DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alt and Rrbp1

DIOPT Version :9

Sequence 1:	NP_001262679.1	Gene:	alt / 42127	FlyBaseID:	FBgn0038535	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	XP_230637.6	Gene:	Rrbp1 / 311483	RGDID:	1306536	Length:	1453	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	223/961 - (23%)
Similarity:	399/961 - (41%)	Gaps:	205/961 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EKRALSANLYKAAGGAATKKPKKKELKREKKQRQREQQRDVNNE--------PE--PEEAEDYSD 92
            :|...:.|..|...|...:..|.:.|:.:.|:.:..|::|...|        ||  |.:.:....
  Rat   370 KKGEANQNQAKKGEGGQNQTKKGEGLQNQGKKGEATQKQDKKIEGAQNQGKKPEGTPNQGKKGEG 434

  Fly    93 GQSEGQGSVAGEEPGLSKQHVEFE-PDAEVLTDQRRPSSVAEKENQP-SGAGKKGKK-------- 147
            .|::|:.....:..|...:..:.: ...|...:|.:....|:.:.:. .||..:|||
  Rat   435 AQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGAQNQG 499

  Fly   148 DKRNGANNKTAGILVNKNETVAVKPAAN----AEETP-------TLNNFETKIPKDVVELKKQE- 200
            .|..||.|:......:.::.:.|:...|    ||.||       ...|...|......:.||.|
  Rat   500 KKGEGAQNQGKKGEGSPSQNIKVEGMQNQGRKAEGTPAQGKKMEAAQNQGKKAEGVQSQGKKGEG 564

  Fly   201 -QKERKEDNNNKQQSQKKIAGGNVSKKEKVVAVE-TEAPVVTKQILK-----QQQQQQNGSPKTQ 258
             |.:.|:.:.|..|.:|.....|.::|...||.: |:...|:.|:.|     .|.::..|:|
  Rat   565 SQNQGKKGDGNPNQGKKGEGAPNQNRKTDTVANQGTKTEGVSNQVKKSEGSPNQGKKAEGAP--- 626

  Fly   259 HNQANNKTKQQQQNKK------QNQKETLT---GKDLAHALDKLADHQN---------------- 298
             ||.........|.||      |.:|..:|   ||:.:....:.|..|.
  Rat   627 -NQGKKVEGSPNQAKKVDAAAGQGKKSEMTPAQGKNASMVQSQEAPKQEAPAKKKSKKKGEPGPP 690

  Fly   299 --------------QTIGVNALMNVFSRAELNRSEIQILIDYLLNKQ---QDMPASHSEWSDDIC 346
                          .|:|    ..|||..|..|     ||:.|..|.   ||.....::..|.:.
  Rat   691 DCDSPLFLPYKTLVSTVG----SMVFSEGEAQR-----LIEILSEKTGVIQDTWHKATQKGDPVA 746

  Fly   347 QKLKRQLEEKEKLLAEEQEASIGIQAKLRELRQEVNTERAQMHARNQAYIDKLQGKEQELAALN- 410
             .|||||||||||||.|||.:...::|||||.:|:.:|:|:..|.......:|..:|||:||:.
  Rat   747 -VLKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMASEKAKAAAGEAKVKKQLVAREQEIAAVQA 810

  Fly   411 ----------QELSSLNDKL-TLERQ-------QLTTLRRE------------KQANSQDLVQLQ 445
                      :|:..|..|: ||:.|       ||..|::|            .|..|:...:|.
  Rat   811 RMQASYQDHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNTELA 875

  Fly   446 HLQQDLAHKEKCLAEMTAFVNAETQQKNEVIQQQAQQLQALE-----LQREELEARQNNSIFELE 505
            .|:|:|:.           ||.|..:|:|..:|:.||.:|||     .:::.|:.:.::...|..
  Rat   876 KLRQELSK-----------VNKELVEKSEASRQEEQQRKALEAKAATFEKQILQLQASHKESEEA 929

  Fly   506 QRKQLEAENADLKQELSAVQQTQSELQRVHAAELQELRQNL----SVLEARNVALSQQLTQAANS 566
            .:|:||    ::.:||...|.:.:.| |..|.:.||.:|.:    |.|::..|.:..:..:.::.
  Rat   930 LQKRLE----EVTRELCRAQTSHANL-RADAEKAQEQQQRVAELHSKLQSSEVEVKSKCEELSDL 989

  Fly   567 AVQATAAQSEQAQVQTEALAQKQQELSALRSQVGSLTDAHAQQQKQANALQSQLQEAQQRAEQLQ 631
            ..|...|::|.:|: ||.:...:..|.|.::|....:.|.|.||      |::|:|.:.:...|:
  Rat   990 HGQLKEARAENSQL-TERIRSIEALLEAGQAQDSQASRAEADQQ------QTRLKELESQVSCLE 1047

  Fly   632 AKEQHLQQELQEQREKNNDVRMKNWKLIEALQNAEALTAKTKTNSAQSVGQQHKELQLQQQKAVA 696
            .:...|::.:::|:.||||:|.||||.:|||..||....:...:..|:..:..|:|.|.:.:.
  Rat  1048 KETSELKEAMEQQKGKNNDLREKNWKAMEALALAERACEEKLRSLTQAKEESEKQLHLAEAQT-- 1110

  Fly   697 ANGGGSASSAKSEQQRIRDLYQRLYPD-AVKAQSGNALQASFDQWLEQVLATHVKQQQDKLRQK- 759
                             :::...|.|: ::.|..      ::..||::     ||::..:|.:|
  Rat  1111 -----------------KEVLLALLPELSIPAHQ------NYADWLQE-----VKEKGSELLKKP 1147

  Fly   760 -LDAEKSEKQSSSSHKSTQSSNSSSSNHNSTHNNISSNNSSSNSQSSSAAEQQELHKQNLQLREC 823
             :..|.|....|...::.::.||..:..:.....::...........|..|::.:.|..:...|
  Rat  1148 PVSVEPSLDIVSKLREAEETQNSLQAECDQYRTILAETEGMLKDLQKSVEEEERVWKAKVGAAE- 1211

  Fly   824 NDKLTQLVTKTTNTLMDLEERAREQDEHWRGIVEQKEQLILTLQQHASNGE 874
                 :.:.|:..|:..||:..    |..||.:|..:|    :::|.|:.|
  Rat  1212 -----EELQKSRFTVKHLEDLV----EKLRGELESSDQ----VREHTSHLE 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alt	NP_001262679.1	SMC_prok_B	<398..694	CDD:274008	87/335 (26%)
Rrbp1	XP_230637.6	Rib_recp_KP_reg	33..171	CDD:282899
		Tropomyosin	821..1069	CDD:278679	67/270 (25%)
		PRK02224	956..>1436	CDD:179385	73/345 (21%)
		Rootletin	959..>1073	CDD:291694	32/120 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353273
Domainoid	1	1.000	151	1.000	Domainoid score	I4257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4279
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18939
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.990