKELEGKGDSEEQP----------------------EKSII-----ATIDDVLSARPGALPEDT 1949

  Fly  2122 RPVDMDIEAPQQ---RLTNGVAPCSSTPAIFDPRTTAKDEARVLQRRRDSSFEDECYTRDEASLH 2183
            .|      .||.   :...|:....|                   .|.....|||..:|||..|.
Mouse  1950 NP------GPQTDSGKFPFGIQQAKS-------------------HRNIRLLEDEPRSRDETPLC 1989

  Fly  2184 LVSESQDSLARRCIALSNIFRNLTFVPGNETVLAKSTRFLAVLGRLLLLNHEHLRRTPKTRNYDR 2248
            .::..|||||:|||.:|||.|:|:|||||:..::|....:.:||:|:||:|||..|....:.|::
Mouse  1990 TIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEK 2054

  Fly  2249 EEDTDFSDSCSSLQGEREWWWDYLITIRENMLVAMANIAGHLELSRYDELIARPLIDGLLHWAVC 2313
            |||.|...:||    :.|||||.|..:|:|.||.:|||:|.|:||.|.|.|..|::||||||.||
Mouse  2055 EEDEDKGVACS----KDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVC 2115

  Fly  2314 PSAHGQDPFPSCGPNSVLSPQRLALEALCKLCVTDANVDLVIATPPFSRLEKLCAVLTRHLCRNE 2378
            |||..|||||:.|||||||||||.||.||||.:.|.||||::|||||||.||..|.|.|::...:
Mouse  2116 PSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRK 2180

  Fly  2379 DQVLREFSVNLLHYLAAADSAMARTVALQSPCISYLVAFIEQAEQTALGVANQHGINYLRENPDS 2443
            :.|.||.|:.||..||..|:..||.:|:|...|..|::|:|.....|....:||.:.:: :.|..
Mouse  2181 NPVCREMSMALLSNLAQGDTLAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHM-QPPPL 2244

  Fly  2444 MGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMSHILDQQVALIISRVLYQVSR 2504
            ...|:||:.|||..||.:|:..:|||.|:..|.|||.:.:|.:|:..||.:|..||:|:.:
Mouse  2245 EPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICDVLFQIGQ 2305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osa	NP_001163639.1	BRIGHT	1001..1092	CDD:128777	43/90 (48%)
osa	NP_001163639.1	DUF3518	2191..2451	CDD:288854	127/259 (49%)
Arid1b	XP_006523284.2	PHA03307	568..>923	CDD:223039	92/371 (25%)
		ARID_ARID1B	1124..1216	CDD:350641	43/91 (47%)
		Med15	1237..>1617	CDD:312941	139/628 (22%)
		BAF250_C	1997..2252	CDD:403301	127/259 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846079
Domainoid	1	1.000	253	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG2510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	602	1.000	Inparanoid score	I937
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46609
OrthoDB	1	1.010	-	-		D135670at33208
OrthoFinder	1	1.000	-	-		FOG0002548
OrthoInspector	1	1.000	-	-		otm43665
orthoMCL	1	0.900	-	-		OOG6_104640
Panther	1	1.100	-	-	O	PTHR12656
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4068
SonicParanoid	1	1.000	-	-		X2249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930