DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alt and RRBP1

DIOPT Version :9

Sequence 1:	NP_001262679.1	Gene:	alt / 42127	FlyBaseID:	FBgn0038535	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_001352542.1	Gene:	RRBP1 / 6238	HGNCID:	10448	Length:	1410	Species:	Homo sapiens

Alignment Length:	880	Identity:	207/880 - (23%)
Similarity:	352/880 - (40%)	Gaps:	191/880 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KRALSA-NLYKAAGGAATKKPKKKELKREKKQRQREQQRDVNNEPEPEEAEDYSDGQSEGQGSVA 102
            |:|..| |..|.|.||..:..|.:..:.:.|:.:..|.:....|....:.:.....|::|:.:..
Human   420 KKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEG 484

  Fly   103 GEEPGLSKQHVEFEPDAEVLTDQRRPSSVAEKENQP-SGAGKKGKKDKRNGANNKTAGILVNKNE 166
            .:..|         ..||...:|.:.:..|:.:.|. .||..:|||.:  ||..|.|....|:.:
Human   485 AQNQG---------KKAEGAQNQGKKAEGAQNQGQKGEGAQNQGKKTE--GAQGKKAERSPNQGK 538

  Fly   167 TVAVKPAANAEETPTLNNFETKIPKDVVELKKQE--QKERKEDNNNKQQSQKKIAGGNVSKKEKV 229
            .....| ...::..::.|..||:.....:.||.|  ..|.|:...:..|.:|..|..|..||.:.
Human   539 KGEGAP-IQGKKADSVANQGTKVEGITNQGKKAEGSPSEGKKAEGSPNQGKKADAAANQGKKTES 602

  Fly   230 VAVETEAPVVTKQILKQQQQQQNGSPKTQHNQANNKTKQQQQNKKQNQKETLTGKDLAHALDKLA 294
            .:|:.....|.:            ||:....:|..|.|...:.|.:.......|.
Human   603 ASVQGRNTDVAQ------------SPEAPKQEAPAKKKSGSKKKGEPGPPDADGP---------- 645

  Fly   295 DHQNQTIGVNALMNVFSRAELNRSEIQILIDYLLNKQ---QDMPASHSEWSDDICQKLKRQLEEK 356
                ..:....|::.......|..|.|.||:.|..|.   ||.....::..|.:. .||||||||
Human   646 ----LYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVA-ILKRQLEEK 705

  Fly   357 EKLLAEEQEASIGIQAKLRELRQEVNTERAQMHARNQAYIDKLQGKEQELAALN----------- 410
            |||||.|||.:...::|||||.:|:..|:|:..|.......:|..:|||:.|:.
Human   706 EKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHV 770

  Fly   411 QELSSLNDKL-TLERQ-------QLTTLRRE------------KQANSQDLVQLQHLQQDLAHKE 455
            :|:..|..|: ||:.|       ||..|::|            .|..|:...:|..|:|:|:.
Human   771 KEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSK-- 833

  Fly   456 KCLAEMTAFVNAETQQKNEVIQQQAQQLQALELQREELEARQNNSIFELEQRKQLEAENA----- 515
                     |:.|..:|:|.::|..||.:|||.:....|    ..:.:| |....|:|.|
Human   834 ---------VSKELVEKSEAVRQDEQQRKALEAKAAAFE----KQVLQL-QASHRESEEALQKRL 884

  Fly   516 -DLKQELSAVQQTQSELQRVHAAELQELRQNLSVLEARNVALSQQLTQAANSAVQATAAQSEQAQ 579
             ::.:||...|.:.:.| |..|.:.||.:|.::.|.:: :..|:...::....:.....|.::|:
Human   885 DEVSRELCHTQSSHASL-RADAEKAQEQQQQMAELHSK-LQSSEAEVRSKCEELSGLHGQLQEAR 947

  Fly   580 VQTEALAQKQQELSALRSQVGSLTDAHAQQQKQANALQSQ--LQEAQQRAEQLQAKEQHLQQELQ 642
            .:...|.::.:.:.|| .:.|...||...|..||.|.|.|  |:|.:.:...|:.:...|::.::
Human   948 AENSQLTERIRSIEAL-LEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVE 1011

  Fly   643 EQREKNNDVRMKNWKLIEALQNAEALTAKTKTNSAQSVGQQHKELQLQQQKAVAANGGGSASSAK 707
            :|:.||||:|.||||.:|||..||               |..||..|            |.:.||
Human  1012 QQKVKNNDLREKNWKAMEALATAE---------------QACKEKLL------------SLTQAK 1049

  Fly   708 SEQQRIRDLYQRLYPDAVKAQSGNAL-----------QASFDQWLEQVLATHVKQQQDKLRQKLD 761
            .|.::...|        ::||:..||           |.::.:||:.:
Human  1050 EESEKQLCL--------IEAQTMEALLALLPELSVLAQQNYTEWLQDL----------------- 1089

  Fly   762 AEKSEKQSSSSHKSTQSSNSSSSNHNSTHNNISSNNSSSNSQSSSAAEQQELHKQNLQLRECNDK 826
              |.:..:...|....:..||                   ..:|...|.:|  .|:....|| |:
Human  1090 --KEKGPTLLKHPPAPAEPSS-------------------DLASKLREAEE--TQSTLQAEC-DQ 1130

  Fly   827 LTQLVTKTTNTLMDLEERAREQDEHWRGIVEQKEQ 861
            ...::.:|...|.||::...|:::.||..|...|:
Human  1131 YRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEE 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alt	NP_001262679.1	SMC_prok_B	<398..694	CDD:274008	85/334 (25%)
RRBP1	NP_001352542.1	Rib_recp_KP_reg	33..165	CDD:309995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..648		54/265 (20%)
		41 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]-[GTAS]-[ATIS]-[PQTAS]	197..604		45/195 (23%)
		Neuromodulin_N	<290..1020	CDD:331332	160/657 (24%)
		SMC_N	698..1395	CDD:330553	142/563 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..925		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1093..1122		6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1287
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1330..1362
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1377..1410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159254
Domainoid	1	1.000	153	1.000	Domainoid score	I4297
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940