DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alt and Rrbp1

DIOPT Version :9

Sequence 1:	NP_001262679.1	Gene:	alt / 42127	FlyBaseID:	FBgn0038535	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_077243.2	Gene:	Rrbp1 / 81910	MGIID:	1932395	Length:	1464	Species:	Mus musculus

Alignment Length:	966	Identity:	221/966 - (22%)
Similarity:	401/966 - (41%)	Gaps:	202/966 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GGAATKKPKKKE----------------LKREKKQRQREQQRDVNNEPEPEEAEDYSDGQSEGQG 99
            |.||.|:.||.|                .|.|..|.|.::.....|:.:..|.......:.||..
Mouse   422 GEAAQKQDKKIEGAQNQGKKPEGTSNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQ 486

  Fly   100 SVAGEEPGLSKQHVEFE------PDAEVLTDQRR----PSSVAEKENQPSGAGKKGKKDKRNGAN 154
            :...:..|...|..:.|      ...|...:|.:    |.:.|:|.......||||:     ||.
Mouse   487 NQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGPQNQAKKGEGAQNQGKKGE-----GAQ 546

  Fly   155 NKTAGILVNKNETVAVKPAANAEETPTLNNFETKIPKDVVELKKQE--QKERKEDNNNKQQSQKK 217
            |:      .|....|......||...:             :.||.|  |.:.|:.:.|..|.:|.
Mouse   547 NQ------GKKGEGAQNQGKKAEGVQS-------------QSKKGEGTQNQGKKGDGNPNQGKKG 592

  Fly   218 IAGGNVSKKEKVVAVE-TEAPVVTKQILK---------------QQQQQQNGSPK--TQHNQANN 264
            ....|.::|...||.: |:...|:.|:.|               .|.::::|||.  .:.:.|.|
Mouse   593 EGASNQNRKTDTVANQGTKQEGVSNQVKKSEGSPNQGKKAEGAPNQGKKKDGSPSQAKKVDAAAN 657

  Fly   265 KTKQQQQNKKQNQKETLTGKDLAHALDKLADHQNQT----------------IGVNALMNVFSRA 313
            :.|:.:....|.||.::.....|...|..|..::.:                :....|::.....
Mouse   658 QGKKSEMAPAQGQKASMVQSQEAPKQDAPAKKKSGSRKKGEPGPPDCDGPLFLPYKTLVSTVGSM 722

  Fly   314 ELNRSEIQILIDYLLNKQ---QDMPASHSEWSDDICQKLKRQLEEKEKLLAEEQEASIGIQAKLR 375
            ..:..|.|.||:.|..|.   ||.....::..|.:. .|||||||||||||.|||.:...::|||
Mouse   723 VFSEGEAQRLIEILSEKTGVIQDTWHKATQKGDPVA-ILKRQLEEKEKLLATEQEDAAVAKSKLR 786

  Fly   376 ELRQEVNTERAQMHARNQAYIDKLQGKEQELAALN-----------QELSSLNDKL-TLERQ--- 425
            ||.:|:.:|:|:..|.......:|..:|||:||:.           :|:..|..|: ||:.|
Mouse   787 ELNKEMASEKAKAAAGEAKVKKQLVAREQEIAAVQARMQASYRDHVKEVQQLQGKIRTLQEQLEN 851

  Fly   426 ----QLTTLRRE------------KQANSQDLVQLQHLQQDLAHKEKCLAEMTAFVNAETQQKNE 474
                ||..|::|            .|..|:...:|..|:|:|:.           ||.|..:|:|
Mouse   852 GPNTQLARLQQENSILRDALNQATSQVESKQNTELAKLRQELSK-----------VNKELVEKSE 905

  Fly   475 VIQQQAQQLQALE-----LQREELEARQNNSIFELEQRKQLEAENADLKQELSAVQQTQSELQRV 534
            ..:|:.||.:|||     .:::.|:.:.::...|...:|:||    ::.:||...|.:.:.| |.
Mouse   906 ASRQEEQQRKALEAKAATFEKQVLQLQASHKESEEALQKRLE----EVTRELCRAQTSHANL-RA 965

  Fly   535 HAAELQELRQNLSVLEARNVALSQQLTQAANSAVQATAAQSEQAQVQTEALAQKQQELSALRSQV 599
            .|.:.||.:|.::.|.:: :..|:...::....:.:...|.::|:.:...|.::.:.:.|| .:.
Mouse   966 DAEKAQEQQQRVAELHSK-LQSSEVEVKSKCEELSSLHGQLKEARAENSQLTERIRSIEAL-LEA 1028

  Fly   600 GSLTDAHAQQQKQANALQSQLQEAQQRAEQLQAKEQHLQQELQEQREKNNDVRMKNWKLIEALQN 664
            |...|..| ...:||..|::|:|.:.:...|:.:...|::.:::|:.||||:|.||||.:|||..
Mouse  1029 GQAQDTQA-SHAEANQQQTRLKELESQVSCLEKETSELKEAMEQQKGKNNDLREKNWKAMEALAL 1092

  Fly   665 AEALTAKTKTNSAQSVGQQHKELQLQQ----QKAVAANGGGSASSAKSEQQRIRDLYQR------ 719
            ||....:...:..|:..:..|:|.|.:    :..:|...|.|.|:.::..:.:::..::
Mouse  1093 AERACEEKLRSLTQAKEESEKQLHLAEAQTKETLLALLPGLSISAHQNYAEWLQEFKEKGSELLK 1157

  Fly   720 ----LYP--DAV-----KAQSGNALQASFDQW---------LEQVLATHVKQQQDKLRQKLDAEK 764
                |.|  |.|     ..::.|:|||..||:         :.:.|...|::::...:.|:.|.:
Mouse  1158 KPPTLEPSMDIVLKLREAEETQNSLQAECDQYRTILAETEGMLKDLQKSVEEEERVWKAKVGAAE 1222

  Fly   765 SEKQSSS---SH--------KSTQSSNSSSSNHNSTHNNISSNNSSSNSQSSSAAEQQELHKQNL 818
            .|...|.   .|        |....|:.....|.|     ..........::::||.|...|:..
Mouse  1223 EELHKSRVTVKHLEDIVEKLKGELESSDQVREHTS-----HLEAELEKHMAAASAECQNYAKEVA 1282

  Fly   819 QLRECNDKLTQLVTKTTNTLMDLEERAREQDEHWRGIVEQKEQLILTLQQHASNGE 874
            .||       ||:.::.:.|.:.:..|::|.:. ..:|.|:   :..::.|..:|:
Mouse  1283 GLR-------QLLLESQSQLDEAKSEAQKQSDE-LALVRQQ---LSDMRSHVEDGD 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alt	NP_001262679.1	SMC_prok_B	<398..694	CDD:274008	83/335 (25%)
Rrbp1	NP_077243.2	Rib_recp_KP_reg	33..171	CDD:282899
		Tropomyosin	833..1081	CDD:278679	63/266 (24%)
		SPEC	877..1071	CDD:295325	48/212 (23%)
		PRK02224	968..>1448	CDD:179385	79/379 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4381
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.990